1. Neuronal Signaling
  2. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.86%
    Fluoxetine hydrochloride is an antidepressant and a selective serotonin reuptake inhibitor.
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist 99.79%
    Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively.
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.84%
    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine (maleate) (DU-23000 (maleate)) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
  • HY-18332C
    DOV-216,303 Free Base Inhibitor 98.47%
    DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats.
  • HY-N0173
    Cinchonidine Inhibitor >98.0%
    Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities.
  • HY-111419
    DSP-1053 Inhibitor
    DSP-1053 is a potent Serotonin Transporter (SERT) (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonistic activity.
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.89%
    Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM in vitro.
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
  • HY-B1287
    Citalopram hydrobromide Inhibitor >99.0%
    Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 99.76%
    Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
  • HY-B0457
    Clomipramine hydrochloride Inhibitor 99.72%
    Clomipramine HCl is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.75%
    Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
  • HY-15414
    Vortioxetine Inhibitor 98.81%
    Vortioxetine is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
  • HY-14258A
    Escitalopram oxalate Inhibitor >98.0%
    Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
  • HY-15414A
    Vortioxetine hydrobromide Inhibitor 99.54%
    Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.94%
    Vilazodone Hydrochloride is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
  • HY-B0725
    Doxepin Hydrochloride Inhibitor 99.41%
    Doxepin HCl is a tricyclic antidepressant that is marketed worldwide.
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