2. Oligonucleotides
  3. Pegylated Lipids

Pegylated Lipids

PEG is usually conjugated to lipid molecules with covalent bond and mixes with other lipids to form lipid-based nanoparticles. PEG groups serve many purposes: they reduce particle size, prevent aggregation during storage, increase circulation time and reduce uptake by unintended targets such as red blood cells and macrophages. However, the increased proportion of PEG on the surface of the lipid-based nanoparticles may reduce the mechanical stability and induce the dissociation.

Pegylated Lipids (47):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138300
    ALC-0159 1849616-42-7 ≥98.0%
    ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient.
    ALC-0159
  • HY-112764
    DMG-PEG 2000 160743-62-4 ≥98.0%
    DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
    DMG-PEG 2000
  • HY-140739
    DSPE-PEG2000-Maleimide
    DSPE-PEG-Maleimide (MW 2000) is a PEG compound which composed of DSPE and maleimide groups. DSPE-PEG-Maleimide (MW 2000) can be used for compose liposomes.
    DSPE-PEG2000-Maleimide
  • HY-145411
    PEG2000-C-DMG ≥98.0%
    PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA.
    PEG2000-C-DMG
  • HY-112760
    PEG2000-DSPE 247925-28-6 ≥98.0%
    PEG2000-DSPE can be used for the preparation of stabilized nucleic acid-lipid particllipid particles (SNALPs). SNALPs represent some of the earliest and best functional siRNA-ABC nanoparticles described.
    PEG2000-DSPE
  • HY-154804
    DLin-M-C4-DMA 1226909-66-5 ≥98.0%
    DLin-M-C4-DMA (Compound MC4) is a cationic lipid. DLin-M-C4-DMA can be used for delivery of nucleic acids.
    DLin-M-C4-DMA
  • HY-144013H
    18:0 mPEG5000 PE ammonium 474922-77-5
    18:0 mPEG5000 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.
    18:0 mPEG5000 PE ammonium
  • HY-142979
    DSPE-PEG 2000 892144-24-0
    DSPE-PEG 2000 is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery.
    DSPE-PEG 2000
  • HY-125924
    DSPE-PEG-Amine (MW 2000) (ammonium) 474922-26-4 ≥98.0%
    DSPE-PEG-Amine (MW 2000) (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.
    DSPE-PEG-Amine (MW 2000) (ammonium)
  • HY-139385A
    mPEG-DSPE (MW 2000) (sodium) ≥99.0%
    mPEG-DSPE (MW 2000) sodium is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. mPEG-DSPE (MW 2000) sodium is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents.
    mPEG-DSPE (MW 2000) (sodium)
  • HY-139385
    mPEG-DSPE (MW 2000) 147867-65-0
    mPEG-DSPE (MW 2000) is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. mPEG-DSPE (MW 2000) is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents[1][2].
    mPEG-DSPE (MW 2000)
  • HY-144004
    DSPE-PEG2000-Mal ammonium 474922-22-0
    DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents.
    DSPE-PEG2000-Mal ammonium
  • HY-W441015
    DSPE-PEG-NHS (MW 3400) ≥98.0%
    DSPE-PEG-NHS (MW 3400) is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
    DSPE-PEG-NHS (MW 3400)
  • HY-W440988
    DOPE-mPEG (MW 2000)
    DOPE-mPEG (MW 2000) is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG (MW 2000) significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner.
    DOPE-mPEG (MW 2000)
  • HY-141892A
    DSPE-PEG Carboxylic acid sodium (MW 2000) 1403744-37-5
    DSPE-PEG Carboxylic acid sodium (MW 2000) is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG Carboxylic acid sodium (MW 2000) increases the blood circulation time of liposomes.
    DSPE-PEG Carboxylic acid sodium (MW 2000)
  • HY-140736
    DSPE-PEG-Biotin (MW 2000) 385437-57-0
    DSPE-PEG-Biotin (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Biotin (MW 2000)
  • HY-112768
    PEG2000-DMPE
    PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20.
    PEG2000-DMPE
  • HY-W440832
    DSPE-PEG-Azide (MW 2000) ≥98.0%
    DSPE-PEG-Azide (MW 2000) is an azide containing lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG-Azide (MW 2000) is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    DSPE-PEG-Azide (MW 2000)
  • HY-W440888
    DSPE-PEG-Folate (MW 2000)
    DSPE-PEG-Folate (MW 2000) is a PEG derivative containing folic acid. DSPE-PEG-Folate (MW 2000) has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate (MW 2000) form micelles/lipid bilayer and can be used to targeted drug delivery system research.
    DSPE-PEG-Folate (MW 2000)
  • HY-W440896
    DSPE-PEG-SH (MW 2000)
    DSPE-PEG-SH (MW 2000) is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
    DSPE-PEG-SH (MW 2000)