1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK Inhibitors

CDK Inhibitors

CDK1

CDK2

CDK3

CDK4

CDK5

CDK6

CDK7

CDK8

CDK9

CDK11

CDK12

CDK13

CDK14

CDK16

CDK19

CDC

CLK

Pho85

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CDK Degraders, Inhibitors, Antagonists & Activators
Product Name CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 Purity
Palbociclib      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                        99.94%
Abemaciclib
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
CDK5/p35, IC50: 287 nM
Cdk5/p25, IC50: 355 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
                  99.96%
Ro-3306
CDK1, Ki: 20 nM
CDK1/cyclinB1, Ki: 35 nM
CDK1/cyclin A, Ki: 110 nM
CDK2/cyclinE, Ki: 340 nM
                                99.04%
Ribociclib      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                        99.98%
Dinaciclib
CDK1, IC50: 3 nM
CDK2, IC50: 1 nM
   
CDK5, IC50: 1 nM
     
CDK9, IC50: 4 nM
                  99.44%
Tagtociclib hydrate  
CDK2/cyclin E1, Ki: 1.16 nM
                                99.95%
Ebvaciclib  
CDK2, Ki: 0.09 nM
 
CDK4, Ki: 0.13 nM
 
CDK6, Ki: 0.16 nM
                        99.98%
GSK3326595      
CDK4
 
CDK6
                        99.97%
Palbociclib monohydrochloride      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                        99.98%
Flavopiridol
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
 
CDK4/Cyc D1, IC50: 100 nM
                            99.72%
Abemaciclib methanesulfonate
CDK1/cyclinB1, IC50: 1627 nM
CDK2/cyclinE, IC50: 504 nM
 
Cdk4/cyclin D1, IC50: 2 nM
Cdk5/p25, IC50: 355 nM
CDK5/p35, IC50: 287 nM
CDK6/cyclinD1, IC50: 10 nM
CDK7/Mat1/cyclinH1, IC50: 3910 nM
 
CDK9/cyclinT1, IC50: 57 nM
                  99.95%
(R)-Roscovitine
cdc2/cyclin B, IC50: 0.65 μM
cdk2/cyclin A, IC50: 0.7 μM
Cdk2/cyclin E2, IC50: 0.7 μM
   
CDK5/p35, IC50: 0.16 μM
                          99.84%
THZ1            
CDK7, IC50: 3.2 nM
                      99.84%
AZD4573                
CDK9, IC50: 4 nM
                  99.97%
THZ531            
CDK7, IC50: 8.5 μM
 
CDK9, IC50: 10.5 μM
 
CDK12, IC50: 158 nM
CDK13, IC50: 69 nM
            99.86%
SR-4835                    
CDK12, IC50: 99 nM
CDK12, Kd: 98 nM
CDK13, Kd: 4.9 nM
            99.73%
Kenpaullone
Cdk1/cyclin B, IC50: 0.4 μM
cdk2/cyclin A, IC50: 0.68 μM
CDK2/cyclinE, IC50: 7.5 μM
   
CDK5/p35, IC50: 0.85 μM
                          98.16%
Palbociclib isethionate      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                        99.99%
SY-5609  
CDK2, Ki: 2600 nM
       
CDK7, Kd: 0.065 nM
 
CDK9, Ki: 960 nM
 
CDK12, Ki: 870 nM
              99.66%
Wogonin              
CDK8
                    99.92%
GSK 3 Inhibitor IX
Cdk1/cyclin B, IC50: 320 nM
cdk2/cyclin A, IC50: 300 nM
 
Cdk4/cyclin D1, IC50: 10 μM
CDK5/p35, IC50: 80 nM
                          99.74%
SNS-032
CDK1, IC50: 480 nM
CDK2, IC50: 38 nM
 
CDK4, IC50: 925 nM
   
CDK7, IC50: 62 nM
 
CDK9, IC50: 4 nM
                  99.51%
Toyocamycin  
CDK2/cyclinA, IC50: 0.67 μM
 
Cdk4/cyclin D3, IC50: 15 μM
 
cdk6/cyclin D3, IC50: >10 μM
CDK7/Mat1/cyclinH1, IC50: 2.8 μM
 
CDK9/cyclinT1, IC50: 79 nM
                  99.90%
NVP-2                
CDK9, IC50: 0.5 nM
                  99.60%
Simurosertib                              
Cdc7, IC50: <0.3 nM
    99.07%
OTS964 hydrochloride                  
CDK11B, Kd: 40 nM
                99.74%
AT7519
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                  99.76%
PF-07220060      
Cdk4/cyclin D1, Ki: 0.6 nM
 
cdk6/cyclin D3, Ki: 13.9 nM
                        99.87%
Fadraciclib  
CDK2
           
CDK9
                  99.78%
JNJ-7706621
Cdk1/cyclin B, IC50: 9 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
CDK3/Cyclin E, IC50: 58 nM
Cdk4/cyclin D1, IC50: 253 nM
 
CDK6/cyclinD1, IC50: 175 nM
                        99.91%
KB-0742 dihydrochloride                
CDK9/cyclinT1, IC50: 6 nM
                  99.24%
Amantadine  
CDK2
                                99.90%
MBQ-167                              
Cdc42, IC50: 78 nM
    99.86%
AZD-5438
cdk1-cyclin B1, IC50: 16 nM
cdk2-cyclin E, IC50: 6 nM
cdk2-cyclin A, IC50: 45 nM
 
cdk4-cyclin D1, IC50: 449 nM
cdk5-p25, IC50: 14 nM
cdk6-cyclin D3, IC50: 21 nM
cdk7-cyclin H, IC50: 821 nM
 
cdk9-cyclin T, IC50: 20 nM
                  99.85%
Enitociclib                
CDK9/CycT1, IC50: 3 nM
                  99.66%
Flavopiridol Hydrochloride
CDK1/Cyc B1, IC50: 30 nM
CDK2/Cyc E, IC50: 170 nM
 
CDK4/Cyc D1, IC50: 100 nM
                            98.95%
TL12-186  
cdk2/cyclin A, IC50: 73 nM
           
CDK9/cyclinT1, IC50: 55 nM
                  99.63%
Samuraciclib hydrochloride
CDK1, IC50: 1.8 μM
CDK2, IC50: 578 nM
 
CDK4, IC50: 49 μM
CDK5, IC50: 9.4 μM
CDK6, IC50: 34 μM
CDK7, IC50: 41 nM
 
CDK9, IC50: 1.2 μM
                  99.98%
hSMG-1 inhibitor 11j
CDK1, IC50: 32 μM
CDK2, IC50: 7.1 μM
                                99.81%
Ribociclib hydrochloride      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                        99.95%
NG 52
cdc2-cyclin B, IC50: 0.34 μM
     
