1. Oligonucleotides
  2. Pegylated Lipids

Pegylated Lipids

PEG is usually conjugated to lipid molecules with covalent bond and mixes with other lipids to form lipid-based nanoparticles. PEG groups serve many purposes: they reduce particle size, prevent aggregation during storage, increase circulation time and reduce uptake by unintended targets such as red blood cells and macrophages. However, the increased proportion of PEG on the surface of the lipid-based nanoparticles may reduce the mechanical stability and induce the dissociation.

Pegylated Lipids (8):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112764
    DMG-PEG 2000 160743-62-4 ≥98.0%
    DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
    DMG-PEG 2000
  • HY-125924
    DSPE-PEG(2000)-Amine 474922-26-4 ≥98.0%
    DSPE-PEG(2000)-Amine, an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.
    DSPE-PEG(2000)-Amine
  • HY-112760
    PEG2000-DSPE ≥98.0%
    PEG2000-DSPE can be used for the preparation of stabilized nucleic acid-lipid particllipid particles (SNALPs). SNALPs represent some of the earliest and best functional siRNA-ABC nanoparticles described.
    PEG2000-DSPE
  • HY-145411
    PEG2000-C-DMG ≥98.0%
    PEG2000-C-DMG, a lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA.
    PEG2000-C-DMG
  • HY-140739
    DSPE-PEG-Maleimide (MW 2000) ≥98.0%
    DSPE-PEG-Maleimide (MW 2000) is a PEG compound which composed of DSPE and maleimide groups. DSPE-PEG-Maleimide (MW 2000) can be used for compose liposomes.
    DSPE-PEG-Maleimide (MW 2000)
  • HY-139385A
    MPEG-2000-DSPE sodium
    MPEG-2000-DSPE sodium is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. MPEG-2000-DSPE sodium is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents.
    MPEG-2000-DSPE sodium
  • HY-144010
    18:1 PEG-PE 474922-90-2
    18:1 PEG-PE is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG-PE can be used for drug delivery.
    18:1 PEG-PE
  • HY-139385
    MPEG-2000-DSPE ≥99.0%
    MPEG-2000-DSPE is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. MPEG-2000-DSPE is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents.
    MPEG-2000-DSPE