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Cat. No.: HY-103440R

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EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard)

EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard) is the analytical standard of EGFR/ErbB-2/ErbB-4 inhibitor-3 (HY-103440). This product is intended for research and analytical applications. EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC₅₀s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively. EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 881001-19-0
Formula: C₁₇H₁₁ClFN₅O
Molecular Weight:355.75

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Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard) Chemical Structure

CAS No.: 881001-19-0

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 881001-19-0
Molecular Weight 355.75
Formula C₁₇H₁₁ClFN₅O
SMILES

O=C(C#CC)NC1=CC(C(NC(C=C2)=CC(Cl)=C2F)=NC=N3)=C3C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Klutchko SR, et al. Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J Med Chem. 2006 Feb 23;49(4):1475-85. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard)

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EGFR/ErbB-2/ErbB-4 inhibitor-3 (Standard)