Pho85p, IC50: 2 nM
                          99.97%
BSJ-03-123          
CDK6
                        98.12%
BSJ-4-116                    
CDK12, IC50: 6 nM
              98.73%
XL413 monohydrochloride                              
Cdc7, IC50: 3.4 nM
    99.72%
BI-1347              
CDK8, IC50: 1.1 nM
                    98.95%
CPS2  
CDK2, IC50: 24 nM
                                99.33%
AS2863619              
CDK8, IC50: 0.61 nM
           
CDK19, IC50: 4.28 nM
      99.94%
SEL120-34A monohydrochloride              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
      98.69%
YKL-5-124  
CDK2, IC50: 1300 nM
       
CDK7, IC50: 53.5 nM
CDK7/Mat1/CycH, IC50: 9.7 nM
 
CDK9, IC50: 3020 nM
                  98.79%
TG003                                
CLK1, IC50: 20 nM
CLK2, IC50: 200 nM
CLK4, IC50: 15 nM
  99.55%
(E/Z)-Zotiraciclib  
CDK2, IC50: 13 nM
                                99.96%
PROTAC CDK2/9 Degrader-1  
CDK2, DC50: 62 nM
           
CDK9, DC50: 33 nM
                  99.85%
CVT-313
Cdk1/cyclin B, IC50: 4.2 μM
cdk2/cyclin A, IC50: 0.5 μM
 
Cdk4/cyclin D1, IC50: 215 μM
                            99.76%
BSJ-03-204      
CDK4/D1, IC50: 26.9 nM
 
CDK6/D1, IC50: 10.4 nM
                        99.76%
CGP60474
CDK1-Cyclin B, IC50: 26 nM
CDK2/cyclinE, IC50: 3 nM
cdk2/cyclin A, IC50: 4 nM
 
CDK4/cyclin D, IC50: 216 nM
Cdk5/p25, IC50: 10 nM
 
CDK7/cyclin H, IC50: 200 nM
 
CDK9/cycT, IC50: 13 nM
                  99.23%
Roniciclib
Cdk1/cyclin B, IC50: 7 nM
CDK2/cyclinE, IC50: 9 nM
 
CDK4/cyclin D, IC50: 11 nM
   
CDK7/Cyclin H/MAT1, IC50: 25 nM
 
CDK9/cyclinT1, IC50: 5 nM
                  98.03%
Milciclib
cyclin B/CDK1, IC50: 398 nM
cyclin A/CDK2, IC50: 45 nM
cyclin E/CDK2, IC50: 363 nM
 
cyclin D1/CDK4, IC50: 160 nM
   
cyclin H/CDK7, IC50: 150 nM
                      99.90%
AUZ 454  
CDK2(C118L/A144C), Kd: 9.7 nM
CDK2(A144C), Kd: 15.4 nM
CDK2(C118L), Kd: 18.6 nM
CDK2(WT), Kd: 50 nM
CDK2(C118L/A144C-Cyclin B), Kd: 134.1 nM
                                99.57%
Mevociclib            
CDK7
                      99.27%
CLK-IN-T3                                
CLK1, IC50: 0.67 nM
CLK2, IC50: 15 nM
CLK3, IC50: 110 nM
  98.63%
Casein Kinase inhibitor A51            
CDK7, Kd: 1.3 nM
 
CDK9, Kd: 4 nM
                  98.58%
MSC2530818              
CDK8, IC50: 2.6 nM
                    99.62%
FMF-04-159-2  
CDK2, IC50: 256 nM (in NanoBRET assay)
                   
CDK14/Cyclin Y, IC50: 39.6 nM (in NanoBRET assay)
          98.92%
Cucurbitacin E
cyclin B1/CDC2
                                  99.92%
R547
Cdk1/cyclin B, Ki: 2 nM
Cdk1/cyclin B, IC50: 0.2 nM
CDK2/cyclinE, Ki: 3 nM
cdk2/cyclin A, IC50: 0.1 nM
CDK2/cyclinE, IC50: 0.4 nM
CDK3/Cyclin E, IC50: 0.8 nM
CDK4/cyclin D, Ki: 1 nM
CDK5/p35, IC50: 0.1 nM
cdk6/cyclin D3, IC50: 4 nM
CDK7/cyclin H, IC50: 171 nM
                      99.57%
BSJ-04-132      
CDK4/D1, IC50: 50.6 nM
 
CDK6/D1, IC50: 30 nM
                        98.32%
Ribociclib succinate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                        99.93%
Palbociclib hydrochloride      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                        99.84%
CDK12-IN-3                    
CDK12, IC50: 491 nM
              99.57%
hSMG-1 inhibitor 11e
CDK1, IC50: 32 μM
CDK2, IC50: 7.1 μM
                                99.81%
PHA-767491 hydrochloride
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
                  98.06%
(R)​-​CR8
Cdk1/cyclin B, IC50: 0.09 μM
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
   
Cdk5/p25, IC50: 0.11 μM
 
CDK7/cyclin H, IC50: 1.1 μM
 
CDK9/Cyclin T, IC50: 0.18 μM
                  99.21%
CCT-251921              
CDK8, IC50: 2.3 nM
           
CDK19, IC50: 2.6 nM
      98.86%
THZ1 Hydrochloride            
CDK7, IC50: 3.2 nM
                      98.78%
Narazaciclib      
Cdk4/cyclin D1, IC50: 3.9 nM
 
CDK6/cyclinD1, IC50: 9.82 nM
                        99.12%
Senexin A              
CDK8, Kd: 0.83 μM
CDK8, IC50: 280 nM
           
CDK19, Kd: 0.31 μM
      99.85%
Purvalanol A
cdc2-cyclin B, IC50: 4 nM
cdk2-cyclin E, IC50: 35 nM
cdk2-cyclin A, IC50: 70 nM
 
cdk4-cyclin D1, IC50: 850 nM
cdk5-p35, IC50: 75 nM
                          98.30%
CDK5 inhibitor 20-223  
CDK2, IC50: 6.0 nM
   
CDK5, IC50: 8.8 nM
                          99.78%
BMS-265246
CDK1/cycB, IC50: 6 nM
CDK2/Cyc E, IC50: 9 nM
 
CDK4/cycD, IC50: 230 nM
                            98.92%
BS-181 hydrochloride
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
 
CDK9/cycT, IC50: 4.2 μM
                  99.80%
LDC000067
cdk1-cyclin B1, IC50: 5513 nM
cdk2-cyclin A, IC50: 2441 nM
 
cdk4-cyclin D1, IC50: 9242 nM
       
CDK9- Cyclin T1, IC50: 44 nM
                  98.00%
T025                                
CLK1, Kd: 4.8 nM
CLK2, Kd: 0.096 nM
CLK3, Kd: 6.5 nM
CLK4, Kd: 0.61 nM
  98.84%
XY028-140      
CDK4
 
