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Cat. No.: HY-130980

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N-Desmethyl FN-1501

N-Desmethyl FN-1501 (Compound 2) is a CDK2/9 ligand that can be used to synthesize PROTACs, such as PROTAC CDK2/9 Degrader-1 (HY-130709).

For research use only. We do not sell to patients.

CAS No.: 2183502-77-2
Formula: C₂₁H₂₃N₉O
Molecular Weight:417.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-Desmethyl FN-1501 Chemical Structure

CAS No.: 2183502-77-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

N-Desmethyl FN-1501 (Compound 2) is a CDK2/9 ligand that can be used to synthesize PROTACs, such as PROTAC CDK2/9 Degrader-1 (HY-130709)^[1].

IC₅₀ & Target

^[1]

CDK2

CDK9

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	0.053 μM Compound: 61	Growth inhibition of human MV4-11 cells after 72 hrs by CellTiter-Glo assay Growth inhibition of human MV4-11 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]

Chemical Information

CAS No. 2183502-77-2
Molecular Weight 417.47
Formula C₂₁H₂₃N₉O
SMILES

O=C(NC1=CC=C(C=C1)CN2CCNCC2)C3=NNC=C3NC4=C5C(NC=C5)=NC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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