1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

Toll-like Receptor (TLR)

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. TLRs recognize highly conserved structural motifs known as pathogen-associated microbial patterns (PAMPs), which are exclusively expressed by microbial pathogens.

Toll-like Receptor (TLR) Related Products (23):

Cat. No. Product Name Effect Purity
  • HY-11109
    TAK-242 Inhibitor 99.95%
    TAK-242 is a potent TLR4 signaling inhibitor, selectively inhibits the TLR4-mediated production of cytokines and NO.
  • HY-17589
    Chloroquine diphosphate Inhibitor 99.94%
    Chloroquine (diphosphate) is an antimalarial drug and autophagy/lysosome inhibitor, inhibiting Toll-like receptor (TLR) signalling.
  • HY-13740
    Resiquimod Agonist 99.85%
    Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the levels of cytokines such as TNF-α, IL-6 and IFN-α.
  • HY-15601
    GS-9620 Agonist 98.78%
    GS-9620 is a potent and selective orally active agonist of Toll-Like Receptor (TLR)7.
  • HY-B0180
    Imiquimod Agonist 99.57%
    Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
  • HY-103697A
    Gardiquimod trifluoroacetate Agonist 99.28%
    Gardiquimod trifluoroacetate is a specific TLR7 agonist which can also inhibit HIV-1 reverse transcriptase.
  • HY-100442
    Paquinimod 98.38%
    Paquinimod is a S100A9 inhibitor, which prevents S100A9 binding to TLR-4.
  • HY-103698A
    TLR7/8 agonist 1 dihydrochloride Agonist 98.02%
    TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline.
  • HY-13773
    Motolimod Agonist 98.83%
    Motolimod is a selective Toll-like receptor (TLR) 8 agonist, with EC50 of about 100 nM.
  • HY-100461
    C29 Inhibitor >98.0%
    C29 is a potential TLR2 inhibitor.
  • HY-B1370
    Hydroxychloroquine sulfate Inhibitor 99.99%
    Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling.
  • HY-N0201
    Atractylenolide I Antagonist 99.08%
    Atractylenolide I is a natural compound extracted from largehead atractylodes rhizome; induce apoptosis and bring about cytotoxicity of human promyeloleukemic HL-60 cells; TLR4-antagonizing agent.
  • HY-N0741
    Leonurine Inhibitor 99.45%
    Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect.
  • HY-108471
    CU CPT 22 Inhibitor >99.0%
    CU CPT 22 is a toll-like receptor 1 and 2 (TLR1/2) inhibitor with an IC50 of 0.58 µM.
  • HY-N0741A
    Leonurine hydrochloride Inhibitor 99.32%
    Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
  • HY-10018
    Toll-like receptor modulator Modulator 99.40%
    A Toll-like receptor modulator.
  • HY-N0795
    Procyanidin B1 Antagonist 99.92%
    Procyanidin B1 , inhibits infection by vesicular stomatitis virus and HCV pseudotype virus in Huh-7 cells, with IC50 of 29μM and 15μM, respectively.
  • HY-103483
    MD2-IN-1 Inhibitor 99.85%
    MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189  μM for the recombinant human MD2 (rhMD2).
  • HY-103039
    TLR7-agonist-1 Agonist 98.82%
    TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.
  • HY-U00435
    Neoseptin 3 Agonist
    Neoseptin 3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist with an EC50 of 18.5 μM.
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