CDK6
                        98.42%
Atuveciclib
CDK1/CycB(h), IC50: 1100 nM
CDK2/CycE(h), IC50: 1000 nM
CDK3/CycE(h), IC50: 890 nM
 
CDK5/p35(h), IC50: 1600 nM
     
CDK9/CycT1, IC50: 13 nM
CDK9/CycT1(h), IC50: 6 nM
                  99.80%
FN-1501  
cdk2/cyclin A, IC50: 2.47 nM
 
Cdk4/cyclin D1, IC50: 0.85 nM
 
CDK6/cyclinD1, IC50: 1.96 nM
                        99.08%
Asnuciclib
CDK1, IC50: 8.17 nM
CDK1, Ki: 4 nM
CDK2, IC50: 3.27 nM
CDK2, Ki: 3 nM
 
CDK4, IC50: 8.18 nM
 
CDK6, IC50: 37.68 nM
CDK7, IC50: 134.26 nM
CDK7, Ki: 91 nM
 
CDK9, IC50: 5.78 nM
CDK9, Ki: 4 nM
                  99.76%
Abemaciclib metabolite M2      
CDK4, IC50: 1.2 nM
 
CDK6, IC50: 1.3 nM
                        99.94%
PHA-793887
Cdk1/cyclin B, IC50: 60 nM
cdk2/cyclin A, IC50: 8 nM
CDK2/cyclinE, IC50: 8 nM
 
Cdk4/cyclin D1, IC50: 62 nM
Cdk5/p25, IC50: 5 nM
 
CDK7/cyclin H, IC50: 10 nM
 
CDK9/cyclinT1, IC50: 138 nM
                  99.25%
Amantadine hydrochloride  
CDK2
                                ≥98.0%
Purvalanol B
cdc2/cyclin B, IC50: 6 nM
cdk2/cyclin A, IC50: 6 nM
CDK2/cyclinE, IC50: 9 nM
   
CDK5/p35, IC50: 6 nM
                         
NU6300  
CDK2
                               
Nimbolide      
CDK4
 
CDK6
                        99.94%
SU9516
CDK1, IC50: 40 nM
CDK2, IC50: 22 nM
 
CDK4, IC50: 200 nM
                            99.81%
NU6102
Cdk1/cyclin B, IC50: 9.5 nM
CDK2/cyclin A3, IC50: 5.4 nM
 
CDK4, IC50: 1.6 μM
                            99.23%
(R)-CR8 trihydrochloride
CDK1/cyclinB1, IC50: 0.09 μM
cdk2/cyclin A, IC50: 0.072 μM
CDK2/cyclinE, IC50: 0.041 μM
   
Cdk5/p25, IC50: 0.11 μM
 
CDK7/cyclin H, IC50: 1.1 μM
 
CDK9/Cyclin T, IC50: 0.18 μM
                  98.95%
CP-10          
CDK6, DC50: 2.1 nM
                        98.22%
JSH-150
Cdk1/cyclin B, IC50: 1.34 μM
cdk2/cyclin A, IC50: 2.86 μM
   
Cdk5/p25, IC50: 4.64 μM
 
CDK7/Cyclin H/MNAT1, IC50: 1.72 μM
 
CDK9/cyclinT1, IC50: 1 nM
     
CDK14/Cyclin Y, IC50: 1.68 μM
CDK16/Cyclin Y, IC50: 292 nM
        98.36%
PF 477736
CDK1, Ki: 9.9 μM
                                  99.21%
RGB-286638
cyclin B1-CDK1, IC50: 2 nM
cyclin E-CDK2, IC50: 3 nM
cyclin E-CDK3, IC50: 5 nM
cyclin D1-CDK4, IC50: 4 nM
p35-CDK5, IC50: 5 nM
cyclin D3-CDK6, IC50: 55 nM
cyclin H-CDK7, IC50: 44 nM
 
T1-CDK9, IC50: 1 nM
                  99.84%
LDC4297            
CDK7, IC50: 0.13 nM
                      98.25%
Trilaciclib hydrochloride      
Cdk4/cyclin D1, IC50: 1 nM
 
cdk6/cyclin D3, IC50: 4 nM
                        99.74%
PROTAC CDK9 Degrader-1                
CDK9
                  98.03%
CDK12-IN-2  
CDK2, IC50: >100 μM
       
CDK7, IC50: >10 μM
CDK7, IC50: >10 μM
 
CDK9, IC50: 16 μM
 
CDK12, IC50: 52 nM
              99.44%
JH-XI-10-02              
CDK8, IC50: 159 nM
                    99.82%
CDK2-IN-4
Cdk1/cyclin B, IC50: 86 μM
cdk2/cyclin A, IC50: 44 nM
                                98.07%
CLK1-IN-1                                
CLK1, IC50: 2 nM
  98.79%
CKI-7 free base                              
Cdc7
    99.34%
BRD6989              
CDK8, IC50: ~200 nM
recombinant CDK8, IC50: ~0.5 μM
           
recombinant CDK19, IC50: >30 μM
      99.56%
Olomoucine  
cdk2-cyclin A, IC50: 7 μM
cdk2-cyclin E, IC50: 7 μM
   
cdk5-p35, IC50: 25 μM
                          99.78%
LY2857785            
CDK7, IC50: 0.246 μM
CDK8, IC50: 0.016 μM
CDK9, IC50: 0.011 μM
                  99.92%
CDK9-IN-2                
CDK9, IC50: 5 nM (H929 multiple myeloma cell line)
                  99.37%
CDK12-IN-E9  
cdk2/cyclin A, IC50: 932 nM
       
CDK7/Cyclin H/MNAT1, IC50: 1210 nM
 
CDK9/cyclinT1, IC50: 23.9 nM
                  99.97%
Lerociclib dihydrochloride
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 832 nM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
                  98.11%
Samuraciclib hydrochloride hydrate
CDK1, IC50: 1.8 μM
CDK2, IC50: 578 nM
 
CDK4, IC50: 49 μM
CDK5, IC50: 9.4 μM
CDK6, IC50: 31 μM
CDK7, IC50: 41 nM
 
CDK9, IC50: 1.2 μM
                  99.08%
Voruciclib
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
   
CDK9/cyc T2, Ki: 0.626 nM
CDK9/CycT1, Ki: 1.68 nM
                  99.77%
Thiabendazole
CCNE1
CDK2
                                99.72%
MC180295
CDK1-Cyclin B, IC50: 138 nM
cdk2-cyclin A, IC50: 233 nM
cdk2-cyclin E, IC50: 367 nM
CDK3-Cyclin E, IC50: 399 nM
CDK4-Cyclin D, IC50: 112 nM
cdk5-p35, IC50: 159 nM
cdk5-p25, IC50: 186 nM
cdk6-cyclin D3, IC50: 712 nM
CDK7-CycH/MAT1, IC50: 555 nM
 
