CD337/NCR3
CD337 is NKp30, encoded by NCR3, the natural cytotoxicity receptor that is constitutively expressed on mature human NK cells and serves as a key trigger of natural cytotoxicity against tumor cells. It contains a single extracellular Ig-like domain and in humans associates with CD3 zeta homodimers for signal transduction. Reported ligands include B7-H6 (encoded by NCR3LG1) on transformed cells and nuclear proteins such as BAT3/BAG6 released from stressed or dying cells, while the cytomegalovirus protein pp65 delivers an inhibitory interaction through NKp30. Splice variants and B7-H6 expression patterns influence NK function, and the NKp30 axis is studied for antitumor immunotherapy.
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CD337/NCR3 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
