Cat. No.: HY-B0492

Paroxetine hydrochloride

(Synonyms: BRL29060 hydrochloride; BRL29060A)

19 Cited Publications

Customer Review

Based on 19 publication(s) in Google Scholar

Paroxetine (BRL29060) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine hydrochloride inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine hydrochloride is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine hydrochloride is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 78246-49-8
Formula: C₁₉H₂₁ClFNO₃
Molecular Weight:365.83

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Paroxetine hydrochloride Chemical Structure

CAS No.: 78246-49-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (19)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

CYP2D6

5-HT₂ Receptor

All Cytochrome P450 Isoforms :

All 5-HT Receptor Isoforms :

All NO Synthase Isoforms :

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	220 μM Compound: 4a	Inhibition of recombinant full-length human N-terminal GST tagged PKCalpha expressed in Baculovirus infected Sf9 insect cells using KRREILSRRPSYR as substrate incubated for 30 mins by ADP-Glo assay Inhibition of recombinant full-length human N-terminal GST tagged PKCalpha expressed in Baculovirus infected Sf9 insect cells using KRREILSRRPSYR as substrate incubated for 30 mins by ADP-Glo assay	[PMID: 27362616]
Spermatozoa	ED₅₀	0.008 % Compound: Paroxetine.HCl	Spermicidal activity against human spermatozoa Spermicidal activity against human spermatozoa	[PMID: 16464584]

In Vitro

Paroxetine hydrochloride potently and selectively inhibits serotonin reuptake in rat brain synaptosomes, with a K_i of 1.1 nmol/L, and shows much weaker activity against norepinephrine and dopamine reuptake^[1].
Paroxetine hydrochloride has no significant affinity for most tested neurotransmitter receptors in rat brain tissue, only showing weak binding to muscarinic cholinergic receptors with a K_i of 89 nmol/L^[1].
Paroxetine hydrochloride (76 nM) exhibits high affinity for the muscarinic M1 receptor, resulting in greater anticholinergic effects than other SSRIs^[2].
Paroxetine hydrochloride exhibits estrogenic activity in an in vitro assay that identifies chemicals disrupting aromatase and estrogen balance in humans, which may promote estrogen-sensitive breast tumor growth^[2].
Paroxetine hydrochloride (10-20 μM; 6-24 h) differentially modulates LPS-induced cytokine production in Raw264.7 mouse macrophages, potently inhibiting IL-6 production and enhancing TNFα production at 10 μM and 20 μM concentrations after 6 and 24 hours of incubation^[3].
Paroxetine hydrochloride (10-20 μM; 6-24 h) differentially modulates LPS-induced cytokine production in thioglycollate-elicited primary mouse peritoneal macrophages, potently inhibiting IL-6 production and enhancing TNFα production at 10 μM and 20 μM concentrations after 6 and 24 hours of incubation^[3].
Paroxetine hydrochloride (20 μM; 24 h) inhibits LPS-induced IL-6 production independent of 5-HT2/5-HT7 receptors and enhances LPS-induced TNFα production via 5-HT2/5-HT7 receptors in Raw264.7 mouse macrophages after 24 hours of incubation^[3].
Paroxetine hydrochloride (20 μM) modulates LPS-induced IL-6 and TNFα production in Raw264.7 mouse macrophages independently of GRK2, as its inhibitory effect on IL-6 and enhancing effect on TNFα are retained in GRK2-knockdown cells^[3].
Paroxetine hydrochloride (10-30 μM, 72 h) reduces the viability of MCF-7 cells in a time- and dose-dependent manner^[4].
Paroxetine hydrochloride (10-30 μM, 1-12 h) induces mitochondrial-mediated apoptosis in MCF-7, increasing ROS generation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[3]

Cell Line:

Raw264.7 mouse macrophages
Concentration:

10 μM; 20 μM
Incubation Time:

6 h; 24 h
Result:

Reduced LPS-induced IL-6 production to ~75% of LPS-only levels at 6 hours with 10 μM.
Reduced LPS-induced IL-6 production to ~50% of LPS-only levels at 6 hours with 20 μM.
Reduced LPS-induced IL-6 production to ~80% of LPS-only levels at 24 hours with 10 μM.
Reduced LPS-induced IL-6 production to ~60% of LPS-only levels at 24 hours with 20 μM.
Increased LPS-induced TNFα production to ~155% of LPS-only levels at 6 hours with 10 μM.
Increased LPS-induced TNFα production to ~195% of LPS-only levels at 6 hours with 20 μM.
Increased LPS-induced TNFα production to ~120% of LPS-only levels at 24 hours with 10 μM.
Increased LPS-induced TNFα production to ~145% of LPS-only levels at 24 hours with 20 μM.