CDK9- Cyclin T1, IC50: 5 nM
                  98.89%
CC-671                                
CLK2, IC50: 0.006 μM
  99.06%
TC11
CDK1
                                  98.04%
THZ2
CDK1, IC50: 96.9 nM
CDK2, IC50: 222 nM
   
CDK5, IC50: 134 nM
 
CDK7, IC50: 13.9 nM
CDK8, IC50: 6830 nM
CDK9, IC50: 194 nM
                  99.03%
Riviciclib hydrochloride
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.500 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
                  99.01%
Abemaciclib metabolite M20      
CDK4
 
CDK6
                       
EHT 5372                                
CLK1, IC50: 22.8 nM
CLK2, IC50: 88.8 nM
CLK4, IC50: 59.0 nM
  98.12%
GFB-12811  
CDK2/CycA, IC50: 211 nM
   
Cdk5/p25, IC50: 2.3 nM
 
CDK7/Cyclin H/MAT1, IC50: 718 nM
 
CDK9/CycT1, IC50: 894 nM
                  98.00%
HS-243                                
CLK4, IC50: 662 nM
  99.88%
ML167    
CDK3, IC50: >10000 nM
                         
CLK4, IC50: 136 nM
CLK1, IC50: 1522 nM
CLK2, IC50: 1648 nM
  98.62%
Abemaciclib metabolite M18 hydrochloride      
CDK4
 
CDK6
                        98.01%
LY3177833                              
Cdc7, IC50: 3.3 nM
    99.48%
AT7519 Hydrochloride
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                  99.42%
YKL-5-124 TFA  
CDK2, IC50: 1300 nM
       
CDK7, IC50: 53.5 nM
CDK7/Mat1/CycH, IC50: 9.7 nM
 
CDK9, IC50: 3020 nM
                  99.44%
Palbociclib-d8      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                        99.84%
XY028-133      
CDK4
 
CDK6
                        98.62%
Dalpiciclib hydrochloride      
CDK4, IC50: 12.4 nM
 
CDK6, IC50: 9.9 nM
                        99.92%
AMG 925
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                        98.20%
Bisindolylmaleimide X hydrochloride  
CDK2, IC50: 200 nM
                                99.35%
KH-CB19                                
CLK1, IC50: 19.7 nM
CLK3, IC50: 530 nM
  99.31%
DS96432529              
CDK8
                    99.79%
NU6140
CDK1-Cyclin B, IC50: 6.6 μM
cdk2-cyclin A, IC50: 0.41 μM
 
CDK4-Cyclin D, IC50: 5.5 μM
cdk5-p25, IC50: 15 μM
 
cdk7-cyclin H, IC50: 3.9 μM
                      99.07%
YX-2-107          
CDK6, IC50: 4.4 nM
                        99.79%
(-)-Enitociclib                
CDK9
                  99.81%
AZ5576                
CDK9, : <5 nM
                  99.88%
CDK-IN-2                
CDK9/cyclinT1, IC50: 8 nM
                  98.97%
NVP-LCQ195
Cdk1/cyclin B, IC50: 2 nM
cdk2/cyclin A, IC50: 2 nM
CDK2/cyclinE, IC50: 5 nM
CDK3/Cyclin E, IC50: 42 nM
 
Cdk5/p25, IC50: 1 nM
CDK5/p35, IC50: 1 nM
cdk6/cyclin D3, IC50: 187 nM
CDK7/Cyclin H/MAT1, IC50: 3564 nM
 
CDK9/cyclinT1, IC50: 15 nM
                  98.91%
SEL120-34A hydrochloride              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
      99.98%
PROTAC CDK12/13 Degrader-1 TFA                    
CDK12, DC50: 2.2 nM
CDK13, DC50: 2.1 nM
            98.37%
K00546
Cdk1/cyclin B, IC50: 0.6 nM
cdk2/cyclin A, IC50: 0.5 nM
                           
CLK1, IC50: 8.9 nM
CLK3, IC50: 29.2 nM
  98.08%
RSS0680
CDK1
CDK2
 
CDK4
 
CDK6
             
CDK16/Cyclin Y
        98.03%
CDK9-IN-1                
CDK9/CycT1, IC50: 39 nM
                 
CDK9-IN-7      
CDK4/cyclin D, IC50: 148 nM
 
CDK6/cyclinD, IC50: 145 nM
   
CDK9/cyclinT1, IC50: 11 nM
                  98.05%
Avotaciclib trihydrochloride
CDK1
                                  99.75%
AS2863619 free base              
CDK8, IC50: 0.61 nM
           
CDK19, IC50: 4.28 nM
      99.87%
Cimpuciclib tosylate      
CDK4, IC50: 0.49 nM
 
CDK6, IC50: 9.56 nM
                        99.16%
NSC 625987      
CDK4/D1, IC50: 0.2 μM
                            98.58%
Alsterpaullone
Cdk1/cyclin B, IC50: 35 nM
cdk2/cyclin A, IC50: 15 nM
CDK2/Cyc E, IC50: 200 nM
   
CDK5/p35, IC50: 40 nM
                          98.38%
FIT-039                
CDK9/cyclinT1, IC50: 5.8 μM
                  99.56%
BGG463  
CDK2
                                ≥98.0%
Casein Kinase inhibitor A86            
CDK7, Kd: 0.31 nM
 
CDK9, Kd: 5.4 nM
                  98.47%
Garcinone C            
CDK7
                      99.66%
ON-013100      
Cdk4/cyclin D1
                            98.66%
DB0614          
CDK6
             
CDK16/Cyclin Y
        98.80%
Samuraciclib hydrochloride hydrate
CDK1, IC50: 1.8 μM
CDK2/cycE1, IC50: 578 nM
 
CDK4, IC50: 49 μM
CDK5, IC50: 9.4 μM
CDK6, IC50: 34 μM
CDK7/CycH/MAT1, IC50: 41 nM
 
CDK9, IC50: 1.2 μM
                  99.88%
CDK5-IN-3  
CDK2/CycA, IC50: 18 nM
   
Cdk5/p25, IC50: 0.6 nM
                          98.00%
JH-XVI-178              
CDK8, IC50: 1 nM
           
CDK19, IC50: 2 nM
      98.16%
MeBIO
Cdk1/cyclin B, IC50: 55 μM
     
Cdk5/p25, IC50: >100 μM
                          ≥98.0%
Atuveciclib Racemate                
CDK9
                  98.48%
CDK8-IN-1              
CDK8, IC50: 3 nM
                    99.77%
Dalpiciclib      
CDK4, IC50: 12.4 nM
 
