1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-α/β Receptor
  5. IFN-alpha/beta R2

IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor (IFN-α/β receptor) with IFNAR1, and binds to type I IFNs. IFN-α/-β can induce association of the IFNAR1 and IFN-alpha/beta R2, which makes JAK1 and TYK2 form a functional signaling unit[1]. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins[2]. Upon activation by IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events. The signaling events includes the phosphorylation of Tyk2 and JAK1, the signal transducers and activators of transcription STAT1 and STAT2, and the formation of the IFN-stimulated gene factor 3 (ISGF3) complex which consists of phosphorylated STAT1 and STAT2 and IRF9[3]. Human IFN-alpha/beta R2 consists of extracellular domain (I27-K243), helical domain (I244-L264), and cytoplasmic domain (K265-R515). Human IFN-alpha/beta R2 shares <50% aa sequence identity with mouse. IFN-alpha/beta R2 is expressed on peripheral blood B cells and monocytes, and mediates differentiation and activation of these cells[4].

Cat. No. Product Name / Synonyms Species Source
  • HY-P74860
    IFN-alpha/beta R2 Protein, Human (HEK293, hFc)

    Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB

    Human HEK293
    IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFN-alpha/beta R2 Protein, Human (HEK293, hFc) is a recombinant human IFN-alpha/beta R2 (I27-K243) with C-terminal hFc tag, which is produced in HEK293 cells.
  • HY-P74862A
    IFN-alpha/beta R2 Protein, Human (HEK293, His, solution)

    Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB

    Human HEK293
    IFN-α/β R2 protein forms a heterodimer with IFNAR1 and acts as a receptor for type I interferons. After interferon binding, the receptor subunit activates JAK, leading to the phosphorylation of STAT transcription factors. IFN-alpha/beta R2 Protein, Human (HEK293, His, solution) is the recombinant human-derived IFN-alpha/beta R2 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P72613
    IFN-alpha/beta R2 Protein, Human (HEK293, His)

    Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB

    Human HEK293
    IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFN-alpha/beta R2 Protein, Human (HEK293, His) is a recombinant human IFN-alpha/beta R2 (I27-K243) with C-terminal 6*His tag, which is produced in HEK293 cells.
  • HY-P77392
    IFN-alpha/beta R2 Protein, Cynomolgus (HEK293, His)

    Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB

    Cynomolgus HEK293
    IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFN-alpha/beta R2 Protein, Cynomolgus (HEK293, His) is a recombinant biotinylated cynomolgus IFN-alpha/beta R2 (M1-K243) with C-terminal His tag, which is produced in HEK293 cells.
  • HY-P78772
    IFN-alpha/beta R2 Protein, Mouse (HEK293, His)

    IFNAR2; IFNARB; IFNABR; IFN-R-2; IFN-alpha; beta receptor 2

    Mouse HEK293
    IFN-α/β R2 protein and IFNAR1 together constitute the heterodimeric receptor of type I interferon and initiate the JAK-STAT signaling cascade. Upon binding of type I interferons, IFNAR1 and IFNAR2 activate related Janus kinases (TYK2 and JAK1) in proximity, resulting in cross-phosphorylation. IFN-alpha/beta R2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IFN-alpha/beta R2 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of IFN-alpha/beta R2 Protein, Mouse (HEK293, His) is 221 a.a., with molecular weight of ~37-57 kDa.
  • HY-P701060
    IFNAR2 Protein, Cynomolgus (HEK293, His)

    IFN-R-2; IFNAR2; IFNARB; IFNABR; IFN-alpha; IFN-alpha/beta R2; IFNbR2; IFN-R; β receptor 2; β receptor10;

    Cynomolgus HEK293
  • HY-P74861
    IFN-alpha/beta R2 Protein, Human (Biotinylated, HEK293, His)

    Interferon alpha/beta receptor 2; IFN-R-2; Interferon alpha binding protein; IFNAR2; IFNABR; IFNARB

    Human HEK293
    IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2. IFN-alpha/beta R2 Protein, Human (Biotinylated, HEK293, His) is a recombinant biotinylated human IFN-alpha/beta R2 (I27-K243) with C-terminal His tag, which is produced in HEK293 cells.
Cat. No. Product Name Effect Purity