ELISA Assay^[3]

Cell Line:

Raw264.7 mouse macrophages pretreated with 5-HT2/5-HT7 receptor antagonist LY215840
Concentration:

20 μM
Incubation Time:

24 h
Result:

Reduced LPS-induced IL-6 production to ~45% of LPS-only levels.
Increased LPS-induced TNFα production to ~180% of LPS-only levels.
Co-treatment with LY215840 (10 nM, 100 nM, 1 μM) further reduced IL-6 levels to below ~20% of LPS-only levels.
Co-treatment with LY215840 (10 nM, 100 nM, 1 μM) reversed TNFα enhancement, reducing levels to ~80%, ~40%, and ~40% of LPS-only levels, respectively (for 100 nM and 1 μM LY215840).

In Vivo

Paroxetine (8-32 mg/kg) hydrochloride produces a dose-dependent anti-immobility effect in the mouse forced swim test and also exhibits noradrenergic activity^[1].
Paroxetine hydrochloride exerts no significant dopaminergic, sedative, or ethanol-potentiating effects in healthy rodent models^[1].
Paroxetine hydrochloride produces extremely mild cardiovascular effects in healthy cats, rabbits, and dogs compared with tricyclic antidepressants, and exhibits weak quinidine-like activity only at serotonin reuptake-blocking doses^[1].
Combination of Paroxetine hydrochloride with monoamine oxidase inhibitors (MAOIs) or serotonin precursors induces serotonin syndrome in rats^[1].
Paroxetine hydrochloride modulates the hypothalamic-pituitary-adrenal axis and prolactin-related endocrine activity in healthy rats^[1].
Acute treatment with Paroxetine hydrochloride (5 mg/kg) increases extracellular serotonin levels in the brain of healthy rats^[1].
Paroxetine hydrochloride antagonizes apomorphine-induced hypothermia in rats, indicating that it exhibits noradrenergic activity at high doses^[1].
Combination treatment with Paroxetine hydrochloride (for 3 consecutive weeks) and Pravastatin (HY-B0165) increases the blood glucose level of prediabetic, insulin-resistant mice from 128 mg/dl to 193 mg/dl^[2].
Paroxetine (10 mg/kg, i.p., once a day for 14 days) hydrochloride reduces neurogenic pain in rats both before and after sciatic nerve injury^[5].
Paroxetine (0.3-10 mg/kg, orally, single dose) hydrochloride has anti-anxiety and antidepressant effects in rats, increasing social interaction time^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats^[6]
Dosage:

0.3, 1, 3, 10 mg/kg; single dose
Administration:

p.o.
Result:

Reduced the synthesis rate of serotonin and increased the social time of rats, but had no effect on motor activity. The motor activity of animals taking the drug for a long time was slightly lower than that of animals taking the drug for a short time.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 78246-49-8
Appearance Solid
Molecular Weight 365.83
Formula C₁₉H₂₁ClFNO₃
Color White to off-white
SMILES

FC1=CC=C([C@H]2[C@H](COC3=CC=C(OCO4)C4=C3)CNCC2)C=C1.Cl
Synonyms

BRL29060 hydrochloride; BRL29060A
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Publications (19)

All In Vivo Efficacy StudyCell Proliferation/Viability AssayRT-PCRWBBio/Physico-chemical AssayIFHistological Imaging/Staining2D/3D Cell Culture and Differentiation

Sort by:

Journal Impact Factor

Cell

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. [Abstract]

2021 Apr 15;184(8):2167-2182.e22. PMID: 33811809
NPJ Digit Med

Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients. [Abstract]

2025 Nov 17;8(1):663. PMID: 41249389

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663. [Abstract]

Heat map display of cell viabilities of A549 (Left) and H1299 (Right) cells after incubation with different concentrations of anti-ED compounds (Paroxetine (10–200 μg/mL), et al.) for 48 h. The results showed that paroxetine did not significantly promote tumor cell proliferation; instead, it exerted a mild inhibitory effect on cell growth at higher concentrations.
Autophagy

Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death. [Abstract]

2025 May;21(5):934-956. PMID: 39663580
Cell Rep Med

5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation. [Abstract]

2026 Jan 20;7(1):102537. PMID: 41494533

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102537. [Abstract]

IC₅₀ of Paroxetine hydrochloride (1-12.5 μM) in the indicated cell lines.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102537. [Abstract]

Colony formation assays in the indicated cells treated with DMSO or gradient doses of Paroxetine hydrochloride (0.5-7.5 μM).

