1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. EGF Superfamily Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. EGFR/ErbB family
  5. ErbB4/HER4

The receptor tyrosine-protein kinase ErbB4 (HER4) is a member of the epidermal growth factor receptor (EGFR) family, which also includes EGFR (ErbB1), ErbB2 (HER2/neu), and ErbB3 (HER3). The EGFR family members regulate cellular proliferation, differentiation, and programmed cell death in a growth factor-dependent manner. Similar to other RTKs, ligand interaction with ErbB4 promotes receptor dimerization, kinase activation, and initiation of phosphorylation-dependent signaling cascades, such as the mitogen-activated protein kinase (MAPK) and PI3-K/Akt cascades. ErbB4 is a fully functional RTK capable of signaling, both as a homo- as well as a heterodimer. It can be activated by at least seven members of EGF-related peptide growth factors: the neuregulins (NRG-1, NRG-2, NRG-3, and NRG-4), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC) and epiregulin (ER). In addition, unlike the other ERBB members, ErbB4 has been demonstrated undergo regulated intramembrane proteolysis (RIP), resulting in generation of a soluble intracellular domain (ICD). The released ErbB4 ICD is able to translocate to the nucleus and regulate transcription. ErbB4 and its ligands may have important roles in normal cardiovascular and neural development, differentiation of the mammary gland, and in pathological conditions, such as heart diseases and cancer.

Cat. No. Product Name / Synonyms Species Source
  • HY-P73035
    HER4 Protein, Human (HEK293, His-Fc)

    Receptor tyrosine-protein kinase erbB-4; 4ICD; E4ICD; s80HER4; ERBB4; HER4

    Human HEK293
    HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, His-Fc) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-hFc, C-10*His labeled tag. The total length of HER4 Protein, Human (HEK293, His-Fc) is 626 a.a., with molecular weight of 125-135 kDa.
  • HY-P73037
    HER4 Protein, Rat (HEK293, His)

    Receptor tyrosine-protein kinase erbB-4; 4ICD; E4ICD; s80HER4; ERBB4; HER4

    Rat HEK293
    HER4 Protein, crucial in central nervous system development, influences neural crest cell migration and axon guidance. Additionally, it participates in mammary gland differentiation, inducing milk proteins and contributing to lactation. HER4 Protein, Rat (HEK293, His) is the recombinant rat-derived HER4 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P70841
    HER4 Protein, Human (HEK293, His)

    Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4; ERBB4; HER4

    Human HEK293
    HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, His) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HER4 Protein, Human (HEK293, His) is 624 a.a., with molecular weight of 94-107 kDa.
  • HY-P700733
    HER4 Protein, Human (Biotinylated, HEK293, His-Avi)

    p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19

    Human HEK293
    HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of HER4 Protein, Human (Biotinylated, HEK293, His-Avi) is 626 a.a., with molecular weight of 75-110 kDa.
  • HY-P78454
    HER4 Protein, Human (HEK293, His-Avi)

    p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19

    Human HEK293
    HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, His-Avi) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of HER4 Protein, Human (HEK293, His-Avi) is 626 a.a., with molecular weight of 80-110 kDa.
  • HY-P701234
    HER4 Protein, Human (HEK293, hFc)

    p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19

    Human HEK293
    HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, hFc) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HER4 Protein, Human (HEK293, hFc) is 626 a.a., with molecular weight of 100-120 kDa.
  • HY-P73036
    HER4 Protein, Rat (HEK293, Fc)

    Receptor tyrosine-protein kinase erbB-4; 4ICD; E4ICD; s80HER4; ERBB4; HER4

    Rat HEK293
    HER4 Protein, crucial in central nervous system development, influences neural crest cell migration and axon guidance. Additionally, it participates in mammary gland differentiation, inducing milk proteins and contributing to lactation. HER4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER4 protein, expressed by HEK293 , with C-hFc labeled tag.
Cat. No. Product Name Effect Purity