1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT6 Receptor Inhibitors

5-HT6 Receptor Inhibitors

5-HT1 Receptor

5-HT2 Receptor

5-HT3 Receptor

5-HT5 Receptor

5-HT6 Receptor

5-HT7 Receptor

5-HT Receptor

5-HT4 Receptor

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Sorry. There is currently no product that acts on isoform 5-HT6 Receptor together.

Please try each isoform separately.

5-HT6 Receptor Specific Agonists, Antagonists & Modulators
Product Name 5-HT6 Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT5 Receptor 5-HT7 Receptor 5-HT6 Receptor Selectivity Purity
Intepirdine
5-HT6 Receptor, pKi: 9.63
          Selective Antagonist 98.92%
Idalopirdine Hydrochloride
5-HT6 Receptor, Ki: 0.83 nM
          Selective Antagonist 99.17%
SB 271046 Hydrochloride
5-HT6 Receptor, pKi: 8.9
          Selective Antagonist 99.06%
WAY-181187
5-HT6 Receptor, Ki: 2.2 nM
5-HT6 Receptor, EC50: 6.6 nM
          Selective Agonist
NPS ALX Compound 4a
5-HT6 Receptor, IC50: 7.2 nM
5-HT6 Receptor, Ki: 0.2 nM
          Selective Antagonist >99.0%
Masupirdine mesylate
5-HT6 Receptor, Ki: 2.04 nM
          Selective Antagonist
PRX-07034 hydrochloride
5-HT6 Receptor, Ki: 4-8 nM
5-HT6 Receptor, IC50: 19 nM
5-HT1A Receptor, Ki: 420 nM
5-HT1B Receptor, Ki: 260 nM
5-HT1D Receptor, Ki: 2.8 μM
5-HT2A Receptor, IC50: 2.5 μM
5-HT2B Receptor, IC50: 2.5 μM
5-HT2C Receptor, IC50: 3.7 μM
      Selective Antagonist
ST1936 oxalate
5-HT6 Receptor, Ki: 13 nM
 
5-HT2B Receptor, Ki: 245 nM
   
Human 5-HT7 Receptor , Ki: 168 nM
Selective Agonist
EMDT oxalate
5-HT6 Receptor
          Selective Agonist
NPS ALX Compound 4a dihydrochloride
5-HT6 Receptor, IC50: 7.2 nM
5-HT6 Receptor, Ki: 0.2 nM
          Selective Antagonist
Masupirdine free base
5-HT6 Receptor, Ki: 2.04 nM
          Selective Antagonist
Idalopirdine
5-HT6 Receptor, Ki: 0.83 nM
          Selective Antagonist
5HT6-ligand-1
5-HT6 Receptor, Ki: 1.43 nM
          Selective
Olanzapine
5-HT6 Receptor, Ki: 5 nM
5-HT1 Receptor, Ki: 7 nM
5-HT2A Receptor, Ki: 4 nM
5-HT2C Receptor, Ki: 11 nM
5-HT3 Receptor, Ki: 57 nM
    Pan Antagonist 99.94%
Methiothepin mesylate
5-HT6 Receptor, pKd: 8.74
5-HT1A Receptor, pKd: 7.10
5-HT1B Receptor, pKd: 7.28
5-HT1C Receptor, pKd: 7.56
5-HT1D Receptor, pKd: 6.99
5-HT2A Receptor, pKi: 8.50
5-HT2B Receptor, pKi: 8.68
5-HT2C Receptor, pKi: 8.35
 
5-HT5A Receptor, pKd: 7.0
5-HT5B Receptor, pKd: 7.8
5-HT7 Receptor, pKd: 8.99
Pan Antagonist 99.32%
RS-127445 hydrochloride
5-HT6 Receptor, pKi: <6
 
5-HT2A Receptor, pKi: 6.3
5-HT2C Receptor, pKi: 6.4
5-HT2B Receptor, pKi: 9.5
5-HT3 Receptor, pKi: <6
5-HT5 Receptor, pKi: <6
  Pan Antagonist 99.68%
Nuciferine
5-HT6 Receptor, EC50: 700 nM
5-HT1A Receptor, EC50: 3.2 μM
5-HT2C Receptor, IC50: 131 nM
5-HT2A Receptor, IC50: 478 nM
5-HT2B Receptor, IC50: 1 μM
   
5-HT7 Receptor, IC50: 150 nM
Pan Modulator 99.66%
Asenapine
5-HT6 Receptor, pKi: 9.6
5-HT1A Receptor, pKi: 8.6
5-HT1B Receptor, pKi: 8.4
5-HT2A Receptor, pKi: 10.2
5-HT2B Receptor, pKi: 9.8
5-HT2C Receptor, pKi: 10.5
 
5-HT5 Receptor, pKi: 8.8
5-HT7 Receptor, pKi: 9.9
Pan Antagonist 98.81%
BRL 54443
5-HT6 Receptor, Ki: >10,000 nM
5-HT1E Receptor, Ki: 1.1 nM
5-HT1F Receptor, Ki: 0.7 nM
5-HT1A Receptor, Ki: 63 nM
5-HT1B Receptor, Ki: 126 nM
5-HT1D Receptor, Ki: 63 nM
5-HT2A Receptor, Ki: 1259 nM
5-HT2B Receptor, Ki: 100 nM
5-HT2C Receptor, Ki: 316 nM
   
5-HT7 Receptor, Ki: >10,000 nM
Pan Agonist 99.39%
Iloperidone
Rat 5-HT6 Receptor, Ki: 42.7 μM
Rat 5-HT1A, Ki: 168 nM
Rat 5-HT2 Receptor, Ki: 3.1 nM
Human 5-HT2A Receptor, Ki: 5.6 nM
Human 5-HT2C Receptor, Ki: 42.8 nM
   
Rat 5-HT7 Receptor, Ki: 21.6 nM
Pan Antagonist 99.64%
AVN-492
5-HT6 Receptor, Ki: 91 pM
          Pan Antagonist 99.49%
5-HT6/7 antagonist 1
5-HT6 Receptor
 
5-HT2A Receptor
   
5-HT7 Receptor
Pan Antagonist
Ro 04-6790
Rat 5-HT6 Receptor, pKi: 7.26
Human 5-HT6 Receptor, pKi: 7.35
          Pan Antagonist
SB-399885 hydrochloride
5-HT6 Receptor
          Pan Antagonist 98.93%
Sarizotan
5-HT6 Receptor, IC50: 3300 nM (human)
5-HT1D Receptor, IC50: 500 nM (calf)
5-HT1A Receptor, IC50: 6.5 nM (rat)
5-HT1A Receptor, IC50: 0.1 nM (human)
5-HT1B Receptor, IC50: 600 nM (rat)
5-HT2A Receptor, IC50: 960 nM (rat, agonist site)
5-HT2A Receptor, IC50: 587 nM (human, antagonist site)
5-HT2C Receptor, IC50: 800 nM (pig)
5-HT2B Receptor, IC50: 108 nM (human)
5-HT3 Receptor, IC50: 3500 nM (NG 108 cells)
5-HT5A Receptor, IC50: 313 nM (human)
5-HT7 Receptor, IC50: 10 nM (human)
Pan Agonist
Iloperidone hydrochloride
Rat 5-HT6 Receptor, Ki: 42.7 nM
Rat 5-HT1A, Ki: 168 nM
Rat 5-HT2 Receptor, Ki: 3.1 nM
Human 5-HT2A Receptor, Ki: 5.6 nM
Human 5-HT2C Receptor, Ki: 42.8 nM
   
Rat 5-HT7 Receptor, Ki: 21.6 nM
Pan Antagonist