Product Name |
5-HT6 Receptor |
5-HT1 Receptor |
5-HT2 Receptor |
5-HT3 Receptor |
5-HT5 Receptor |
5-HT7 Receptor |
5-HT4 Receptor |
5-HT6 Receptor Selectivity |
Purity |
WAY-181187 |
5-HT6 Receptor, Ki: 2.2 nM
5-HT6 Receptor, EC50: 6.6 nM
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Selective Agonist
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98.05% |
Idalopirdine Hydrochloride |
5-HT6 Receptor, Ki: 0.83 nM
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Selective Antagonist
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99.83% |
Intepirdine |
5-HT6 Receptor, pKi: 9.63
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Selective Antagonist
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98.92% |
SB 271046 Hydrochloride |
5-HT6 Receptor, pKi: 8.92-9.02
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5-HT1D Receptor, pKi: 6.55
5-HT1A Receptor, pKi: 6.35
5-HT1B Receptor, pKi: 6.05
5-HT1F Receptor, pKi: 5.95
5-HT1E Receptor, pKi: <4.99
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5-HT2A Receptor, pKi: 5.62
5-HT2B Receptor, pKi: 5.41
Human 5-HT2C Receptor, pKi: 5.73
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5-HT7 Receptor, pKi: 5.39
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5-HT4 Receptor, pKi: 5.27
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Selective Antagonist
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98.64% |
NPS ALX Compound 4a |
5-HT6 Receptor, IC50: 7.2 nM
5-HT6 Receptor, Ki: 0.2 nM
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Selective Antagonist
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≥99.0% |
Masupirdine mesylate |
5-HT6 Receptor, Ki: 2.04 nM
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Selective Antagonist
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PRX-07034 hydrochloride |
5-HT6 Receptor, Ki: 4-8 nM
5-HT6 Receptor, IC50: 19 nM
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5-HT1A Receptor, Ki: 420 nM
5-HT1B Receptor, Ki: 260 nM
5-HT1D Receptor, Ki: 2.8 μM
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5-HT2A Receptor, IC50: 2.5 μM
5-HT2B Receptor, IC50: 2.5 μM
5-HT2C Receptor, IC50: 3.7 μM
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Selective Antagonist
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ST1936 oxalate |
5-HT6 Receptor, Ki: 13 nM
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5-HT2B Receptor, Ki: 245 nM
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Human 5-HT7 Receptor , Ki: 168 nM
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Selective Agonist
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EMDT oxalate |
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Selective Agonist
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SGS518 oxalate |
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Selective Antagonist
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NPS ALX Compound 4a dihydrochloride |
5-HT6 Receptor, IC50: 7.2 nM
5-HT6 Receptor, Ki: 0.2 nM
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Selective Antagonist
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Masupirdine free base |
5-HT6 Receptor, Ki: 2.04 nM
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Selective Antagonist
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Idalopirdine |
5-HT6 Receptor, Ki: 0.83 nM
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Selective Antagonist
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5HT6-ligand-1 |
5-HT6 Receptor, Ki: 1.43 nM
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Selective
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Olanzapine |
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5-HT2A Receptor, Ki: 4 nM
5-HT2C Receptor, Ki: 11 nM
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5-HT3 Receptor, Ki: 57 nM
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Pan Antagonist
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99.89% |
AVN-492 |
5-HT6 Receptor, Ki: 91 pM
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Pan Antagonist
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99.49% |
Methiothepin mesylate |
5-HT6 Receptor, pKd: 8.74
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5-HT1A Receptor, pKd: 7.10
5-HT1B Receptor, pKd: 7.28
5-HT1C Receptor, pKd: 7.56
5-HT1D Receptor, pKd: 6.99
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5-HT2A Receptor, pKi: 8.50
5-HT2B Receptor, pKi: 8.68
5-HT2C Receptor, pKi: 8.35
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5-HT5A Receptor, pKd: 7.0
5-HT5B Receptor, pKd: 7.8
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5-HT7 Receptor, pKd: 8.99
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Pan Antagonist
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≥98.0% |
Iloperidone |
Rat 5-HT6 Receptor, Ki: 42.7 μM
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Rat 5-HT1A Receptor, Ki: 168 nM
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Rat 5-HT2 Receptor, Ki: 3.1 nM
Human 5-HT2A Receptor, Ki: 5.6 nM
Human 5-HT2C Receptor, Ki: 42.8 nM
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Rat 5-HT7 Receptor, Ki: 21.6 nM
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Pan Antagonist
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99.64% |
Asenapine |
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5-HT1A Receptor, pKi: 8.6
5-HT1B Receptor, pKi: 8.4
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5-HT2A Receptor, pKi: 10.2
5-HT2C Receptor, pKi: 10.5
5-HT2B Receptor, pKi: 9.8
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Pan Antagonist
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98.81% |
Blonanserin |
5-HT6 Receptor, Ki: 11.7 nM
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5-HT2A Receptor, Ki: 0.812 nM
5-HT2C Receptor, Ki: 26.4 nM
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Pan Antagonist
