1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor
    Endogenous Metabolite
  3. Canrenone

Canrenone (Synonyms: Aldadiene; SC9376)

Cat. No.: HY-B1438 Purity: 99.54%
Handling Instructions

Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

For research use only. We do not sell to patients.

Canrenone Chemical Structure

Canrenone Chemical Structure

CAS No. : 976-71-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner[1]. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

340.46

Formula

C₂₂H₂₈O₃

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (293.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9372 mL 14.6860 mL 29.3720 mL
5 mM 0.5874 mL 2.9372 mL 5.8744 mL
10 mM 0.2937 mL 1.4686 mL 2.9372 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (8.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (8.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (8.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[2]

Confluent Hepatic Stellate Cells (HSC) are incubated in SFIF medium for 24 hours and exposed to increasing concentrations of canrenone (1, 5, 10, 25 μM). Cell viability is evaluated by the trypan blue dye exclusion test at the end of a 24- to 48-hour incubation period[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Rats[3]

Canrenone (CAN) is given orally in two different doses (10.25, 20.5 mg/mL) to Male SPF Sprague-Dawley rats for 6 weeks. To determine the Na+, K+, fluid and aldosterone excretion the urine of the rats destined to be killed after 6 weeks is collected at weekly intervals[3]

.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

CanrenoneAldadiene SC9376SC9376SC 9376SC-9376Mineralocorticoid ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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Canrenone
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