1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK6 Inhibitors

CDK6 Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform CDK6 together.

Please try each isoform separately.

CDK6 Specific Inhibitors
Product Name CDK6 CDK1 CDK2 CDK3 CDK4 CDK5 CDK7 CDK9 CDK6 Selectivity Purity
CP-10
CDK6, DC50: 2.1 nM
              Selective Inhibitor
Palbociclib
Cdk6/cyclin D2, IC50: 16 nM
     
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
      Pan Inhibitor 99.96%
Abemaciclib methanesulfonate
CDK6/cyclinD1, IC50: 10 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
CDK9/cyclinT1, IC50: 57 nM
Pan Inhibitor 99.95%
Palbociclib hydrochloride
Cdk6/cyclin D2, IC50: 16 nM
     
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
      Pan Inhibitor 99.94%
Ribociclib
CDK6, IC50: 39 nM
     
CDK4, IC50: 10 nM
      Pan Inhibitor 99.85%
Palbociclib isethionate
Cdk6/cyclin D2, IC50: 16 nM
     
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
      Pan Inhibitor 99.96%
Abemaciclib
CDK6/cyclinD1, IC50: 10 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
CDK9/cyclinT1, IC50: 57 nM
Pan Inhibitor 99.69%
PF-06873600
CDK6, Ki: 0.16 nM
 
CDK2, Ki: 0.09 nM
 
CDK4, Ki: 0.13 nM
      Pan Inhibitor 99.98%
Ribociclib succinate
CDK6, IC50: 39 nM
     
CDK4, IC50: 10 nM
      Pan Inhibitor 99.93%
AZD-5438
cdk6-cyclin D3, IC50: 21 nM
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk7-cyclin H, IC50: 821 nM
cdk9-cyclin T, IC50: 20 nM
Pan Inhibitor 99.37%
AT7519
cdk6/cyclin D3, IC50: 170 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
CDK9/Cyclin T, IC50: 10 nM
Pan Inhibitor 98.15%
JNJ-7706621
CDK6/cyclinD1, IC50: 175 nM
Cdk1/cyclin B, IC50: 9 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
CDK3/Cyclin E, IC50: 58 nM
Cdk4/cyclin D1, IC50: 253 nM
      Pan Inhibitor 99.91%
Trilaciclib hydrochloride
cdk6/cyclin D3, IC50: 4 nM
     
Cdk4/cyclin D1, IC50: 1 nM
      Pan Inhibitor 99.24%
CDKI-73
CDK6, IC50: 37.68 nM
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
 
CDK4, IC50: 8.18 nM
 
CDK7, IC50: 134.26 nM
CDK9, IC50: 5.78 nM
Pan Inhibitor 99.58%
AT7519 Hydrochloride
cdk6/cyclin D3, IC50: 170 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
CDK9/Cyclin T, IC50: 10 nM
Pan Inhibitor 99.99%
Ribociclib hydrochloride
CDK6, IC50: 39 nM
     
CDK4, IC50: 10 nM
      Pan Inhibitor 99.83%
Lerociclib dihydrochloride
cdk6/cyclin D3, IC50: 2 nM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
CDK9/Cyclin T, IC50: 28 nM
Pan Inhibitor 98.45%
MC180295
cdk6-cyclin D3, IC50: 712 nM
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
CDK7-CycH/MAT1, IC50: 555 nM
CDK9- Cyclin T1, IC50: 5 nM
Pan Inhibitor 98.47%
ON123300
CDK6/cyclinD1, IC50: 9.82 nM
     
Cdk4/cyclin D1, IC50: 3.87 nM
      Pan Inhibitor
AMG 925
CDK6, IC50: 8 nM
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
      Pan Inhibitor 99.33%
Ribociclib succinate hydrate
CDK6, IC50: 39 nM
     
CDK4, IC50: 10 nM
      Pan Inhibitor 99.00%
NVP-LCQ195
cdk6/cyclin D3, IC50: 187 nM
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
CDK9/cyclinT1, IC50: 15 nM
Pan Inhibitor 98.99%
FN-1501
CDK6/cyclinD1, IC50: 1.96 nM
 
cdk2/cyclin A, IC50: 2.47 nM
 
Cdk4/cyclin D1, IC50: 0.85 nM
      Pan Inhibitor 98.41%
Voruciclib hydrochloride
CDK6/cycD1, Ki: 2.92 nM
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
   
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
Pan Inhibitor
AT7519 trifluoroacetate
cdk6/cyclin D3, IC50: 170 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
CDK9/Cyclin T, IC50: 10 nM
Pan Inhibitor 98.16%
AMG 925 HCl
CDK6, IC50: 8 nM
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
      Pan Inhibitor 98.01%
BS-181 hydrochloride
CDK6/cycD1, IC50: 47 μM
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
CDK9/cycT, IC50: 4.2 μM
Pan Inhibitor
CDK4/6-IN-3
CDK6, Ki: 2.2 nM
CDK1, Ki: 110 nM
   
CDK4, Ki: 0.3 nM
      Pan Inhibitor
Riviciclib hydrochloride
cdk6-cyclin D3, IC50: 0.396 μM
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
Pan
CDK9-IN-7
CDK6/cyclinD, IC50: 145 nM
     
CDK4/cyclin D, IC50: 148 nM
   
CDK9/cyclinT1, IC50: 11 nM
Pan Inhibitor
Riviciclib
cdk6-cyclin D3, IC50: 0.396 μM
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
Pan Inhibitor
Lerociclib
cdk6/cyclin D3, IC50: 2 nM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
CDK9/Cyclin T, IC50: 28 nM
Pan Inhibitor
CDK4/6-IN-2
CDK6, IC50: 16 nM
     
CDK4, IC50: 2.7 nM
      Pan Inhibitor 99.82%
Abemaciclib Metabolites M2
CDK6, IC50: 1-3 nM
     
CDK4, IC50: 1-3 nM
      Pan Inhibitor
Nimbolide
CDK6
     
CDK4
      Pan Inhibitor