DSPE-PEG2000-TCO
Based on 1 Customer Validation
DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.96%
- CAS 番号: 1480940-53-1
- 分子式: (C2H4O)nC53H99N2O12P
- 分子量:2000 (Average)
-
保管条件:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
体外実験
DSPE-PEG2000-TCO forms micelles with Cetuximab (HY-P9905) that modify LNPs to mediate EGFR-dependent, near-complete (97-99%) transfection of HeLa cells with GFP mRNA, achieving 3-fold higher MFI than untargeted controls, with dose-dependent increases in intracellular mRNA payload and sensitivity to soluble Cetuximab inhibition[1].
LNPs containing DSPE-PEG2000-TCO, functionalized with αAPN-VHH, are transcytosed across the porcine intestinal epithelial barrier in apical-out enteroids, with mRNA delivered to both epithelial and subepithelial compartments resulting in GFP expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1480940-53-1
-
性状 Solid
-
分子量 2000 (Average)
-
分子式 (C2H4O)nC53H99N2O12P
-
Color White to light yellow
-
SMILES
O=C(OCCOCCNC(OC1CCC/C=C/CC1)=O)NCCOP(O)(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[n]
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
純度とドキュメンテーション
-
データシート (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Patel J, et al. Preparation of Targeted Lipid Nanoparticles by Insertion of Either Tetrazine-trans-Cyclooctene or Thiol-Maleimide Micelles. Bioconjug Chem. 2026;37(2):406-417. [Content Brief]
[2]. Chen L, et al. Cell-specific mRNA delivery via nanobody-functionalized lipid nanoparticles. J Control Release. 2025;388(Pt 2):114365. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DSPE-PEG2000-TCO 関連分類
HY-170704 関連分類
Powered by Bioz