1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. EGF Superfamily Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. EGFR/ErbB family

The epidermal growth factor receptor (EGFR/ErbB) family consists of four closely-related receptor tyrosine kinases: ErbB-1 (HER1 or EGFR), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4), all of which are crucial not only for the determination of several epithelial, glial, muscle, and neuronal lineages, but they are also key players in pathological processes, such as malignant transformation. These transmembrane receptors are composed of an extracellular ligand-binding domain and a cytoplasmic region with enzymatic activity. The ligands bind to the extracellular domain of ErbB receptors, inducing formation of homo- and heterodimers, followed by autophosphorylation of the receptors and transphosphorylation of multiple downstream targets. The phosphorylated signaling proteins stimulate the activation of many signaling pathways, including the Ras-Raf-Mek-ERK, PI3K-Akt-Tor, PLC-γ1, signal transducer and activator of transcription (STAT), and Src pathways. The EGF family binds ErbB receptors, and on the basis of their receptor specificity, they are divided into three groups. 1) EGF, transforming growth factor (TGF)-α, amphiregulin (AR) and epigen (EPG), which bind specifically to EGFR. 2) beta-cellulin (BTC), heparin-binding EGF (HB-EGF) and epiregulin (EPR), which exhibit dual specificity, binding both EGFR and ErbB4. 3) the neuregulins (NRGs), forms two subgroups, depending on whether they bind ErbB3 and ErbB4 (NRG-1 and NRG-2) or only ErbB4 (NRG-3 and NRG-4).

Cat. No. Product Name / Synonyms Species Source
  • HY-P72374
    HER2/CD340 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    Proto-oncogene Neu; Tyrosine kinase-type cell surface receptor ERBB2; MLN19; NGL; TKR1

    Human HEK293
    The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.
  • HY-P72987
    EGFR Protein, Human (sf9, His-GST)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    Human Sf9 insect cells
    The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (sf9, His-GST) is the recombinant human-derived EGFR protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EGFR Protein, Human (sf9, His-GST) is 543 a.a., with molecular weight of ~89.1 kDa.
  • HY-P73035
    HER4 Protein, Human (HEK293, His-Fc)

    Receptor tyrosine-protein kinase erbB-4; 4ICD; E4ICD; s80HER4; ERBB4; HER4

    Human HEK293
    HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, His-Fc) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-hFc, C-10*His labeled tag.
  • HY-P73094
    HER2/CD340 Protein, Human (HEK293)

    Receptor tyrosine-protein kinase erbB-2; MLN 19; CD340; ERBB2; HER2; NEU; NGL

    Human HEK293
    The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (HEK293) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293 , with tag free.
  • HY-P7340
    EGFR Protein, Human (621a.a, CHO, His)

    rHuEGFR, His; ERBB; ERBB1; HER1

    Human CHO
    EGFR Protein, Human (CHO, His) is a transmembrane protein with His tag. EGFR Protein exerts tyrosine kinase activity upon ligand induced activation.
  • HY-P73517
    EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    Human HEK293
    The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) is 621 a.a., with molecular weight of ~99.5 kDa.
  • HY-P74177
    EGFR Protein, Human (621a.a, HEK293, Fc)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    Human HEK293
    EGFR Protein, a receptor tyrosine kinase, binds various ligands like EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, initiating signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation, and recruitment of adapter proteins like GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC, and STATs. EGFR can also trigger NF-kappa-B signaling, phosphorylate proteins like RGS16, and interact with MUC1, influencing G protein-coupled receptor signaling. Moreover, it enhances cell migration through interactions with CCDC88A, promoting EGFR signaling and triggering cell migration. Additionally, EGFR impacts learning, memory, and pain signaling. EGFR Protein, Human (621a.a, HEK293, Fc) is the recombinant human-derived EGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of EGFR Protein, Human (621a.a, HEK293, Fc) is 621 a.a., with molecular weight of 110-160 kDa.
  • HY-P78118
    EGFR Protein, Human (Biotinylated, HEK293, His-Avi)

    ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2

    Human HEK293
    The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of EGFR Protein, Human (Biotinylated, HEK293, His-Avi) is 621 a.a., with molecular weight of 80-110 kDa.
  • HY-P78138
    HER2/CD340 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD340; EGFR2; ErbB2; HER2; HER-2; herstatin; MLN 19; MLN19; Neu Oncogene; NEUHER-2/neu; NGL; p185erbB2; TKR1; ERBB2; HER-2/neu; NEU; ENV; ENVW; ERVWE1; HERV-7q; HERV-W-ENV; HERV7Q; HERVW; HERVWENV

    Human HEK293
    The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
  • HY-P78680
    HER2/CD340 Protein, Human (S310Y, HEK293, His)

    ERBB2; CD340; HER-2/neu; HER2; MLN19; NEU; NGL; TKR1

    Human HEK293
    The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. HER2/CD340 Protein, Human (S310Y, HEK293, His) is the recombinant human-derived HER2/CD340 protein, expressed by HEK293 , with C-10*His labeled tag and S310Y, , , , mutation.
  • HY-P78882
    Her2/CD340 Protein, Human (Biotinylated, HEK293, His)

    ERBB2; CD340; HER-2; neu; HER2; MLN19; NEU; NGL; TKR1

    Human HEK293
    The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics. Upon activation, it triggers the MEMO1-RHOA-DIAPH1 pathway, inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization. Her2/CD340 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Her2/CD340 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P70613
    EGFR Protein, Human (621a.a, HEK293, His)

    Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1

    Human HEK293
    The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of EGFR Protein, Human (621a.a, HEK293, His) is 621 a.a., with molecular weight of 90-120 kDa.
  • HY-P70322
    HER3 Protein, Human (HEK293, Fc)

    rHuReceptor tyrosine-protein kinase erbB-3/HER3, Fc; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3

    Human HEK293
    HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, Fc) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P70323
    HER3 Protein, Human (312a.a, HEK293, Fc)

    rHuReceptor tyrosine-protein kinase erbB-3/HER3-312AA, Fc; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3

    Human HEK293
    HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (312a.a, HEK293, Fc) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HER3 Protein, Human (312a.a, HEK293, Fc) is 311 a.a., with molecular weight of ~69 kDa.
  • HY-P70608
    EGFR Protein, Human (HEK293, Fc)

    Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR; ERBB; ERBB1; HER1

    Human HEK293
    The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (HEK293, Fc) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFR Protein, Human (HEK293, Fc) is 354 a.a., with molecular weight of 90-120 kDa.
  • HY-P72625
    HER3 Protein, Human (HEK293, His)

    Receptor tyrosine-protein kinase erbB-3; ERBB3; HER3

    Human HEK293
    HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P72988
    EGFR Protein, Mouse (HEK293, Fc)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    Mouse HEK293
    The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EGFR Protein, Mouse (HEK293, Fc) is 623 a.a., with molecular weight of ~142.57 kDa.
  • HY-P72989
    EGFR Protein, Mouse (HEK293, His)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    Mouse HEK293
    The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-His labeled tag. The total length of EGFR Protein, Mouse (HEK293, His) is 647 a.a., with molecular weight of ~100 kDa.
  • HY-P72990
    EGFR Protein, Rat (HEK293, His)

    Epidermal growth factor receptor; EGFR; ERBB; ERBB1; HER1

    Rat HEK293
    EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family.EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways.EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity.EGFR Protein, Rat (HEK293, His) is the recombinant rat-derived EGFR protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P73037
    HER4 Protein, Rat (HEK293, His)

    Receptor tyrosine-protein kinase erbB-4; 4ICD; E4ICD; s80HER4; ERBB4; HER4

    Rat HEK293
    HER4 Protein, crucial in central nervous system development, influences neural crest cell migration and axon guidance. Additionally, it participates in mammary gland differentiation, inducing milk proteins and contributing to lactation. HER4 Protein, Rat (HEK293, His) is the recombinant rat-derived HER4 protein, expressed by HEK293 , with C-His labeled tag.
Cat. No. Product Name Effect Purity