Cathepsin B
Best known among lysosomal cysteine cathepsins for its unusual dual specificity, Cathepsin B (CTSB) functions as both an endopeptidase and a carboxypeptidase, a property arising from a distinctive occluding loop that partially covers the active-site cleft. The enzyme is synthesized as a preproenzyme with a signal peptide and a propeptide, is activated in the acidic lysosomal environment, and is inhibited by cystatins and stefins. Elevated CTSB levels have been documented in numerous tumors, where the protease contributes to extracellular matrix degradation, invasion, and metastatic spread, and it also participates in processing of proinflammatory mediators such as pro-IL-1β.
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Cathepsin B Recombinant Proteins (5)
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Inhibitors & Agonists (35)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
