EGFR/ErbB-2/ErbB-4 inhibitor-3

Cat. No.: HY-103440 Purity: 98.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC₅₀s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

EGFR/ErbB-2/ErbB-4 inhibitor-3 Chemical Structure

CAS No. : 881001-19-0

Size	Price	Stock	Quantity
5 mg	USD 444	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 666	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1333	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2000	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Biological Activity
Purity & Documentation
References
Customer Review

Description

EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC₅₀s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively^[1]. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

ErbB2

1.1 nM (IC₅₀)

ErbB1

0.3 nM (IC₅₀)

ErbB4

0.5 nM (IC₅₀)

EGFR

2.5 nM (IC₅₀)

HER

24 nM (IC₅₀)

Molecular Weight

355.75

Formula

C₁₇H₁₁ClFN₅O

CAS No.

881001-19-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C#CC)NC1=CC(C(NC(C=C2)=CC(Cl)=C2F)=NC=N3)=C3C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (70.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8110 mL	14.0548 mL	28.1096 mL
5 mM	0.5622 mL	2.8110 mL	5.6219 mL
10 mM	0.2811 mL	1.4055 mL	2.8110 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.19%

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Data Sheet (271 KB) SDS (0 KB)

COA (248 KB) HNMR (154 KB) RP-HPLC (160 KB) LCMS (112 KB)

Handling Instructions (2659 KB)

References

[1]. Klutchko SR, et al. Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem. 2006 Feb 23;49(4):1475-85. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8110 mL	14.0548 mL	28.1096 mL	70.2741 mL
	5 mM	0.5622 mL	2.8110 mL	5.6219 mL	14.0548 mL
	10 mM	0.2811 mL	1.4055 mL	2.8110 mL	7.0274 mL
	15 mM	0.1874 mL	0.9370 mL	1.8740 mL	4.6849 mL
	20 mM	0.1405 mL	0.7027 mL	1.4055 mL	3.5137 mL
	25 mM	0.1124 mL	0.5622 mL	1.1244 mL	2.8110 mL
	30 mM	0.0937 mL	0.4685 mL	0.9370 mL	2.3425 mL
	40 mM	0.0703 mL	0.3514 mL	0.7027 mL	1.7569 mL
	50 mM	0.0562 mL	0.2811 mL	0.5622 mL	1.4055 mL
	60 mM	0.0468 mL	0.2342 mL	0.4685 mL	1.1712 mL