881001-19-0
Chemical Structure
EGFR/ErbB-2/ErbB-4 inhibitor-3
- CAS No.: 881001-19-0
- Formula:C17H11ClFN5O
- Molecular Weight:355.75
IUPAC Name: N-(4-((3-chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)but-2-ynamide
InChIKey: DLPSDPPZXRJQOY-UHFFFAOYSA-N
SMILES: O=C(C#CC)NC1=CC(C(NC(C=C2)=CC(Cl)=C2F)=NC=N3)=C3C=N1
Biological Activity: EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively[1]. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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EGFR/ErbB-2/ErbB-4 inhibitor-3 | 96.78% | EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard) | ≥98% | EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard) is the analytical standard of EGFR/ErbB-2/ErbB-4 inhibitor-3 (HY-103440). This product is intended for research and analytical applications. EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC50s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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