2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Serotonin Transporter
  4. Vilazodone Hydrochloride

Vilazodone Hydrochloride  (Synonyms: EMD 68843 Hydrochloride; SB659746A Hydrochloride)

Cat. No.: HY-14261 Assay: 100.70%
COA
SDS
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Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.

For research use only. We do not sell to patients.

CAS No. : 163521-08-2

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10 mM * 1 mL in DMSO
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Vilazodone Hydrochloride:

Vilazodone Hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Vilazodone Hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 22:e17877.  [Abstract]

    Vilazodone(25 mg/kg, i.p.)-treated mice exhibited pronounced pancreatic edema and increased pancreas‐to‐body weight ratios.

    Vilazodone Hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 22:e17877.  [Abstract]

    H&E staining indicated that Vilazodone (25 mg/kg, i.p.) significantly exacerbated pancreatic injury in L-arginine-treated AP mice compared to controls.

    Vilazodone Hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 22:e17877.  [Abstract]

    IHC confirmed aggravated local and systemic inflammation, evidenced by increased levels of IL‐1β and TNF-α in Vilazodone (25 mg/kg, i.p.)-treated mice with AP.

    Vilazodone Hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Jan 22:e17877.  [Abstract]

    ELISA confirmed aggravated local and systemic inflammation, evidenced by increased levels of IL‐1β and TNF‐α in Vilazodone (25 mg/kg, i.p.)‐treated mice with AP.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.

    IC50 & Target[1]

    sPLA2

     

    5-HT1A Receptor

     

    In Vivo

    Administration of 5-HT1A receptor agonists produce a characteristic behavioral syndrome that includes changes in posture, hind limb reduction, head weaving, tremors, forepaw treading, and straub tail. In the rat ultrasonic vocalizations test, stress-induced vocalizations are inhibited by Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (55 mg/kg po) at 120 and 210 min post dose. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) (20-40 mg/kg ip), administered acutely or prophylactically (1 week prior to behavioral testing), attenuated stress induces potentiated startle but has no effect on stress potentiated anxiety response in the elevated plus maze. Interestingly, a lower dose of 10 mg/kg of Vilazodone Hydrochloride (EMD 68843 Hydrochloride) has the opposite effect in the startle response, indicating a somewhat unexplained bidirectional effect, and all doses produce a potentiation of the startle-induced stress response possibly suggestive of an anxiogenic-like response[1]. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) also represents another option for the treatment of MDD[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    477.99

    Formula

    C26H28ClN5O2
    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    NC(C1=CC2=C(C=CC(N3CCN(CCCCC4=CNC5=CC=C(C=C54)C#N)CC3)=C2)O1)=O.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (52.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0921 mL 10.4605 mL 20.9209 mL
    5 mM 0.4184 mL 2.0921 mL 4.1842 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.23 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (5.23 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 100.70%

    SDS (418 KB)

    COA (247 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.0921 mL 10.4605 mL 20.9209 mL 52.3024 mL
    5 mM 0.4184 mL 2.0921 mL 4.1842 mL 10.4605 mL
    10 mM 0.2092 mL 1.0460 mL 2.0921 mL 5.2302 mL
    15 mM 0.1395 mL 0.6974 mL 1.3947 mL 3.4868 mL
    20 mM 0.1046 mL 0.5230 mL 1.0460 mL 2.6151 mL
    25 mM 0.0837 mL 0.4184 mL 0.8368 mL 2.0921 mL
    30 mM 0.0697 mL 0.3487 mL 0.6974 mL 1.7434 mL
    40 mM 0.0523 mL 0.2615 mL 0.5230 mL 1.3076 mL
    50 mM 0.0418 mL 0.2092 mL 0.4184 mL 1.0460 mL
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    Vilazodone Hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vilazodone163521-08-2EMD 68843SB659746AEMD68843EMD-688435-HT ReceptorSerotonin TransporterSerotonin Receptor5-hydroxytryptamine Receptor5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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