1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  3. EGFR
  4. ErbB4/HER4 Inhibitors

ErbB4/HER4 Inhibitors

EGFR/ErbB1/HER1

ErbB2/HER2

ErbB3/HER3

ErbB4/HER4

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Sorry. There is currently no product that acts on isoform ErbB4/HER4 together.

Please try each isoform separately.

ErbB4/HER4 Specific Inhibitors
Product Name ErbB4/HER4 EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4 Selectivity Purity
Dacomitinib
ErbB4, IC50: 73.7 nM
EGFR, IC50: 6 nM
ErbB2, IC50: 45.7 nM
  Pan Inhibitor 99.92%
BMS-690514
HER4, IC50: 60 nM
EGFR, IC50: 5 nM
HER2, IC50: 20 nM
  Pan Inhibitor 99.89%
AZ-5104
ErbB4, IC50: 7 nM
EGFRL858R/T790M, IC50: 1 nM
EGFRL858R, IC50: 1 nM
EGFRL861Q, IC50: 6 nM
EGFR, IC50: 25 nM
    Pan Inhibitor 99.92%
TAS0728
HER4, IC50: 8.5 nM
EGFR, IC50: 65 nM
HER2, IC50: 13 nM
Human HER2, IC50: 36 nM
  Pan Inhibitor 99.53%
Varlitinib
HER4, IC50: 4 nM
HER1, IC50: 7 nM
HER2, IC50: 2 nM
  Pan Inhibitor >98.0%
PD158780
ErbB4, IC50: 52 nM (Cell Assay)
EGFR, IC50: 8 μM (Cell Assay)
ErbB2, IC50: 49 nM (Cell Assay)
ErbB3, IC50: 52 nM (Cell Assay)
Pan Inhibitor 98.04%
Allitinib tosylate
ErbB4, IC50: 0.8 nM
EGFR, IC50: 0.5 nM
EGFRL858R/T790M, IC50: 12 nM
ErbB2, IC50: 3 nM
  Pan Inhibitor 99.23%
Epertinib
HER4, IC50: 7.15 nM
EGFR, IC50: 1.48 nM
HER2, IC50: 2.49 nM
  Pan Inhibitor >98.0%
EGFR-IN-12
HER4, IC50: 7640 nM
EGFR (WT), IC50: 21 nM
EGFRL858R, IC50: 63 nM
EGFRL861Q, IC50: 4 nM
    Pan Inhibitor 99.49%
Epertinib hydrochloride
HER4, IC50: 2.49 nM
EGFR, IC50: 1.48 nM
HER2, IC50: 7.15 nM
  Pan Inhibitor 99.76%
CHMFL-EGFR-202
ErbB4, IC50: 3.2 nM
EGFRT790M, IC50: 5.3 nM
EGFR, IC50: 8.3 nM
ErbB2, IC50: 8.1 nM
  Pan Inhibitor
BGB-102
HER4, IC50: 40.3 nM
EGFR, IC50: 9.6 nM
HER2, IC50: 18 nM
  Pan Inhibitor
Allitinib
ErbB4, IC50: 0.8 nM
EGFR, IC50: 0.5 nM
EGFRL858R/T790M, IC50: 12 nM
ErbB2, IC50: 3 nM
  Pan Inhibitor