474922-26-4
474922-26-4
Chemical Structure
DSPE-PEG-Amine, MW 2000 ammonium
Synonym(s): DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium
- CAS No.: 474922-26-4
- Formula:(C2H4O)nC44H87N2O10P.NH3
- Molecular Weight:2000 (Average)
SMILES: CCCCCCCCCCCCCCCCCC(OC[C@]([H])(COP(OCCNC(OCCN)=O)(O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O.[n].N
Biological Activity: DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSPE-PEG-Amine, MW 2000 ammonium | 99.96% | DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents. | ||||||||||||||||||||
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DSPE-PEG-Amine, MW 3400 ammonium | 99.21% | DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research. | ||||||||||||||||||||
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DSPE-PEG20000-Amine ammonium | DSPE-PEG20000-Amine ammonium is an amine derivative of phospholipid-polyethylene glycol, which is used to synthesize solid lipid and thermosensitive liposome nanoparticles for the delivery of anticancer agents. DSPE-PEG20000-Amine ammonium is applicable for cancer research. | |||||||||||||||||||||
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DSPE-PEG10000-Amine ammonium | DSPE-PEG10000-Amine ammonium is a phosphoethanolamine involved in the synthesis of liposomes for delivery systems. The amino group of DSPE-PEG10000-Amine ammonium can be converted into aromatic aldehydes by reacting with acetone-protected aromatic hydrazines on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes form a liposome-BAH-BCA conjugate by forming a bisarylhydrazone (BAH) with the target enzyme molecule. The conjugate catalyzes the hydration of carbon dioxide to bicarbonate. | |||||||||||||||||||||
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DSPE-PEG1000-Amine ammonium | 99.48% | DSPE-PEG1000-Amine (DSPE-PEG1000-NH2) ammonium is a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol conjugate with a terminal amino group. DSPE-PEG1000-Amine ammonium can functionalize the surface of PLGA-lecithin-PEG core-shell nanoparticles to introduce positive surface charges. The amino group of DSPE-PEG1000-Amine ammonium can be converted into an aromatic aldehyde to react with the acetone-protected aromatic hydrazide on the surface of bovine carbonic anhydrase (BCA) molecules. | ||||||||||||||||||||
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DSPE-PEG5000-Amine ammonium | DSPE-PEG5000-Amine ammonium (DSPE-PEG5000-NH2 ammonium) is an amino-functionalized PEGylated lipid. DSPE-PEG5000-Amine ammonium can be conjugated with chlorin e6 (Ce6) via EDC/NHS coupling. It can also be conjugated with FITC to prepare DSPE-PEG-FITC. DSPE-PEG5000-Amine ammonium is applicable to research related to PEGylated lipid functionalization and bioconjugation. | |||||||||||||||||||||
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References
- [1]. Gao J, et al. Affibody-based nanoprobes for HER2-expressing cell and tumor imaging. Biomaterials. 2011;32(8):2141-2148. [Content Brief]
- [2]. Farinha D, et al. Combination of Gene Therapy and Chemotherapy in a New Targeted Hybrid Nanosystem to Hepatocellular Carcinoma. Int J Nanomedicine. 2024;19:12505-12527. Published 2024 Nov 22. [Content Brief]
- [3]. Nandi D, et al. Nanoreporter for Real-Time Monitoring of Inflammasome Activity and Targeted Therapy. Adv Sci (Weinh). 2023;10(6):e2204900. [Content Brief]