CDK6, IC50: 9.9 nM
                        99.40%
Senexin B              
CDK8, Kd: 140 nM
           
CDK19, Kd: 80 nM
      99.72%
THZ1-R            
CDK7, IC50: 146 nM
                      98.12%
Manzamine A hydrochloride        
CDK5, IC50: 1.5 μM
                          99.66%
CDK2-IN-3  
CDK2, IC50: 60 nM
                               
Longdaysin            
CDK7, IC50: 29 μM
                      99.87%
Ribociclib succinate hydrate      
CDK4, IC50: 10 nM
 
CDK6, IC50: 39 nM
                        99.96%
BI-1622                  
CDK11B
                98.97%
Ipivivint  
CDK2, EC50: 1 nM
CDK3, EC50: 7 nM
                              99.65%
CDK9-IN-8                
CDK9, IC50: 12 nM
                  99.65%
CDK4/6-IN-2      
CDK4, IC50: 2.7 nM
 
CDK6, IC50: 16 nM
                        99.82%
Bohemine  
CDK2/cyclinE, IC50: 4.6 μM
cdk2/cyclin A, IC50: 83 μM
           
CDK9/cyclinT1, IC50: 2.7 μM
                  98.93%
GSK-3 inhibitor 3  
CDK2, IC50: 0.22 μM
   
CDK5, IC50: 1.3 μM
                          98.72%
Senexin C              
CDK8/CycC, IC50: 3.6 nM
CDK8/CycC, Kd: 1.4 nM
           
CDK19/CycC, Kd: 2.9 nM
      98.06%
7BIO        
CDK5
                          ≥98.0%
CK7  
CDK2
           
CDK9
                  99.23%
NecroIr1      
CDK4
                            98.02%
KH-CB20                                
CLK1, IC50: 16.5 nM
CLK3, IC50: 488 nM
  99.80%
NU2058
CDK1, IC50: 26 μM
CDK2, IC50: 17 μM
CDK2, Ki: 12 μM
                                98.78%
CA224  
cdk2-cyclin A, IC50: 521 μM
 
cdk4-cyclin D1, IC50: 6.2 μM
                            99.94%
BSJ-01-175                    
CDK12
CDK13
            99.45%
(E/Z)-Zotiraciclib citrate  
CDK2
                                98.06%
LDC4297 hydrochloride            
CDK7, IC50: 0.13 nM
                      98.25%
CDK12-IN-5  
CDK2/cyclinE, IC50: 173 μM
           
CDK9/cyclinT1, IC50: 127 μM
 
CDK12, IC50: 23.9 nM
              99.01%
CDK1-IN-2
CDK1, IC50: 5.8 μM
                                 
(E/Z)-Zotiraciclib hydrochloride  
CDK2
                                99.45%
CDK4/6-IN-15  
CDK2, IC50: 3.335 μM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 0.279 μM
                       
CLK1-IN-3                                
CLK1, IC50: 5 nM
CLK2, IC50: 42 nM
CLK4, IC50: 108 nM
  98.03%
RGB-286638 free base
cyclin B1-CDK1, IC50: 2 nM
cyclin E-CDK2, IC50: 3 nM
cyclin E-CDK3, IC50: 5 nM
cyclin D1-CDK4, IC50: 4 nM
p35-CDK5, IC50: 5 nM
cyclin D3-CDK6, IC50: 55 nM
cyclin H-CDK7, IC50: 44 nM
 
T1-CDK9, IC50: 1 nM
                  98.87%
GW297361
yeast Cdk1, IC50: 20 nM
human CDK1, IC50: 30 nM
human CDK2, IC50: 1.9 nM
 
human CDK4, IC50: 300 nM
       
human CDK9, IC50: 10 nM
               
yeast Pho85, IC50: 400 nM
98.13%
Ca2+ channel agonist 1  
CDK2, EC50: 3.34 μM
                                99.71%
CAN508
Cdk1/cyclin B, IC50: 44 μM
CDK2/cyclinE, IC50: 20 μM
cdk2/cyclin A, IC50: 69 μM
 
Cdk4/cyclin D1, IC50: 13.5 μM
   
CDK7/cyclin H, IC50: 26 μM
 
CDK9/cyclinT1, IC50: 0.35 μM
                  99.59%
TP-1287                
CDK9
                 
CDK9 inhibitor HH1                
CDK9
                 
NU6027
CDK1, Ki: 2.5 μM
CDK2, Ki: 1.3 μM
                                99.04%
HTH-01-091            
CDK7, IC50: 1230 nM
                      98.64%
CDK8/19-IN-1              
CDK8/CycC, IC50: 0.46 nM
CDK9, IC50: 270 nM
         
CDK19/CycC, IC50: 0.99 nM
      98.03%
NecroIr2      
CDK4
                            98.99%
DB1113      
CDK4
         
CDK11B
                99.28%
PNU112455A hydrochloride  
CDK2, Km: 3.6 μM
   
CDK5, Km: 3.2 μM
                          99.56%
CDK8-IN-13              
CDK8, IC50: 51.9 nM
                    99.14%
Desmethylglycitein
CDK1
CDK2
                                98.98%
CDK9-IN-10                
CDK9
                  98.00%
Butyrolactone I
CDK1
                                  98.03%
LL-K8-22              
CDK8, DC50: 2.52 μM
                    99.76%
Voruciclib hydrochloride
CDK1/cycB, Ki: 5.4 nM
CDK1/cyc A, Ki: 9.1 nM
   
CDK4/Cyc D1, Ki: 3.96 nM
 
CDK6/cycD1, Ki: 2.92 nM
   
CDK9/CycT1, Ki: 1.68 nM
CDK9/cyc T2, Ki: 0.626 nM
                  99.23%
CDDD11-8                
CDK9, Ki: 8 nM
                  99.62%
CDK9-IN-13
CDK1, IC50: 0.14 μM
CDK2, IC50: 0.72 μM
       
CDK7, IC50: 0.40 μM
 
CDK9, IC50: <3 nM
 
CDK12, IC50: 0.055 μM
              99.22%
GW8510  
CDK2
   
CDK5
                          99.64%
CDK7-IN-21            
CDK7
                     
Lacto-N-fucopentaose I  
CDK2/cyclinE
                               
RGB-286147
CDK1/cyclinB, IC50: 48 nM
CDK2/E, IC50: 15 nM
 
CDK4/D1, IC50: 839 nM
 
cdk6/cyclin D3, IC50: 232 nM
                        ≥98.0%
Cdk1/2 Inhibitor III
Cdk1/cyclin B, IC50: 2.1 μM
                                  99.69%
AMG 925 HCl
CDK1, IC50: 1.9 μM
CDK2, IC50: 375 nM
 
