1. Signaling Pathways
  2. Neuronal Signaling
  3. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter Related Products (47):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.84%
    Fluoxetine hydrochloride is an antidepressant and a selective serotonin reuptake inhibitor.
  • HY-42110
    Deschloroclozapine Antagonist 99.79%
    Deschloroclozapine is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively.
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.
  • HY-B1272
    Desipramine hydrochloride Inhibitor 99.68%
    Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine (maleate) (DU-23000 (maleate)) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
  • HY-15414S
    Vortioxetine D8 Inhibitor
    Vortioxetine D8 is a deuterium labeled Vortioxetine. Vortioxetine is an inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
  • HY-B0161AS
    Duloxetine D3 hydrochloride Inhibitor
    Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
  • HY-B0457S
    Clomipramine D3 hydrochloride Inhibitor
    Clomipramine D3 hydrochloride is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.93%
    Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM in vitro.
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.90%
    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-14258A
    Escitalopram oxalate Inhibitor 99.98%
    Escitalopram oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
  • HY-B1287
    Citalopram hydrobromide Inhibitor >99.0%
    Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
  • HY-B0457
    Clomipramine hydrochloride Inhibitor 99.72%
    Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
  • HY-B0168A
    Milnacipran hydrochloride Inhibitor 99.87%
    Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 99.76%
    Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
  • HY-15414
    Vortioxetine Inhibitor 98.81%
    Vortioxetine is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
  • HY-15414A
    Vortioxetine hydrobromide Inhibitor 99.94%
    Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.95%
    Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.87%
    Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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