9A1P9
Based on 1 Customer Validation
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 2760467-57-8
- Formula: C27H58NO4P
- Molecular Weight:491.73
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
9A1P9 shows higher membrane-disruptive activity at the acidic endosomal compartment compared to that of neutral pH[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Preparation of iPLNP[2]:
9A1P9 : Fluc mRNA = 11,622 : 1 (molar ratio).
9A1P9 : MDOA (DODAP or 5A2-SC8) : cholesterol : DMG-PEG2000 = 25 : 30 : 30 : 1 (molar ratio).
9A1P9 : DOPE : cholesterol : DMG-PEG2000 = 55 : 30 : 45 : 0.2 (molar ratio).
9A1P9 : DDAB (or DOTAP) : cholesterol : DMG-PEG2000 = 60 : 30 : 40 : 0.4 (molar ratio).
The weight ratio of 9A1P9 to RNA is 18:1 (w/w).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:female C57BL/6 mice (6-8 weeks)[2]
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Dosage:9A1P9:mRNA weight ratio was fixed at 18:1
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Administration:Intravenous injection (i.v.)
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Result:9A1P9 demonstrates universal applicability to synergistically function with zwitterionic, ionizable cationic and permanently cationic helper lipids to formulate multi-component LNPs for selective organ targeting (SORT) to mediate exclusive transfection in spleen, liver or lungs in mice.
Chemical Information
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CAS No. 2760467-57-8
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Appearance Liquid
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Molecular Weight 491.73
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Formula C27H58NO4P
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Color Colorless to light yellow
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SMILES
O=P(OCCN(CCCCCCCC)CCCCCCCC)(OCCCCCCCCC)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (265 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Godbout K, et al. Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy. Pharmaceutics. 2022 Oct 7;14(10):2129. [Content Brief]
[2]. Liu S, et al. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing. Nat Mater. 2021 May;20(5):701-710. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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