Signaling Pathway

CRISPR/Cas9

CRISPR/Cas9

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CRISPR/Cas9 Inhibitors & Modulators (6)

Product Name Catalog No. Brief Description
4-Hydroxytamoxifen

HY-16950

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer.

Brefeldin A

HY-16592

Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus; induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus.

KU-57788

HY-11006

KU-57788(NU7441) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 value of  are 14 nM; 1700, 5000, >100000 and >100000 nM for  mTOR, PI 3K, ATM and ATR respectively; also is a modest inhibitor of BRD4 and BRDT with IC50s of 1 and 3.5 uM respectively.

RS-1

HY-19793

RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51.

SCR7

HY-12742

SCR7 is a molecule that inhibits joining of DSBs in cell-free repair system; inhibits NHEJ(nonhomologous end-joining) in a Ligase IV-dependent manner within cells, and activates the intrinsic apoptotic pathway.

Zidovudine

HY-17413

Zidovudine (Azidothymidine, AZT) is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS infection.