Hydroxychloroquine sulfate (Synonyms: HCQ sulfate)

Cat. No.: HY-B1370 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro.

For research use only. We do not sell to patients.

Hydroxychloroquine sulfate Chemical Structure

CAS No. : 747-36-4

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in Water	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Based on 47 publication(s) in Google Scholar

Other Forms of Hydroxychloroquine sulfate:

Hydroxychloroquine In-stock
(S)-Hydroxychloroquine Get quote
(R)-Hydroxychloroquine Get quote
Hydroxychloroquine sulfate (Standard) Get quote
Hydroxychloroquine-d₄ sulfate Get quote

47 Publications Citing Use of MCE Hydroxychloroquine sulfate

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TLR7

Plasmodium

TLR9

In Vitro

Hydroxychloroquine sulfate is a synthetic antimalarial drug derived from 4-aminoquinoline; it has been used for several decades for the treatment of some rheumatic diseases such as rheumatoid arthritis (RA)^[1]. Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

433.95

Appearance

Solid

Formula

C₁₈H₂₈ClN₃O₅S

CAS No.

747-36-4

SMILES

CCN(CCO)CCCC(NC1=CC=NC2=CC(Cl)=CC=C12)C.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 110 mg/mL (253.49 mM; Need ultrasonic and warming)

DMF : 1.4 mg/mL (3.23 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3044 mL	11.5221 mL	23.0441 mL
5 mM	0.4609 mL	2.3044 mL	4.6088 mL
10 mM	0.2304 mL	1.1522 mL	2.3044 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS
Solubility: 100 mg/mL (230.44 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (246 KB) HNMR (188 KB) LCMS (404 KB)

Handling Instructions (2659 KB)

References

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [Content Brief]

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [Content Brief]

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237. [Content Brief]

Animal Administration
^[2]

MRL/lpr mice are dosed orally five times a week with 20 or 60 mg/kg E6446 or 60 mg/kg Hydroxychloroquine sulfate beginning at 5 weeks of age. CB 4564 is administered at 50 mg/kg i.p. every 10 days. A serum sample is taken immediately before the beginning of treatment to monitor changes in autoreactive antibodies. Subsequently, serum samples are collected approximately monthly and analyzed for anti-dsDNA by ELISA after 1:500 dilution. Body weights and urine samples are taken at the same interval, and proteinuria is assessed. Anti-nuclear antibodies (ANA) are assessed using commercially available HEp2 slide kits, with serum diluted to 1:100 in kit buffer. ANA scores are read blinded^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [Content Brief]

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [Content Brief]

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237. [Content Brief]

Hydroxychloroquine sulfate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Hydroxychloroquine747-36-4HCQParasiteToll-like Receptor (TLR)SARS-CoVAutophagySARS coronavirusInhibitorinhibitorinhibit

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Hydroxychloroquine sulfate (Synonyms: HCQ sulfate)

Customer Review

Other Forms of Hydroxychloroquine sulfate:

Hydroxychloroquine sulfate Related Antibodies

47 Publications Citing Use of MCE Hydroxychloroquine sulfate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

View All Toll-like Receptor (TLR) Isoform Specific Products:

Biological Activity

Protocol

Purity & Documentation

References

Customer Review

Hydroxychloroquine sulfate Related Antibodies

Hydroxychloroquine sulfate Related Classifications

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Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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