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102537. [Abstract]

A375 xenografts were established and treated with vehicle or Paroxetine hydrochloride (25 mg/kg daily intraperitoneally [i.p.]) for 14 days. Tumors in each group were individually recorded every 2 days. n = 8 tumors per group.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102537. [Abstract]

5-HT levels in A375 cells treated with DMSO or the indicated Paroxetine hydrochloride treatment for 24 h.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2026 Jan 20;7(1):102537. [Abstract]

A375^DTR xenografts were established and treated with vehicle or PH (25 mg/kg daily i.p. injection) for 15 days. The tumors in each group were individually recorded every 3 days. n = 8 tumors per group.
Cell Rep

LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia. [Abstract]

2025 Apr 2;44(4):115489. PMID: 40178973

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 2;44(4):115489. [Abstract]

Paroxetine (5 mg/kg; i.p.; once daily for 2–3 weeks) alleviated pain and depression-like symptoms in mice subjected to chronic restraint stress (CRS).
J Chem Inf Model

Development of Machine Learning Models and the Discovery of a New Antiviral Compound against Yellow Fever Virus. [Abstract]

2021 Aug 23;61(8):3804-3813. PMID: 34286575
Drug Des Devel Ther

2026 Jan 27;20:1-16.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2026 Jan 27;20:1-16.

CCK-8 assay was performed with different concentrations of Paroxetine (0.0625-10 μM) in BMMs for 1 day and 3 days.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2026 Jan 27;20:1-16.

Assessment of mRNA expression levels of osteoclastogenesis-associated marker genes after administration with Paroxetine (0.0625-2.5 μM) by RT-qPCR, including NFATc1, c-fos, RANK, TRAP, Cathepsin K, and MMP9. he results showed that Paroxetine inhibited the expression of NFATc1, c-fos, RANK, TRAP, Cathepsin K, and MMP9 genes in a concentration-dependent manner.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2026 Jan 27;20:1-16.

Assessment of protein expression levels of NFATc1, c-fos, Cathepsin K and MMP9 after administration with Paroxetine (0.0625-2.5 μM; pretreatment 2 h before stimulation+ 3 d after stimulation) by Western blot. The results demonstrated that, following RANKL stimulation, the protein expression levels of NFATc1, c-fos, CTSK, and MMP9 significantly increased. However, Paroxetine reduced the expression levels of these proteins in osteoclasts in a concentration-dependent manner.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2026 Jan 27;20:1-16.

Representative fluorescence images of P65 nuclear translocation following RANKL stimulation without or with Paroxetine (PA) (pretreatment 6 h). The results showed that RANKL stimulation led to a significant increase in the mean nuclear fluorescence intensity of p65, whereas Paroxetine treatment attenuated this effect.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2026 Jan 27;20:1-16.

Histopathology photographs of femoral samples after HE-stained sections. The results revealed that the trabecular bone in the distal femoral region of mice in the LPS group became sparse and thin. In contrast, Paroxetine (PA, 20 mg/kg; i.p.; once daily for 10 days) effectively alleviated bone loss, as evidenced by the intact and well-ordered arrangement of trabeculae in mice of this group.

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2026 Jan 27;20:1-16.

Representative TRAP staining images of RANKL-induced osteoclasts treated with Paroxetine (2.5 μM) on specified days. The results showed that the addition of Paroxetine during the early stage of differentiation (days 1-3) significantly inhibited osteoclast formation. In contrast, when bone marrow-derived macrophages (BMMs) were exposed to Paroxetine from days 3-5 or days 5-7, the number of osteoclasts was also reduced, but the inhibitory effect was less pronounced compared to the early-stage (days 1–3) exposure.
Drug Des Devel Ther

Paroxetine as a Therapeutic Agent in Inflammatory Osteolysis: Mechanistic Insights and Efficacy. [Abstract]

2026 Jan 27:20:561725. PMID: 41868178
Int J Mol Sci

Lidocaine Modulates Cytokine Production and Reprograms the Tumor Immune Microenvironment to Enhance Anti-Tumor Immune Responses in Gastric Cancer. [Abstract]

2025 Mar 31;26(7):3236. PMID: 40244064
Pharmaceuticals (Basel)

Comparative Pharmacological Profiling of Psychotherapeutic Drugs Reveals a Functional Taxonomy Based on Direct Inhibition of Smooth Muscle Excitability. [Abstract]

