PDK1
PDK1, encoded by the PDPK1 gene, is the master upstream activator of the AGC kinase group, not to be confused with pyruvate dehydrogenase kinase of the same abbreviation. Its kinase domain is joined to a C-terminal PH domain that binds PIP3, recruiting it to the plasma membrane upon PI3K activation. Its substrates are other kinases: PDK1 phosphorylates the activation-loop threonine of AKT, SGK, PKC isoforms, RSK, and roughly twenty other AGC members. Substrate docking uses a hydrophobic PIF pocket that engages the phosphorylated hydrophobic motif of client kinases, integrating membrane recruitment with motif priming. Sitting atop the PI3K cascade, PDK1 dosage strongly shapes cancer phenotypes, and it is genetically validated as a target in PTEN-deficient tumors.
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PDK1 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
