Flt-3/CD135
Flt-3, or CD135, is a class III receptor tyrosine kinase whose ligand, FLT3 ligand, is a key regulator of early hematopoiesis. The receptor is expressed on multipotent progenitors and early myeloid and lymphoid precursors, where FLT3L engagement supports their expansion and survival. FLT3 is also the most frequently mutated gene in acute myeloid leukemia: internal tandem duplications in the juxtamembrane domain or activating point mutations in the activation loop, most commonly D835, drive constitutive signaling and adverse prognosis. This has made FLT3 a validated oncology target, and the inhibitors midostaurin, gilteritinib and quizartinib are approved or advanced in AML therapy.
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Flt-3/CD135 Recombinant Proteins (11)
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Inhibitors & Agonists (343)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
