1. Cell Cycle/DNA Damage
  2. CDK

CT7001 hydrochloride (Synonyms: ICEC0942 hydrochloride)

Cat. No.: HY-103712A Purity: 99.98%
Handling Instructions

CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.

For research use only. We do not sell to patients.

CT7001 hydrochloride Chemical Structure

CT7001 hydrochloride Chemical Structure

CAS No. : 1805789-54-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.

IC50 & Target[1]

CDK7/CycH/MAT1

41 nM (IC50)

CDK2/cycE1

578 nM (IC50)

In Vitro

CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 62.5 mg/mL (145.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3203 mL 11.6017 mL 23.2035 mL
5 mM 0.4641 mL 2.3203 mL 4.6407 mL
10 mM 0.2320 mL 1.1602 mL 2.3203 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

References
Kinase Assay
[1]

The purified recombinant CDK2/cycE1 and CDK7/CycH/MAT1 are used in the assay. Kinase assays are performed. Briefly, Rb-CTF and RNA Polymerase II peptide is used for CDK2 and CDK7 kinase assays, respectively. A luciferase assay is used to determine ATP remaining at the end of the kinase reaction, which provides a measure of kinase activity. GraphPad Prism Software is used to generate the IC50 values for each CDK[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

430.97

Formula

C₂₂H₃₁ClN₆O

CAS No.

1805789-54-1

SMILES

O[[email protected]]1CNCC[[email protected]@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2.[H]Cl

Storage

4°C, stored under argon

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.98%

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
CT7001 hydrochloride
Cat. No.:
HY-103712A
Quantity:

CT7001 hydrochloride

Cat. No.: HY-103712A