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ROR2 Protein, Mouse (HEK293, Fc)

The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Despite minimal tyrosine kinase activity, ROR2 phosphorylates YWHAB, which is associated with osteogenic induction and bone formation. ROR2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ROR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ROR2 Protein, Mouse (HEK293, Fc) is 370 a.a., with molecular weight of 70-100 kDa.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
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Biological Activity

Description

The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Despite minimal tyrosine kinase activity, ROR2 phosphorylates YWHAB, which is associated with osteogenic induction and bone formation. ROR2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ROR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ROR2 Protein, Mouse (HEK293, Fc) is 370 a.a., with molecular weight of 70-100 kDa.

Background

ROR2 protein, a tyrosine-protein kinase receptor, emerges as a key player in the early stages of chondrocyte formation and is indispensable for cartilage and growth plate development. This receptor demonstrates the capability to phosphorylate YWHAB, an event associated with the induction of osteogenesis and bone formation. Intriguingly, although it exhibits minimal tyrosine kinase activity in vitro, ROR2 is proposed to act as a receptor for the WNT ligand WNT5A, potentially exerting inhibitory effects on WNT3A-mediated signaling. The nuanced role of ROR2 underscores its involvement in intricate cellular processes during skeletal development.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-hFc
  • Accession

    Q9Z138-1 (E34-G403)

  • Gene ID
    26564  [NCBI]
  • Molecular Construction
    • N-term
    • ROR2 (E34-G403)
      Accession # Q9Z138
    • hFc
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    ROR2; Tyrosine-Protein Kinase Transmembrane Receptor ROR2; Prev. NTRKR2; Receptor Tyrosine Kinase-Like Orphan Receptor 2, Isoform CRA_b; Prev. BDB1; Neurotrophic Tyrosine Kinase, Receptor-Related 2; Prev. BDB; Neurotrophic Tyrosine Kinase Receptor-Related

  • AA Sequence

    EVEDSEAIDTLGQPDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQVEGPWCFTQNKNVRVELCDVPPCSPRDGSKMG

  • Predicted Molecular Mass

    67.6 kDa

  • Molecular Weight

    Approximately 70-100 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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