ICAM-1/CD54
ICAM-1, the CD54 antigen, is an inducible transmembrane glycoprotein of the immunoglobulin superfamily expressed on endothelial and epithelial cells, leukocytes and fibroblasts. Five extracellular Ig-like domains bind the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), providing the adhesive surface that captures circulating leukocytes and drives their transendothelial migration during inflammation. Basal expression is low but strongly upregulated by TNF-alpha, IL-1 and LPS through NF-κB-dependent transcription. ICAM-1 also serves as a receptor for rhinovirus and for Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 in plasma reflects endothelial activation and is studied as a biomarker in atherosclerosis, sepsis and transplant rejection.
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ICAM-1/CD54 Recombinant Proteins (9)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
