1480940-53-1
Chemical Structure
DSPE-PEG2000-TCO
- CAS No.: 1480940-53-1
- Formula:(C2H4O)nC53H99N2O12P
- Molecular Weight:2000 (Average)
SMILES: O=C(OCCOCCNC(OC1CCC/C=C/CC1)=O)NCCOP(O)(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O.[n]
Biological Activity: DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSPE-PEG2000-TCO | 99.96% | DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis. | ||||||||||||||||||||
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References
- [1]. Patel J, et al. Preparation of Targeted Lipid Nanoparticles by Insertion of Either Tetrazine-trans-Cyclooctene or Thiol-Maleimide Micelles. Bioconjug Chem. 2026;37(2):406-417. [Content Brief]
- [2]. Chen L, et al. Cell-specific mRNA delivery via nanobody-functionalized lipid nanoparticles. J Control Release. 2025;388(Pt 2):114365. [Content Brief]