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99.77% |
BRL 54443 |
5-HT6 Receptor, Ki: >10,000 nM
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5-HT1E Receptor, Ki: 1.1 nM
5-HT1F Receptor, Ki: 0.7 nM
5-HT1A Receptor, Ki: 63 nM
5-HT1B Receptor, Ki: 126 nM
5-HT1D Receptor, Ki: 63 nM
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5-HT2A Receptor, Ki: 1259 nM
5-HT2B Receptor, Ki: 100 nM
5-HT2C Receptor, Ki: 316 nM
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5-HT7 Receptor, Ki: >10,000 nM
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Pan Agonist
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99.39% |
Nuciferine |
5-HT6 Receptor, EC50: 700 nM
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5-HT1A Receptor, EC50: 3.2 μM
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5-HT2C Receptor, IC50: 131 nM
5-HT2A Receptor, IC50: 478 nM
5-HT2B Receptor, IC50: 1 μM
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5-HT7 Receptor, IC50: 150 nM
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Pan Modulator
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99.66% |
RS-127445 hydrochloride |
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5-HT2A Receptor, pKi: 6.3
5-HT2C Receptor, pKi: 6.4
5-HT2B Receptor, pKi: 9.5
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Pan Antagonist
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99.68% |
GSK163090 |
Human 5-HT6 Receptor, pKi: <5.3
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5-HT1A Receptor, pKi: 9.4
5-HT1B Receptor, pKi: 8.5
5-HT1D Receptor, pKi: 9.7
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5-HT2A Receptor, pKi: 6
5-HT2B Receptor, pKi: 6.3
5-HT2C Receptor, pKi: 5.8
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Human 5-HT7 Receptor , pKi: 6.8
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Pan Antagonist
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99.95% |
SB-399885 hydrochloride |
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Pan Antagonist
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99.54% |
SB 243213 dihydrochloride |
Human 5-HT6 Receptor, pKi: 6.5
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human 5-HT1A Receptor, pKi: <5.3
human 5-HT1B Receptor, pKi: 5.5
human 5-HT1D Receptor, pKi: 6.32
human 5-HT1E Receptor, pKi: <5.4
human 5-HT1F Receptor, pKi: 5.35
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Human 5-HT2C Receptor, pKi: 9.37
Human 5-HT2A Receptor, pKi: 7.01
human 5-HT2B Receptor, pKi: 7.2
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Human 5-HT7 Receptor , pKi: 5.64
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Pan Antagonist
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≥99.0% |
SB 243213 hydrochloride |
Human 5-HT6 Receptor, pKi: 6.5
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human 5-HT1A Receptor, pKi: <5.3
human 5-HT1B Receptor, pKi: 5.5
human 5-HT1D Receptor, pKi: 6.32
human 5-HT1E Receptor, pKi: <5.4
human 5-HT1F Receptor, pKi: 5.35
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Human 5-HT2C Receptor, pKi: 9.37
Human 5-HT2A Receptor, pKi: 7.01
human 5-HT2B Receptor, pKi: 7.2
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Human 5-HT7 Receptor , pKi: 5.64
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Pan Antagonist
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5-HT6/7 antagonist 1 |
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Pan Antagonist
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SB 243213 |
Human 5-HT6 Receptor, pKi: 6.5
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human 5-HT1A Receptor, pKi: <5.3
human 5-HT1B Receptor, pKi: 5.5
human 5-HT1D Receptor, pKi: 6.32
human 5-HT1E Receptor, pKi: <5.4
human 5-HT1F Receptor, pKi: 5.35
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Human 5-HT2C Receptor, pKi: 9.37
Human 5-HT2A Receptor, pKi: 7.01
human 5-HT2B Receptor, pKi: 7.2
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Human 5-HT7 Receptor , pKi: 5.64
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Pan Antagonist
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98.62% |
Ro 04-6790 |
Rat 5-HT6 Receptor, pKi: 7.26
Human 5-HT6 Receptor, pKi: 7.35
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Pan Antagonist
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BGC20-761 |
Human 5-HT6 Receptor, Ki: 20 nM
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Human 5-HT2A Receptor, Ki: 69 nM
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Pan Antagonist
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Sarizotan |
5-HT6 Receptor, IC50: 3300 nM (human)
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5-HT1D Receptor, IC50: 500 nM (calf)
5-HT1A Receptor, IC50: 6.5 nM (rat)
5-HT1A Receptor, IC50: 0.1 nM (human)
5-HT1B Receptor, IC50: 600 nM (rat)
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5-HT2A Receptor, IC50: 960 nM (rat, agonist site)
5-HT2A Receptor, IC50: 587 nM (human, antagonist site)
5-HT2C Receptor, IC50: 800 nM (pig)
5-HT2B Receptor, IC50: 108 nM (human)
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5-HT3 Receptor, IC50: 3500 nM (NG 108 cells)
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5-HT5A Receptor, IC50: 313 nM (human)
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5-HT7 Receptor, IC50: 10 nM (human)
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Pan Agonist
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Iloperidone hydrochloride |
Rat 5-HT6 Receptor, Ki: 42.7 nM
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Rat 5-HT1A Receptor, Ki: 168 nM
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Rat 5-HT2 Receptor, Ki: 3.1 nM
Human 5-HT2A Receptor, Ki: 5.6 nM
Human 5-HT2C Receptor, Ki: 42.8 nM
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Rat 5-HT7 Receptor, Ki: 21.6 nM
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Pan Antagonist
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