1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK9 Inhibitors

CDK9 Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

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Sorry. There is currently no product that acts on isoform CDK9 together.

Please try each isoform separately.

CDK9 Specific Inhibitors
Product Name CDK9 CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK14 CDK16 CDK19 CDK9 Selectivity Purity
NVP-2
CDK9, IC50: 0.5 nM
                      Selective Inhibitor 99.29%
AZD4573
CDK9, IC50: 3 nM
                      Selective Inhibitor 99.80%
(+)-BAY-1251152
CDK9, IC50: 3 nM
                      Selective Inhibitor 99.66%
PHA-767491 hydrochloride
CDK9, IC50: 34 nM
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
            Selective Inhibitor 99.91%
LDC000067
CDK9- Cyclin T1, IC50: 44 nM
cdk1-cyclin B1, IC50: 5513 nM
cdk2-cyclin A, IC50: 2441 nM
 
cdk4-cyclin D1, IC50: 9242 nM
              Selective Inhibitor 98.14%
Atuveciclib
CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
CDK1/CycB(h), IC50: 1100 nM
CDK2/CycE(h), IC50: 1000 nM
CDK3/CycE(h), IC50: 890 nM
 
CDK5/p35(h), IC50: 1600 nM
            Selective Inhibitor 99.42%
CDK9-IN-1
CDK9/CycT1, IC50: 39 nM
                      Selective Inhibitor 95.48%
PROTAC CDK9 Degrader-1
CDK9
                      Selective Inhibitor 99.04%
MC180295
CDK9- Cyclin T1, IC50: 5 nM
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
        Selective Inhibitor 98.47%
CDK-IN-2
CDK9/cyclinT1, IC50: 8 nM
                      Selective Inhibitor 97.54%
JSH-150
CDK9/cyclinT1, IC50: 1 nM
Cdk1/cyclin B, IC50: 1.34 μM
cdk2/cyclin A, IC50: 2.86 μM
   
Cdk5/p25, IC50: 4.64 μM
 
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
 
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
  Selective Inhibitor 92.04%
CDK9 Antagonist-1
CDK9, IC50: 17 μM (MCF-7 cells)
                      Selective Inhibitor
CDK9-IN-7
CDK9/cyclinT1, IC50: 11 nM
     
CDK4/cyclin D, IC50: 148 nM
 
CDK6/cyclinD, IC50: 145 nM
          Selective Inhibitor
CDK9-IN-8
CDK9, IC50: 12 nM
                      Selective Inhibitor
PHA-767491
CDK9, IC50: 34 nM
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
            Selective Inhibitor
Abemaciclib methanesulfonate
CDK9/cyclinT1, IC50: 57 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
        Pan Inhibitor 99.95%
Dinaciclib
CDK9, IC50: 4 nM
CDK1, IC50: 3 nM
CDK2, IC50: 1 nM
   
CDK5, IC50: 1 nM
            Pan Inhibitor 99.73%
CYC065
CDK9
 
CDK2
                  Pan Inhibitor 99.78%
Abemaciclib
CDK9/cyclinT1, IC50: 57 nM
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
        Pan Inhibitor 99.69%
Atuveciclib Racemate
CDK9
                      Pan Inhibitor 98.48%
SNS-032
CDK9, IC50: 4 nM
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
 
CDK4, IC50: 925 nM
   
CDK7, IC50: 62 nM
        Pan Inhibitor 98.50%
AZD-5438
cdk9-cyclin T, IC50: 20 nM
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
        Pan Inhibitor 99.37%
AT7519
CDK9/Cyclin T, IC50: 10 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
        Pan Inhibitor 98.15%
CDKI-73
CDK9, IC50: 5.78 nM
CDK1, IC50: 8.17 nM
CDK2, IC50: 3.27 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
        Pan Inhibitor 99.58%
AT7519 Hydrochloride
CDK9/Cyclin T, IC50: 10 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
        Pan Inhibitor 99.99%
LY2857785
CDK9, IC50: 0.011 μM
           
CDK7, IC50: 0.246 μM
CDK8, IC50: 0.016 μM
      Pan Inhibitor 98.59%
SEL120-34A HCl
CDK9/cycT, IC50: 1070 nM
             
CDK8/CycC, IC50: 4.4 nM
   
CDK19/CycC, IC50: 10.4 nM
Pan Inhibitor 99.80%
SEL120-34A monohydrochloride
CDK9/cycT, IC50: 1070 nM
             
CDK8/CycC, IC50: 4.4 nM
   
CDK19/CycC, IC50: 10.4 nM
Pan Inhibitor 99.98%
Lerociclib dihydrochloride
CDK9/Cyclin T, IC50: 28 nM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
        Pan Inhibitor 98.45%
NVP-LCQ195
CDK9/cyclinT1, IC50: 15 nM
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
        Pan Inhibitor 98.99%
Voruciclib hydrochloride
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
          Pan Inhibitor
AT7519 trifluoroacetate
CDK9/Cyclin T, IC50: 10 nM
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
        Pan Inhibitor 98.16%
SEL120-34A
CDK9/cycT, IC50: 1070 nM
             
CDK8/CycC, IC50: 4.4 nM
   
CDK19/CycC, IC50: 10.4 nM
Pan Inhibitor
Roniciclib
CDK9/cyclinT1, IC50: 5 nM
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK4/cyclin D, IC50: 11 nM
   
CDK7/Cyclin H/MAT1, IC50: 25 nM
        Pan Inhibitor
BS-181 hydrochloride
CDK9/cycT, IC50: 4.2 μM
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
        Pan Inhibitor
CDK8/19-IN-1
CDK9, IC50: 270 nM
             
CDK8/CycC, IC50: 0.46 nM
   
CDK19/CycC, IC50: 0.99 nM
Pan Inhibitor
Riviciclib hydrochloride
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
          Pan
IIIM-290
CDK9/T1, IC50: 94 nM
 
CDK2/A, IC50: 90 nM
                  Pan Inhibitor
Riviciclib
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
          Pan Inhibitor
Lerociclib
CDK9/Cyclin T, IC50: 28 nM
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
        Pan Inhibitor
(-)-BAY-1251152
CDK9
                      default Inhibitor 99.82%