1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. ICAM-1/CD54 Immunoglobulin-like Cell Adhesion Molecules
  5. Intercellular Adhesion Molecule 1 (ICAM-1)
  6. ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His)

ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His)

Cat. No.: HY-P74873
Handling Instructions

The ICAM-1/CD54 protein is a ligand of the leukocyte adhesion protein LFA-1 and is critical for leukocyte transendothelial migration. Its involvement activates ARHGEF26/SGEF and RHOG, coordinating endothelial apical cup assembly. ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His) is 453 a.a., with molecular weight of 70-115 kDa.

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Description

The ICAM-1/CD54 protein is a ligand of the leukocyte adhesion protein LFA-1 and is critical for leukocyte transendothelial migration. Its involvement activates ARHGEF26/SGEF and RHOG, coordinating endothelial apical cup assembly. ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ICAM-1/CD54 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His) is 453 a.a., with molecular weight of 70-115 kDa.

Background

ICAM-1/CD54 Protein, as a ligand for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2), plays a crucial role in leukocyte trans-endothelial migration. Engagement of ICAM-1 during this process promotes the assembly of endothelial apical cups through the activation of ARHGEF26/SGEF and RHOG, revealing its involvement in orchestrating dynamic cellular events (By similarity). ICAM-1 also forms homodimers and interacts with MUC1, fostering cell aggregation in epithelial cells. Furthermore, its interaction with ARHGEF26/SGEF underscores its participation in signaling pathways that regulate cellular dynamics. On the T cell side, ICAM-1 interacts with CD81, CD247, and CD9 at immunological synapses between antigen-presenting cells and T cells, emphasizing its pivotal role in immune cell interactions during the formation of immunological synapses. The multifaceted interactions of ICAM-1 highlight its significance in mediating diverse cellular processes and facilitating cell-cell communication.

Species

Rhesus Macaque

Source

HEK293

Tag

C-6*His

Accession

Q5NKV6 (Q28-E480)

Gene ID

712280  [NCBI]

Molecular Construction
N-term
ICAM-1 (Q28-E480)
Accession # Q5NKV6
6*His
C-term
Synonyms
Intercellular Adhesion Molecule 1; ICAM-1; CD54
Molecular Weight

70-115 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ICAM-1/CD54 Protein, Rhesus Macaque (HEK293, His)
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HY-P74873
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