CDK4, IC50: 3 nM
 
CDK6, IC50: 8 nM
                       
CDK8-IN-11              
CDK8, IC50: 46 nM
                    98.20%
5-Iodo-indirubin-3'-monoxime
Cdk1/cyclin B, IC50: 25 nM
     
Cdk5/p25, IC50: 20 nM
                          99.50%
Abemaciclib metabolite M20-d8      
CDK4
 
CDK6
                       
(S)-LY3177833 hydrate                              
Cdc7
   
IV-361  
CDK2, Ki: ≥1000 nM
       
CDK7, Ki: ≤50 nM
                      98.64%
LY3177833 monhydrate                              
Cdc7, IC50: 3.3 nM
    99.76%
Avotaciclib
CDK1
                                 
Lerociclib
CDK1/cyclinB1, IC50: 2.4 μM
cdk2/cyclin A, IC50: 1.5 μM
CDK2/cyclinE, IC50: 3.6 μM
 
Cdk4/cyclin D1, IC50: 1 nM
CDK5/p35, IC50: 0.832 μM
Cdk5/p25, IC50: 1.2 μM
cdk6/cyclin D3, IC50: 2 nM
CDK7/Cyclin H/MAT1, IC50: 2.4 μM
 
CDK9/Cyclin T, IC50: 28 nM
                 
BS-181
CDK1/cycB, IC50: 8.1 μM
CDK2/Cyc E, IC50: 0.88 μM
 
CDK4/Cyc D1, IC50: 33 μM
CDK5/p35NCK, IC50: 3 μM
CDK6/cycD1, IC50: 47 μM
CDK7/CycH/MAT1, IC50: 0.021 μM
 
CDK9/cycT, IC50: 4.2 μM
                  98.10%
PROTAC CDK12/13 Degrader-1                    
CDK12, DC50: 2.2 nM
CDK13, DC50: 2.1 nM
           
(E/Z)-BIO-acetoxime
CDK1/cyclinB, IC50: 63 μM
CDK2/cyclinA, IC50: 4.3 μM
   
Cdk5/p25, IC50: 2.4 μM
                         
NSC693868
Cdk1/cyclin B, IC50: 600 nM
     
Cdk5/p25, IC50: 400 nM
                          ≥99.0%
Akt1&PKA-IN-1  
CDK2, IC50: 9.8 μM
                               
Vanicoside B    
CDK3
                              99.82%
BS-194
CDK1, IC50: 30 nM
CDK2, IC50: 3 nM
   
CDK5, IC50: 30 nM
 
CDK7, IC50: 250 nM
 
CDK9, IC50: 90 nM
                  99.36%
Akt1&PKA-IN-2  
CDK2a, IC50: 0.69 μM
                               
CGP-82996
CDK1/cyclinB, IC50: >100 μM
CDK2/cyclinA, IC50: >50 μM
CDK2/cyclin E, IC50: >50 μM
 
Cdk4/cyclin D1, IC50: 1.5 μM
CDK4/cyclin D2, IC50: >50 μM
CDK5/p35, IC50: 25 μM
CDK6/cyclinD1, IC50: 5.6 μM
Cdk6/cyclin D2, IC50: >50 μM
                       
SEL120-34A              
CDK8/CycC, IC50: 4.4 nM
CDK9/cycT, IC50: 1070 nM
         
CDK19/CycC, IC50: 10.4 nM
     
ABC1183                
CDK9- Cyclin T1, IC50: 321 nM
                  99.19%
XL413                              
Cdc7, IC50: 3.4 nM
   
AT7519 TFA
Cdk1/cyclin B, IC50: 210 nM
cdk2/cyclin A, IC50: 47 nM
 
Cdk4/cyclin D1, IC50: 100 nM
CDK5/p35, IC50: 13 nM
cdk6/cyclin D3, IC50: 170 nM
CDK7/Cyclin H/MAT1, IC50: 2400 nM
 
CDK9/Cyclin T, IC50: 10 nM
                  98.53%
PHA-767491
CDK1, IC50: 250 nM
CDK2, IC50: 240 nM
   
CDK5, IC50: 460 nM
     
CDK9, IC50: 34 nM
                 
Palbociclib dihydrochloride      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                       
Palbociclib orotate      
Cdk4/cyclin D3, IC50: 9 nM
Cdk4/cyclin D1, IC50: 11 nM
 
Cdk6/cyclin D2, IC50: 16 nM
                       
CDK1-IN-5
CDK1, IC50: 42.19 nM
CDK2, IC50: 188.71 nM
   
CDK5, IC50: 354.15 nM
                         
Cimpuciclib      
CDK4, IC50: 0.49 nM
 
CDK6, IC50: 9.56 nM
                       
CDK1-IN-3
CDK1, IC50: 36.8 nM
CDK2, IC50: 305.17 nM
   
CDK5, IC50: 369.37 nM
                         
OTS964                  
CDK11B, Kd: 40 nM
               
ZLMT-12  
CDK2, IC50: 0.011 μM
           
CDK9, IC50: 0.002 μM
                 
CDK7-IN-2 hydrochloride hydrate            
CDK7
                     
Samuraciclib
CDK1, IC50: 1.8 μM
CDK2/cycE1, IC50: 578 nM
 
CDK4, IC50: 49 μM
CDK5, IC50: 9.4 μM
CDK6, IC50: 34 μM
CDK7/CycH/MAT1, IC50: 41 nM
 
CDK9, IC50: 1.2 μM
                 
CDK4/6-IN-3
CDK1, Ki: 110 nM
   
CDK4, Ki: 0.3 nM
 
CDK6, Ki: 2.2 nM
                       
FN-1501-propionic acid  
CDK2
           
CDK9
                 
CDK9-IN-9  
CDK2, IC50: 155 nM
           
CDK9, IC50: 1.8 nM
                 
CDK7-IN-11            
CDK7, IC50: 4.2 nM
                     
CDK2-IN-22  
CDK2, IC50: 64.42 nM
                               
HDAC1/2 and CDK2-IN-1  
CDK2, IC50: 0.80 nM
                               
Riviciclib
CDK1-Cyclin B, IC50: 0.079 μM
cdk2-cyclin A, IC50: 0.224 μM
cdk2-cyclin E, IC50: 2.540 μM
 
