2. Recombinant Proteins
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. ROR family

ROR family

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The receptor tyrosine kinase-like orphan receptors (ROR) family of receptor tyrosine kinases (RTKs) are type I transmembrane protein tyrosine kinases, characterized by their extracellular Frizzled-like cysteine-rich domains (CRDs) and membrane-proximal Kringle domains. RORs are originally identified as orphan receptor tyrosine kinases whose tyrosine kinase domains are highly similar to those of the Trk family. RORs are evolutionary conserved throughout the animal kingdom and act as alternative receptors and co-receptors of WNT ligands. In vertebrate, the Ror-family RTKs consist of two structurally related members, Ror1 and Ror2. The intracellular signaling cascades activated downstream of ROR receptors are diverse, including but not limited to ROR-Frizzled-mediated activation of planar cell polarity signaling, RTK-like signaling, and antagonistic regulation of WNT/β-Catenin signaling. RORs function in developmental processes including skeletal and neuronal development, cell movement and cell polarity.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P73390
    ROR1 Protein, Human (sf9, His)

    Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1

    		Human Sf9 insect cells
    ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ROR1 Protein, Human (sf9, His) is 331 a.a., with molecular weight of 55-70 kDa.
  • HY-P70732
    ROR1 Protein, Human (HEK293, His)

    Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1

    		Human HEK293
    ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (HEK293, His) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ROR1 Protein, Human (HEK293, His) is 374 a.a., with molecular weight of 60-80 kDa.
  • HY-P72410
    ROR1 Protein, Human (Biotinylated, HEK293, His-Avi)

    Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophictyrosine kinase, receptor-related 1; NTRKR1

    		Human HEK293
    ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is 374 a.a., with molecular weight of 55-80 kDa.
  • HY-P78617
    ROR1 Protein, Rat (HEK293, His)

    ROR1; NTRKR1

    		Rat HEK293
    ROR1 Protein, a crucial member of the Tyr protein kinase family within the protein kinase superfamily, plays a key role in cellular signaling and regulation as a tyrosine kinase. Its classification emphasizes its significance in phosphorylation events, sharing conserved features with related kinases. Studying ROR1 contributes to understanding its unique enzymatic functions and potential therapeutic applications. Further exploration promises insights into its broader impact on cellular signaling pathways and contributions to normal physiology and pathological conditions. ROR1 Protein, Rat (HEK293, His) is the recombinant rat-derived ROR1 protein, expressed by HEK293, with C-10*His labeled tag. The total length of ROR1 Protein, Rat (HEK293, His) is 374 a.a., with molecular weight of 60-75 kDa.
  • HY-P78510
    ROR1 Protein, Human (HEK293, His-Avi)

    ROR1; NTRKR1; dJ537F10.1

    		Human HEK293
    ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ROR1 Protein, Human (HEK293, His-Avi) is 374 a.a., with molecular weight of 55-70 kDa.
  • HY-P77825
    ROR1 Protein, Canine (HEK293, His)

    ROR1; NTRKR1; dJ537F10.1

    		Canine HEK293
    ROR1 protein is an important member of the Tyr protein kinase family in the protein kinase superfamily and plays a key role as a tyrosine kinase in cell signaling and regulation. Its classification emphasizes its importance in phosphorylation events and shares conserved features with related kinases. ROR1 Protein, Canine (HEK293, His) is the recombinant canine-derived ROR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ROR1 Protein, Canine (HEK293, His) is 456 a.a., with molecular weight of 65-68 kDa.
  • HY-P78032
    ROR1 Protein, Mouse (HEK293, His)

    ROR1; NTRKR1; dJ537F10.1

    		Mouse HEK293
    ROR1 protein shows minimal kinase activity in vitro, indicating an improbable role as a tyrosine kinase in vivo. It functions as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Additionally, ROR1 plays a vital role in the inner ear, aiding the innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ROR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of ROR1 Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 58-68 kDa.
Cat. No. Product Name Effect Purity