2. Oligonucleotides
  3. Pegylated Lipids

Pegylated Lipids

PEG is usually conjugated to lipid molecules with covalent bond and mixes with other lipids to form lipid-based nanoparticles. PEG groups serve many purposes: they reduce particle size, prevent aggregation during storage, increase circulation time and reduce uptake by unintended targets such as red blood cells and macrophages. However, the increased proportion of PEG on the surface of the lipid-based nanoparticles may reduce the mechanical stability and induce the dissociation.

Pegylated Lipids (468):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112764
    mPEG2000-DMG 160743-62-4 98.40%
    DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
    mPEG2000-DMG
  • HY-142979
    DSPE-PEG 2000 892144-24-0 99.95%
    DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. DSPE-PEG 2000 can be used to form micelles as nanoparticles for drug delivery.
    DSPE-PEG 2000
  • HY-140739
    DSPE-PEG2000-Maleimide sodium (purity>95%) 99.58%
    DSPE-PEG2000-Maleimide sodium (purity>95%) is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide sodium (purity>95%) can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration.
    DSPE-PEG2000-Maleimide sodium (purity>95%)
  • HY-138300
    ALC-0159 1849616-42-7 99.93%
    ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient.
    ALC-0159
  • HY-W441014
    DSPE-PEG2000-NHS 99.96%
    DSPE-PEG2000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG2000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG2000-NHS can be used in the study of drug delivery.
    DSPE-PEG2000-NHS
  • HY-180958
    Chlorohexane-PEG-clozapine 3104316-26-6
    Chlorohexane-PEG-clozapine is a HaloTag PROTAC degrader based on Clozapine (HY-14539). Chlorohexane-PEG-clozapine leads to a significant decrease in the luminescence intensity and protein level of Halo-Eluc.
    Chlorohexane-PEG-clozapine
  • HY-179677B
    DSPE-PEG5000-DT7
    DSPE-PEG5000-Mal-Cys-DT7 is a phospholipid-PEG conjugate. DSPE-PEG5000-Mal-Cys-DT7 utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles.
    DSPE-PEG5000-DT7
  • HY-144004
    DSPE-PEG2000-Mal ammonium 474922-22-0 99.90%
    DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents.
    DSPE-PEG2000-Mal ammonium
  • HY-W591381
    DSG-PEG2000 308805-39-2 99.97%
    DSG-PEG2000 (DSG-PEG2000 2000) is a type of polyethylene glycol grease. DSG-PEG2000 can be used to prepare liposomes[2].
    DSG-PEG2000
  • HY-W440835
    DSPE-PEG2000-DBCO 99.90%
    DSPE-PEG2000-DBCO is a phospholipid-PEG polymer that can be used to form micelles as lipid nanoparticles for drug delivery. DSPE-PEG2000-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DSPE-PEG2000-DBCO
  • HY-166648
    DSPE-PEG2000-Maleimide sodium (purity>99%) 99.97%
    DSPE-PEG2000-Maleimide sodium (purity>99%) is a functional lipid component and a thiol-reactive crosslinker. DSPE-PEG2000-Maleimide sodium (purity>99%) undergoes Michael addition with the thiol groups of thiolated or cyclic RGD peptides to form stable thioether bonds and DSPE-PEG2000-RGD. DSPE-PEG2000-Maleimide sodium (purity>99%) is applicable to research on drug delivery.
    DSPE-PEG2000-Maleimide sodium (purity>99%)
  • HY-125924
    DSPE-PEG-Amine, MW 2000 ammonium 474922-26-4 99.96%
    DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.
    DSPE-PEG-Amine, MW 2000 ammonium
  • HY-168374
    DSPE-PEG2000-Mannose 1829524-73-3
    DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume.
    DSPE-PEG2000-Mannose
  • HY-145411
    PEG2000-C-DMG 1443687-74-8 99.97%
    PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA.
    PEG2000-C-DMG
  • HY-140740
    DSPE-PEG5000-Maleimide 99.84%
    DSPE-PEG5000-Maleimide, is a linker lipid containing DSPE phospholipid and Maleimide. DSPE-PEG-Maleimide is used in the synthesis of liposomes, including HELDC liposomes, sterically stabilized liposomes, and immunoliposomes.
    DSPE-PEG5000-Maleimide
  • HY-167036
    DMG-PEG2000-Mal 3101670-33-8 99.58%
    DMG-PEG2000-Mal is a pegylated lipid with a molecular weight of 2000. DMG-PEG-Mal serves as a component of lipid nanoparticles for mRNA delivery.
    DMG-PEG2000-Mal
  • HY-140736
    DSPE-PEG2000-Biotin 385437-57-0 99.93%
    DSPE-PEG2000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG2000-Biotin
  • HY-W440832
    DSPE-PEG2000-azide 99.74%
    DSPE-PEG2000-azide is an azide containing lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG2000-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DSPE-PEG2000-azide
  • HY-112760
    18:0 mPEG2000 PE sodium 247925-28-6 98.0%
    18:0 mPEG2000 PE (DSPE-mPEG2000) sodium is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery.
    18:0 mPEG2000 PE sodium
  • HY-W440896
    DSPE-PEG2000-SH 99.82%
    DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
    DSPE-PEG2000-SH