cdk4-cyclin D1, IC50: 0.063 μM
 
cdk6-cyclin D3, IC50: 0.396 μM
   
CDK9- Cyclin T1, IC50: 0.020 μM
CDK9-cyclin H, IC50: 2.900 μM
                 
CDK6/9-IN-1          
CDK6, IC50: 40.5 nM
   
CDK9, IC50: 39.5 nM
                 
Senexin A hydrochloride              
CDK8, IC50: 280 nM
CDK8, Kd: 0.83 μM
           
CDK19, Kd: 0.31 μM
     
Amantadine sulfate  
CDK2
                               
BS-181 dihydrochloride  
CDK2, IC50: 880 nM
   
CDK5, IC50: 3000 nM
 
CDK7, IC50: 21 nM
 
CDK9, IC50: 4200 nM
                 
CDK7-IN-6            
CDK7, IC50: ≤100 nM
                     
CDK7-IN-16            
CDK7, IC50: 1~10 nM
                     
CDK8-IN-6              
CDK8, Kd: 13 nM
                   
Haspin-IN-2                                
CLK1, IC50: 445 nM
 
CDK4/6-IN-18      
CDK4
 
CDK6
                       
(S)-LY3177833                              
Cdc7
   
CKI-7                              
Cdc7
   
CDK4/6-IN-12      
CDK4, IC50: 592.3 nM
 
CDK6, IC50: 3090 nM
                       
CDK2-IN-12  
CDK2, IC50: 11.6 μM
           
CDK9, IC50: >12.5 μM
                 
CDK7-IN-10            
CDK7, IC50: <100 nM
                     
HDAC1/CDK7-IN-1            
CDK7, IC50: 893 nM
                     
CDK4/6-IN-7      
CDK4, IC50: 1.58 nM
 
CDK6, IC50: 4.09 nM
                       
Multi-kinase-IN-4  
CDK2, IC50: 2.09 μM
                               
Cdc7-IN-15                              
Cdc7
   
PT-262  
CDK2
                                99.21%
Aloisine A
CDK1/cyclinB, IC50: 0.15 μM
CDK2/cyclinA, IC50: 0.12 μM
CDK2/cyclinE, IC50: 0.4 μM
   
CDK5/p35, IC50: 0.16 μM
                         
CDK2/4/6-IN-2  
CDK2
 
CDK4
 
CDK6
                       
CDK9-IN-28                
CDK9/cyclinT1
                 
CLK1/4-IN-1                                
CLK1, IC50: 9.7 nM
CLK4, IC50: 6.6 nM
 
Carbonic anhydrase inhibitor 14  
CDK2, IC50: 20.3 μM
                               
CDK1-IN-1
CDK1/cycB, IC50: 161.2 nM
                                 
Wogonin (Standard)              
CDK8
                   
CDK9-IN-11                
CDK9
                 
CDK2/4/6-IN-1  
CDK2, IC50: 2.5 nM
 
CDK4, IC50: 23.7 nM
 
CDK6, IC50: 44.3 nM
                       
PROTAC CDK9 degrader-2                
CDK9, IC50: 17 μM (MCF-7 cells)
                 
CDK1/Cyc B-IN-1
CDK1-Cyclin B, IC50: 97 nM
                                 
CDK9-IN-24                
CDK9
                 
HEMTAC CDK4/6 degrader 1      
CDK4
 
CDK6
                       
XL413 hydrochloride                              
Cdc7, IC50: 3.4 nM
   
CDK2-IN-8  
CDK2, IC50: 1.74 μM
                               
CDK5-IN-2  
CDK2/CycA, IC50: 23 nM
   
Cdk5/p25, IC50: 0.2 nM
                         
Cdc7-IN-14                              
Cdc7, IC50: <1 nM
   
CDK2-IN-9  
CDK2, IC50: 0.63 μM
                               
Cdc7-IN-13                              
Cdc7, IC50: <1 nM
   
Fascaplysin      
CDK4
                           
CDK5-IN-1        
CDK5
                         
CDK9-IN-19                
CDK9/cyclinT1, IC50: 2 nM
                 
CDK9-IN-22  
cdk2/cyclin A, IC50: 876.2 nM
           
CDK9/cyclinT1, IC50: 10.4 nM
                 
SHR5428
CDK1, IC50: >100 μM
CDK2, IC50: 8.99 μM
 
CDK4, IC50: 3.87 μM
 
CDK6, IC50: 5.89 μM
CDK7, IC50: 0.005 μM
 
CDK9, IC50: 8.30 μM
 
CDK12, IC50: 1.11 μM
             
CDK2-IN-20  
CDK2/cyclinE, IC50: 0.219 μM
                               
CDK12-IN-6  
CDK2/cyclinE, IC50: >20 μM
           
CDK9/cyclinT1, IC50: >20 μM
 
CDK12, IC50: 1.19 μM
             
YKL-1-116            
CDK7
                     
CDK4/6-IN-14
CDK1, IC50: >10000 nM
CDK2, IC50: 1045 nM
 
CDK4, IC50: 10 nM
 
CDK6, IC50: 16 nM
CDK7, IC50: 2595 nM
 
CDK9, IC50: 2664 nM
                 
CDK8-IN-12              
CDK8, Ki: 14 nM
                   
ZDLD20      
CDK4/CycD3, IC50: 6.51  μM
                            99.84%
IIIM-290  
CDK2/A, IC50: 90 nM
           
CDK9/T1, IC50: 94 nM
                 
CDK/HDAC-IN-2
CDK1, IC50: 8.63 nM
CDK2, IC50: 0.30 μM
 
CDK4, IC50: >1000 nM
 
CDK6, IC50: >1000 nM
CDK7, IC50: >1000 nM
                     
CDK8-IN-10              
CDK8, IC50: 8.25 nM
                   
ZLHQ-5f  
CDK2/CycA2, IC50: 0.145 μM
                               
CDK4/6-IN-16      
CDK4, IC50: 13 nM
                           
KDM1/CDK1-IN-1
CDK1, IC50: 0.078 ± 2. μM
                                 
CDK2-IN-18  
CDK2/cyclinE, IC50: 8 nM
 
Cdk4/cyclin D1, IC50: 46 nM
                           
CDK6/PIM1-IN-1
CDK1/cyclinB, IC50: >10 μM
CDK2/cyclinA, IC50: 2.274 μM
CDK3/Cyclin E, IC50: >10 μM
Cdk4/cyclin D1, IC50: 3.6 nM
Cdk5/p25, IC50: >10 μM
CDK6/cyclinD1, IC50: 39 nM
CDK7/Cyclin H/MNAT1, IC50: 393 nM
 