2026 Apr 21;19(4):645. PMID: 42075900
Front Pharmacol

N-demethylsinomenine metabolite and its prototype sinomenine activate mast cells via MRGPRX2 and aggravate anaphylaxis. [Abstract]

2024 Jul 31:15:1389761. PMID: 39144634
Front Pharmacol

Machine Learning for Discovery of New ADORA Modulators. [Abstract]

2022 Jun 22:13:920643. PMID: 35814244
ACS Omega

Involvement of Integrated Stress Response in Drug-Induced Secondary Dystonia. [Abstract]

2025 Oct 17;10(42):50208-50217. PMID: 41179162
Sci Rep

Paroxetine suppresses 27-hydroxycholesterol-induced responses in THP-1 human monocytic cells by regulating the AKT/mTORC1 pathway. [Abstract]

2025 Oct 21;15(1):36797. PMID: 41120475
Brain Res

Serum miR-221-3p as a new potential biomarker for depressed mood in perioperative patients. [Abstract]

2019 Oct 1:1720:146296. PMID: 31211948

Paroxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Res. 2019 Oct 1:1720:146296. [Abstract]

Protein levels of IFNα and IRF2(B) are detected in HA1800 Cells at 6 h, 12 h and 24 h after paroxetine (10μM) treatment by RT-qPCR and western blot respectively.
Biochem Biophys Res Commun

Screening of potential drugs for the treatment of diabetic kidney disease using single-cell transcriptome sequencing and connectivity map data. [Abstract]

2024 Jun 13:725:150263. PMID: 38905995
J Mol Cell Cardiol Plus

The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension. [Abstract]

2024 Mar 26:8:100072. PMID: 39802918
University of South Carolina

2025.
Patent

US20250127769A1.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (273.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 5 mg/mL (13.67 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7335 mL

13.6676 mL

27.3351 mL

5 mM

0.5467 mL

2.7335 mL

5.4670 mL

10 mM

0.2734 mL

1.3668 mL

2.7335 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 2.03 mg/mL (5.55 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bourin M, et al. Paroxetine: a review[J]. CNS drug reviews, 2001, 7(1): 25-47.

[2]. Nevels RM, et al. Paroxetine-The Antidepressant from Hell? Probably Not, But Caution Required. Psychopharmacology bulletin. 2016 Mar 01;46(1):77-104. [Content Brief]

[3]. Durairaj H, et al. Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages. International immunopharmacology. 2015 Apr;25(2):485-92. [Content Brief]

[4]. Young-Woo Cho, et al. Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca2+-and p38 MAP Kinase-Dependent ROS Generation. Cancers (Basel). 2019 Jan 9;11(1):64. [Content Brief]

[5]. Malek Zarei, et al. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J. 2014;18(2):94-100. [Content Brief]

[6]. S Lightowler, et al. Anxiolytic-like effect of paroxetine in a rat social interaction test. Pharmacol Biochem Behav. 1994 Oct;49(2):281-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.7335 mL	13.6676 mL	27.3351 mL	68.3378 mL
	5 mM	0.5467 mL	2.7335 mL	5.4670 mL	13.6676 mL
	10 mM	0.2734 mL	1.3668 mL	2.7335 mL	6.8338 mL
DMSO	15 mM	0.1822 mL	0.9112 mL	1.8223 mL	4.5559 mL
	20 mM	0.1367 mL	0.6834 mL	1.3668 mL	3.4169 mL
	25 mM	0.1093 mL	0.5467 mL	1.0934 mL	2.7335 mL
	30 mM	0.0911 mL	0.4556 mL	0.9112 mL	2.2779 mL
	40 mM	0.0683 mL	0.3417 mL	0.6834 mL	1.7084 mL
	50 mM	0.0547 mL	0.2734 mL	0.5467 mL	1.3668 mL
	60 mM	0.0456 mL	0.2278 mL	0.4556 mL	1.1390 mL
	80 mM	0.0342 mL	0.1708 mL	0.3417 mL	0.8542 mL
	100 mM	0.0273 mL	0.1367 mL	0.2734 mL	0.6834 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Paroxetine hydrochloride

19 Cited Publications

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Paroxetine hydrochloride

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Publications Citing Use of MedChemExpress (MCE) Paroxetine hydrochloride

All Cytochrome P450 Isoforms

All 5-HT Receptor Isoforms

All NO Synthase Isoforms

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

Publications (19)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Paroxetine hydrochloride Related Classifications

HY-B0492 Related Classifications