2. Oligonucleotides
  3. Pegylated Lipids

Pegylated Lipids

PEG is usually conjugated to lipid molecules with covalent bond and mixes with other lipids to form lipid-based nanoparticles. PEG groups serve many purposes: they reduce particle size, prevent aggregation during storage, increase circulation time and reduce uptake by unintended targets such as red blood cells and macrophages. However, the increased proportion of PEG on the surface of the lipid-based nanoparticles may reduce the mechanical stability and induce the dissociation.

Pegylated Lipids (105):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138300
    ALC-0159 1849616-42-7 ≥98.0%
    ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient.
    ALC-0159
  • HY-112764
    DMG-PEG 2000 160743-62-4 ≥98.0%
    DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
    DMG-PEG 2000
  • HY-140739
    DSPE-PEG2000-Maleimide
    DSPE-PEG2000-Maleimide is a PEG compound which composed of DSPE and maleimide groups. DSPE-PEG2000-Maleimide can be used for compose liposomes.
    DSPE-PEG2000-Maleimide
  • HY-142979
    DSPE-PEG 2000 892144-24-0
    DSPE-PEG 2000 is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery.
    DSPE-PEG 2000
  • HY-145411
    PEG2000-C-DMG ≥98.0%
    PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA.
    PEG2000-C-DMG
  • HY-W441014
    DSPE-PEG-NHS, MW 2000 ≥98.0%
    DSPE-PEG-NHS, MW 2000 is a pegylated phospholipid derivatives which can be used to prepare liposome or lipid nanoparticles for targeted drug delivery system, such as DNA or mRNA vaccine.
    DSPE-PEG-NHS, MW 2000
  • HY-112760
    18:0 mPEG2000 PE sodium 247925-28-6 ≥98.0%
    18:0 mPEG2000 PE sodium can be used for the preparation of stabilized nucleic acid-lipid particllipid particles (SNALPs). SNALPs represent some of the earliest and best functional siRNA-ABC nanoparticles described.
    18:0 mPEG2000 PE sodium
  • HY-125924
    DSPE-PEG-Amine, MW 2000 ammonium 474922-26-4 ≥98.0%
    DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.
    DSPE-PEG-Amine, MW 2000 ammonium
  • HY-144004
    DSPE-PEG2000-Mal ammonium 474922-22-0
    DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents.
    DSPE-PEG2000-Mal ammonium
  • HY-W440896
    DSPE-PEG-SH, MW 2000 99.39%
    DSPE-PEG-SH, MW 2000 is a pegylated phospholipid with thiol group which is reactive with maleimide to form a covalent thioether linkage. The amphiphatic polymer can form lipid bilayer in aqueous solution and be used to encapsulate agents for drug delivery system, such as mRNA vaccine.
    DSPE-PEG-SH, MW 2000
  • HY-140736
    DSPE-PEG-Biotin, MW 2000 385437-57-0
    DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-Biotin, MW 2000
  • HY-W440832
    DSPE-PEG-Azide, MW 2000 ≥98.0%
    DSPE-PEG-Azide, MW 2000 is an azide containing lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG-Azide, MW 2000 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    DSPE-PEG-Azide, MW 2000
  • HY-144009
    DSPE-PEG-Folate, MW 3350 1236288-25-7
    DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research.
    DSPE-PEG-Folate, MW 3350
  • HY-144012
    16:0 PEG2000 PE 474922-84-4 99.83%
    16:0 PEG2000 PE (DPPE-PEG2000) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo.
    16:0 PEG2000 PE
  • HY-141892A
    DSPE-PEG Carboxylic acid (sodium), MW 2000 1403744-37-5
    DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG Carboxylic acid (sodium), MW 2000 increases the blood circulation time of liposomes.
    DSPE-PEG Carboxylic acid (sodium), MW 2000
  • HY-140740
    DSPE-PEG-Maleimide, MW 5000
    DSPE-PEG-Maleimide, MW 5000 has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-maleimide extends blood circulation time and higher stability for encapsulated agents.
    DSPE-PEG-Maleimide, MW 5000
  • HY-144006
    14:0 PEG2000 PE 474922-82-2 99.71%
    14:0 PEG2000 PE (DMPE-PEG2000) is a PEG-phospholipid conjugate to prepare nanostructured lipid carrier.
    14:0 PEG2000 PE
  • HY-W440988
    DOPE-mPEG, MW 2000
    DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner.
    DOPE-mPEG, MW 2000
  • HY-W440888
    DSPE-PEG-Folate, MW 2000
    DSPE-PEG-Folate, MW 2000 is a PEG derivative containing folic acid. DSPE-PEG-Folate, MW 2000 has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate, MW 2000 form micelles/lipid bilayer and can be used to targeted drug delivery system research.
    DSPE-PEG-Folate, MW 2000
  • HY-112768
    PEG2000-DMPE
    PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20.
    PEG2000-DMPE