IFN-α/β Receptor
IFN-α/β receptor is a type I IFN receptor which contains IFNAR1 and IFNAR2 two subunits. And IFNAR2 can form the heterodimeric receptor with IFNAR1, and binds to type I IFNs (such as IFN-α/-β). The association makes JAK1 and TYK2 form a functional signaling unit[1]. Upon activation by IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events. The signaling events includes the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2, and the formation of the ISGF3 complex which consists of phosphorylated STAT1 and STAT2 and IRF9[2][3]. IFN-α/β receptor is expressed on peripheral blood B cells and monocytes, and mediates differentiation and activation of these cells[4].
References:
- [1]. Zanin N, et al. Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Front Immunol. 2021 Jan 20;11:615603. [Content Brief]
- [2]. Shemesh M, et al. IFNAR1 and IFN-ALPHA/BETA R2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Sci Signal. 2021 Nov 23;14(710):eabe4627. [Content Brief]
- [3]. Jun Zou, et al. Chapter 7 - Antiviral Immunity: Origin and Evolution in Vertebrates. The Evolution of the Immune System. 2016,Pages 173-204.
- [4]. Pogue SL, et al. The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res. 2004 Feb;24(2):131-9. [Content Brief]
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IFN-α/β Receptor Recombinant Proteins (16)
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Inhibitors & Agonists (301)
IFNAR1 Protein, Human (Biotinylated, HEK293, His-Avi)
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Cat. No.: HY-P78141
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFN-alpha/beta R2 Protein, Human (HEK293, hFc)
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Cat. No.: HY-P74860
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
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IFNAR1 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P73127
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFN-alpha/beta R2 Protein, Human (HEK293, His, solution)
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Cat. No.: HY-P74862A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
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IFNAR1 Protein, Human (HEK293, His)
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Cat. No.: HY-P70483
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFN-alpha/beta R2 Protein, Human (HEK293, His)
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Cat. No.: HY-P72613
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
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IFN-alpha/beta R2 Protein, Mouse (HEK293, His)
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Cat. No.: HY-P78772
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
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IFN-alpha/beta R2 Protein, Cynomolgus (HEK293, His)
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Cat. No.: HY-P77392
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
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IFNAR1 Protein, Rhesus Macaque (HEK293)
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Cat. No.: HY-P76406
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFNAR1 Protein, Cynomolgus (HEK293, His)
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Cat. No.: HY-P70952
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFNAR1 Protein, Human (HEK293, His-Avi)
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Cat. No.: HY-P78457
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFNAR1 Protein, Mouse (HEK293, Fc)
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Cat. No.: HY-P78308
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFNAR1 Protein, Mouse (HEK293, His-Avi)
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Cat. No.: HY-P78309
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFN-alpha/beta R2 Protein, Human (Biotinylated, HEK293, His)
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Cat. No.: HY-P74861
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR2; IFN-R-2; Prev. IFNABR; Interferon-Alpha/Beta Receptor Beta Chain; Interferon Alpha/Beta Receptor 2; Human Interferon Alpha/Beta Receptor; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon (Alpha, Beta And Omega) Receptor 2; Inter
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IFNAR1 Protein, Human (HEK293, Fc)
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Cat. No.: HY-P74859
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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IFNAR1 Protein, Rhesus Macaque (HEK293, Fc)
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Cat. No.: HY-P76407
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNAR1; IFNalpha/Beta Receptor 1; Prev. IFNAR; Interferon-Alpha/Beta Receptor Alpha Chain; Interferon Alpha/Beta Receptor 1; Alpha-Type Antiviral Protein; Type I Interferon Receptor 1; Beta-Type Antiviral Protein; IFN-Alpha/Beta Receptor 1; Interferon-Bet
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Recombinant Protein Expression Service
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Capetin (28-54), human
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
