Copy Link Print Information

Samuraciclib hydrochloride dihydrate

(Synonyms: CT7001 hydrochloride dihydrate; ICEC0942 hydrochloride dihydrate)
12 Cited Publications
Customer Review

Based on 12 publication(s) in Google Scholar

Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride hydrate inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 μM. Samuraciclib hydrochloride hydrate has anti-tumor effects.

For research use only. We do not sell to patients.

  • Purity: 99.90%
  • Formula: C22H30N6O.(2.5HCl).(2H2O)
  • Molecular Weight:521.70
  • Storage:

    4°C, stored under nitrogen, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

  • Samuraciclib hydrochloride dihydrate Chemical Structure
    Samuraciclib hydrochloride dihydrate Chemical Structure
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
  • Experimental Validation Results for Samuraciclib hydrochloride dihydrate
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Samuraciclib hydrochloride dihydrate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Samuraciclib hydrochloride dihydrate

More
Customer Validation & Images
In Vivo Efficacy StudyCell Proliferation/Viability AssayWBRT-PCR
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • WB
  • Cell Proliferation/Viability Assay
  • WB
  • RT-PCR

All CDK Isoforms

More
Keywords
100 mg

Get Quote In-stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Samuraciclib hydrochloride dihydrate Chemical Structure
    Samuraciclib hydrochloride dihydrate Chemical Structure
    1/16
  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2024 May 1;30(9):1889-1905. [Abstract]

    Customer Validation
     Tumor growth of ER-mutant PDX1526 in presence of vehicle, fulvestrant, Samuraciclib hydrochloride (samura) (30 mg/kg; P.O.; once daily), and fulvestrant + Samuraciclib hydrochloride (Ful+samura) for 28 days (mixed modelling with Tukey multiple comparisons test). Only significant P values are denoted.

  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: J Cancer Res Clin Oncol. 2023 Jul;149(8):5255-5263. [Abstract]

    Customer Validation
     Colony-formation assay. Samuraciclib (5, 10, 20, 50, 100 nM; 7 days) signifcantly inhibits the colony-formation ability of the two CRPC models (C4-2 and 22RV1).

  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Aug 9;10(8):602. [Abstract]

    Customer Validation
     HuCCT1 and HuH28 cells were treated with a novel CDK7 inhibitor Samuraciclib hydrochloride (ICEC0942) at different concentrations for 72 h. Cell viability was measured by CCK-8 assay.

  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Aug 9;10(8):602. [Abstract]

    Customer Validation
     HuCCT1 and HuH28 cells were exposed to Samuraciclib hydrochloride (ICEC0942) at indicated concentrations for 24 h. RNP2, RNP2 phosphorylation and MCL1 expression were analyzed by western blotting. ICEC0942 caused a dose-dependent reduction of phosphorylation of RNP2 at S2, S5, and S7.

  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. [Abstract]

    Customer Validation
     Dose–response curves of Hh-driven tumor lines and control cells in response to clinical trial used CDK7i compound Samuraciclib hydrochloride (CT7001). Cells were plated in 96-well plate in triplicate and treated with CT7001 at indicated concentrations for 72 h before cell viabilities were assessed. The results showed that CT7001 exhibited more potent inhibitory effect against Hh-driven tumor lines (IC50 ranging from ∼300 to 800 nM) compared with normal control neural cells (IC50 ranging from ∼1,300 to 2,100 nM).

  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. [Abstract]

    Customer Validation
     Immunoblot detecting phosphorylation levels at Ser2, Ser5, Ser7 of RNAPII C-terminal domain as well as Cdk7 and total RNAPII from Hh-driven cancer cell lines treated with Samuraciclib hydrochloride (CT7001) at indicated concentrations for 8 h. An anti–β-tubulin immunoblot is shown as loading control. CT7001 treatment induced dose-dependent reduction of phosphorylation at S2, S5, and S7 of RNAPII CTD.

  • 1/16

    Samuraciclib hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. [Abstract]

    Customer Validation
     qRT-PCR analysis of Gli1 and Gli2 in SmoWT-MB and SmoD477G-MB cells, as well as Gli1 in A673 and ATRT-03 cells. Cells were treated with DMSO or Samuraciclib hydrochloride (CT7001) at indicated concentrations for 8 h.

  • Samuraciclib hydrochloride dihydrate