1. Signaling Pathways
  2. Immunology/Inflammation
  3. FLAP

FLAP

FLAP (Arachidonate 5-lipoxygenase-activating protein) is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease. Leukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.

FLAP Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-14166
    MK-886 Inhibitor 99.77%
    MK-886 (L 663536) is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).
  • HY-15874
    Fiboflapon Inhibitor 98.18%
    Fiboflapon (GSK2190915) is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM.
  • HY-15874A
    Fiboflapon sodium Inhibitor 99.08%
    Fiboflapon sodium (GSK2190915 (sodium salt)) is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor with binding IC50 of 2.9 nM.
  • HY-50714
    Quiflapon sodium Inhibitor 99.25%
    Quiflapon sodium (MK591) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor.
  • HY-10037
    MK591 free acid Inhibitor 99.44%
    MK591 (free acid) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50 value of 1.6 nM in a FLAP binding assay.
  • HY-14460
    AM679 Inhibitor 99.98%
    AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.
  • HY-14163
    AM 103 Inhibitor
    AM 103 is a potent and selective FLAP inhibitor, with an IC50 value of 4.2 nM.
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