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FEN1-IN-3 

Cat. No.: HY-136484
Handling Instructions

FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM.

For research use only. We do not sell to patients.

FEN1-IN-3 Chemical Structure

FEN1-IN-3 Chemical Structure

CAS No. : 2109805-87-8

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Description

FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1].

In Vitro

FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1].

Molecular Weight

284.27

Formula

C₁₅H₁₂N₂O₄

CAS No.

2109805-87-8

SMILES

O=C(N1O)N(C2=CC=C(OC)C=C2)C3=C(C=CC=C3)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (879.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5178 mL 17.5889 mL 35.1778 mL
5 mM 0.7036 mL 3.5178 mL 7.0356 mL
10 mM 0.3518 mL 1.7589 mL 3.5178 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FEN1-IN-3OthershumanflapendonucleasehFEN1coloncancercellsglioblastomacolorectalInhibitorinhibitorinhibit

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FEN1-IN-3
Cat. No.:
HY-136484
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