2. One-stop Drug Screening
  3. Screening Libraries
  4. Fragment Libraries
  5. According to Fragment Structures
  6. Sulfonyl Fluoride Fragment Library
Sulfonyl Fluoride Fragment Library

Cat. No.: HY-L945

Sulfonyl fluoride (-SO₂F) overcomes the poor target selectivity of traditional covalent warheads that rely heavily on cysteine. With high stability and tunable electrophilicity under physiological conditions, it targets multiple nucleophilic residues including Lys, Tyr, Ser and His, offering expanded druggable space, lower off-target risks and prolonged efficacy. It is widely used in covalent inhibitors, molecular glues, PROTACs and chemical probes.

MCE has built a highly diverse sulfonyl fluoride fragment library with 1,162 structurally diverse, drug-like fragments. Designed for balanced reactivity, stability and compatibility, these molecules feature tunable electrophilicity, simple scaffolds and high derivatization potential. Combined with SuFEx click chemistry, the library enables efficient modular modification and rapid structure optimization.

Ideal for targeting non-cysteine residues, this library improves covalent screening and probe development efficiency, serving as a precise tool for early-stage covalent drug discovery and chemical biology research.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•    A unique collection of 1162 structurally diverse sulfonyl fluoride fragments with tunable electrophilicity and favorable drug-like properties, designed for the research and development of sulfonyl fluoride-based drugs and chemical biology tools..

•    Identified via substructure searchingAI-driven 2D/3D similarity screening, it is applied to the research of chemical biology tools and covalent drug discovery based on sulfonyl fluorides.

•    All compounds are available off the shelf.

•    All compounds are validated by LC-MS or NMR to ensure high purity and quality.

Product Details

Formulation:

A fragment library is designed for sulfonyl fluoride-based covalent drug development and probe development.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Shipping:Blue ice or dry ice

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    Product Name:
    Sulfonyl Fluoride Fragment Library
    Cat. No.:
    HY-L945
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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