1. Metabolic Enzyme/Protease
  2. Mineralocorticoid Receptor

Canrenone (Synonyms: Aldadiene; SC9376; SC14266)

Cat. No.: HY-B1438 Purity: 99.16%
Handling Instructions

Canrenone (Aldadiene; SC9376; SC14266) is an aldosterone antagonist extensively used as a diuretic agent.

For research use only. We do not sell to patients.

Canrenone Chemical Structure

Canrenone Chemical Structure

CAS No. : 976-71-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Canrenone (Aldadiene; SC9376; SC14266) is an aldosterone antagonist extensively used as a diuretic agent.

IC50 & Target

Target: Aldosterone[1]

In Vitro

Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner[1]. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor[2].

In Vivo

Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone[3].

Clinical Trial
References
Cell Assay
[2]

Confluent Hepatic Stellate Cells (HSC) are incubated in SFIF medium for 24 hours and exposed to increasing concentrations of canrenone (1, 5, 10, 25 μM). Cell viability is evaluated by the trypan blue dye exclusion test at the end of a 24- to 48-hour incubation period[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Rats[3]

Canrenone (CAN) is given orally in two different doses (10.25, 20.5 mg/mL) to Male SPF Sprague-Dawley rats for 6 weeks. To determine the Na+, K+, fluid and aldosterone excretion the urine of the rats destined to be killed after 6 weeks is collected at weekly intervals[3]

.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

340.46

Formula

C₂₂H₂₈O₃

CAS No.

976-71-6

SMILES

C[[email protected]@]12[[email protected]]3(CCC(O3)=O)CC[[email protected]@]1([H])[[email protected]]4([H])C=CC5=CC(CC[[email protected]]5(C)[[email protected]@]4([H])CC2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Canrenone
Cat. No.:
HY-B1438
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Canrenone

Cat. No.: HY-B1438