CDK9/cyclinT1, IC50: 440 nM
 
CDK12/Cyclin K, IC50: >10 μM
CDK13/Cyclin K, IC50: >10 μM
           
CDK7-IN-20
CDK1, IC50: 3375 nM
CDK2, IC50: 823 nM
CDK3, IC50: 1837 nM
 
CDK5, IC50: >10,000 nM
CDK6, IC50: 950 nM
CDK7, IC50: 4 nM
 
CDK9, IC50: 526 nM
 
CDK12, IC50: >10,000 nM
             
CDK8-IN-7              
CDK8, Kd: 3.5 nM
                   
CLK1/2-IN-1                                
CLK1, IC50: 16 nM
CLK2, IC50: 45 nM
 
CDK2-IN-7  
CDK2/cyclinE, IC50: 50 nM
                               
SHP2/CDK4-IN-1      
CDK4, IC50: 18.2 ± 1.3 nM
                           
CDK8-IN-5              
CDK8, IC50: 72 nM
                   
Anticancer agent 30  
CDK2
                               
KB-0742                
CDK9/cyclinT1, IC50: 6 nM
                 
Cdc7-IN-18                              
Cdc7, IC50: 1.29 nM
   
Cdc7-IN-12                              
Cdc7, IC50: <1 nM
   
SZ-015268            
CDK7, IC50: 23.56 nM
                     
PROTAC CDK9 degrader-6                
CDK942, DC50: 0.03 μM
CDK955, DC50: 0.05 μM
                 
PROTAC CDK9/CycT1 Degrader-2                
CDK9, IC50: 45 nM
                 
CLK1/2-IN-3                                
CLK1, IC50: 1.1 nM
CLK2, IC50: 2.1 nM
 
FLT3/ITD-IN-4                          
CDK16/Cyclin Y, EC50: 1768 nM
       
PSTAIR                              
CDC28
   
GSK-3 inhibitor 4  
CDK2, IC50: 0.47 μM
   
CDK5, IC50: 0.68 μM
                         
3-Methylthienyl-carbonyl-JNJ-7706621
CDK1/cyclinB, IC50: 6.4 nM
CDK2/cyclinA, IC50: 2 nM
 
CDK4, IC50: 0.11 μM
                           
CDK7-IN-8            
CDK7, IC50: 54.29 nM
                     
CDK4/6-IN-9          
CDK6/cyclinD1, IC50: 905 nM
                       
Cdc7-IN-19                              
Cdc7, IC50: 1.49 nM
   
CDK7-IN-4            
CDK7
                     
Manzamine A        
CDK5, IC50: 1.5 μM
                         
ZLWT-37  
CDK2, IC50: 0.054 μM
           
CDK9, IC50: 0.002 μM
                 
CDK2-IN-26  
CDK2
                               
ZDLD13      
CDK4/CycD3, IC50: 0.38 μM
                           
CDK1/2/4-IN-1
CDK1, IC50: 1.47
CDK2, IC50: 0.78
 
CDK4, IC50: 0.87
                           
CDK-IN-12      
CDK4, IC50: <20 nM
 
CDK6, IC50: <20 nM
                       
Anticancer agent 29
CDK1/cyclinB1, IC50: 0.127 μM
CDK2/cyclinE, IC50: 0.054 μM
 
CDK4, IC50: 0.129 μM
 
CDK6, IC50: 0.396 μM
                       
CDK7/9-IN-1            
CDK7, IC50: 5.74-65.6 nM
 
CDK9, IC50: 2.14 μM
                 
Ryuvidine      
CDK4, IC50: 6.0 μM
                           
CDK19 Probe 1                            
CDK19, IC50: 1.01 μM
     
CDK12-IN-4  
CDK2/cyclinE, IC50: >20 μM
           
CDK9/cyclinT1, IC50: >20 μM
 
CDK12, IC50: 0.641 μM
             
Ulecaciclib  
cdk2/cyclin A, Ki: 0.62 μM
 
Cdk4/cyclin D1, Ki: 0.2 nM
 
cdk6/cyclin D3, Ki: 3 nM
cdk7-cyclin H, Ki: 0.63 μM
                     
CDK2-IN-28  
CDK2, Ki: 1 nM ([1])
   
CDK5, Ki: 15.8 nM ([1])
 
CDK7, Ki: 54.7 nM ([1])
 
CDK9, Ki: 12.8 nM ([1])
                 
Abemaciclib metabolite M18      
CDK4
 
CDK6
                       
PROTAC CDK9 degrader-8                
CDK9, IC50: 0.01 μM
                 
CDK9-IN-32                
CDK9
                 
CDK4/6-IN-8      
CDK4, IC50: 5.01 nM
 
CDK6, IC50: 3.97 nM
                       
Indirubin-3'-monoxime-5-sulphonic acid
CDK1, IC50: 5 nM
     
CDK5, IC50: 7 nM
                         
Multi-kinase-IN-6  
CDK2, IC50: 0.71 μM
                               
CLZX-205                
CDK9, IC50: 2.9 nM
                 
CDK9-IN-23                
CDK9, IC50: <20 nM
                 
EGFR-IN-45  
CDK2, IC50: 1.6 μM
                               
CDK-IN-9  
CDK2/E, IC50: 4 nM
   
Cdk5/p25, IC50: 39 nM
     
CDK9/T1, IC50: 20 nM
 
CDK12/K, IC50: 64 nM
CDK13/K, IC50: 22 nM
           
Aloisine RP106
Cdk1/cyclin B, IC50: 0.7 μM
     
Cdk5/p25, IC50: 1.5 μM
                         
Indirubin-5-sulfonate
Cdk1/cyclin B, IC50: 55 nM
cdk2/cyclin A, IC50: 35 nM
CDK2/cyclinE, IC50: 150 nM
 
Cdk4/cyclin D1, IC50: 300 nM
CDK5/p35, IC50: 65 nM
                         
PROTAC CDK9 degrader-5                
CDK942, DC50: 0.10 μM
CDK955, DC50: 0.14 μM
                 
CDK2-IN-15  
CDK2, IC50: 2.9 μM
                               
CDK7-IN-7            
CDK7, IC50: <50 nM
                     
CDK7-IN-5            
CDK7, IC50: <100 nM
                     
CDK9-IN-14                
CDK9, IC50: 6.92 nM
                 
Haspin-IN-1                                
CLK1, IC50: 221 nM
 
CDK4/6-IN-10      
CDK4, IC50: 22 nM
 
CDK6/cyclinD1, IC50: 10 nM
                       
CDK2-IN-14-d3  
CDK2
                               
CDK7-IN-27  
CDK2, IC50: 19.4 nM
       
CDK7, IC50: 3 nM
                     
FLT3/CDK4-IN-1      
CDK4, IC50: 7 nM
                           
CDK9-IN-12                
CDK9/cyclinT1, IC50: 5.41 nM
                 
CDK1-IN-4
CDK1, IC50: 44.52 nM
CDK2, IC50: 621.93 nM
   
CDK5, IC50: 135.22 nM
                         
CDK2-IN-27
CDK1/cyclinB1, IC50: >10-20 nM nM
CDK2/cyclin E1, IC50: <10 nM
                               
(R)-DRF053 dihydrochloride
CDK1/cyclinB1, IC50: 220 nM
     
Cdk5/p25, IC50: 80 nM
                         
JA397                        
CDK14/Cyclin Y, EC50: 27.1 nM
CDK16/Cyclin Y, EC50: 39.0 nM