1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Mineralocorticoid Receptor

Mineralocorticoid Receptor

Mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily and is essential for controlling sodium transport in epithelial tissues such as the kidney and colon.

Mineralocorticoid receptor (MR) is a nuclear receptor (NR) that is critical for controlling sodium and potassium transport in epithelial cells, most notably in the kidney and colon. It also plays important roles in non-epithelial tissues, such as cardiac myocytes, blood vessels, the hippocampus and adipose tissue. The MR is capable of binding multiple classes of steroids with high affinity, including the mineralocorticoids, aldosterone and deoxycorticosterone, the glucocorticoids (GR), cortisol (in humans) or corticosterone (in rodents), and progesterone (PR). While aldosterone is considered the primary physiological MR ligand in humans, in some tissues cortisol may be the primary ligand for MR, whereas PR behaves as a predominant antagonist.

Mineralocorticoid Receptor Related Products (14):

Cat. No. Product Name Effect Purity
  • HY-B0251
    Eplerenone Antagonist 99.68%
    Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.
  • HY-16276
    Osilodrostat Inhibitor 99.04%
    Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively.
  • HY-B1438
    Canrenone Antagonist 99.16%
    Canrenone (Aldadiene; SC9376; SC14266) is an aldosterone antagonist extensively used as a diuretic agent.
  • HY-B1203A
    Fludrocortisone acetate Agonist 99.45%
    Fludrocortisone acetate (9α-Fludrocortisone acetate) is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body.
  • HY-100471
    Esaxerenone Antagonist 99.65%
    Esaxerenone is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.
  • HY-109017
    Vamorolone Antagonist 98.74%
    Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
  • HY-117965
    Miricorilant Antagonist
    Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders.
  • HY-111372
    Finerenone Antagonist
    Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.
  • HY-B1472
    Deoxycorticosterone acetate Agonist 98.45%
    Deoxycorticosterone acetate is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
  • HY-109002
    Apararenone Antagonist 98.80%
    Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.
  • HY-B1203
    Fludrocortisone Agonist
    Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.
  • HY-12738
    PF-3882845 Antagonist
    PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM.
  • HY-113151
    18-Oxocortisol Antagonist
    18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.
  • HY-U00200
    Dicirenone Antagonist
    Dicirenone (SC26304) inhibits the effects of Aldosterone on urinary K+:Na+ ratios and the binding of [3H]Aldosterone to renal cytoplasmic and nuclear receptors.
Isoform Specific Products

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