2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. SnRK

SnRK

Sucrose non-fermenting-1 (SNF1)-related protein kinase

SnRKs are a highly conserved family of serine/threonine protein kinases, homologous to yeast SNF1 and animal AMPK, and can be divided into three subtypes: SnRK1, SnRK2, and SnRK3. SnRK1 is regulated upstream by sugar/energy signals and SnAK/GRIK kinases, and downstream by nitrate reductase, sucrose phosphate synthase, and bZIP transcription factor. SnRK2 is regulated core-by-core by the ABA-PYR/PYL-PP2C module and targets AREB/ABF transcription factor and the SLAC1 channel. SnRK3 interacts with the CBL calcium receptor and targets ion transporters such as SOS1 and AKT1. This kinase family is primarily responsible for plant energy balance, abscisic acid signal transduction, and responses to abiotic stresses (drought, high salinity, low temperature, flooding, and nutrient deficiency). Functions such as response, maintenance of ion homeostasis and regulation of growth and development are the core molecular targets for crop stress resistance, disease resistance and yield improvement. Related research is mainly applied to the fields of plant stress biology and crop genetic improvement, such as agricultural crop stress resistance breeding, food security and climate adaptability improvement[1][2].

SnRK Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148062
    RSS0680
    		Degrader 98.03%
    RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].
    RSS0680
  • HY-164125
    6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose
    		Inhibitor
    6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose is an important signaling molecule that regulates carbon utilization and growth in plants. 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose releases T6P through light activation, which can stimulate starch synthesis and promote plant growth by inhibiting SnRK1, a protein kinase involved in energy conservation and survival. 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose can be used to study plant growth and metabolism.
    6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose