5-HT₆ Receptor Inhibitors

5-HT₁ Receptor

5-HT₂ Receptor

5-HT₃ Receptor

5-HT₅ Receptor

5-HT₆ Receptor

5-HT₇ Receptor

5-HT Receptor

5-HT₄ Receptor

5-HT₆ Receptor Specific Agonists, Antagonists & Modulators

Product Name	5-HT₆ Receptor	5-HT₁ Receptor	5-HT₂ Receptor	5-HT₃ Receptor	5-HT₅ Receptor	5-HT₇ Receptor	5-HT₄ Receptor	5-HT₆ Receptor Selectivity	Purity
WAY-181187	5-HT₆ Receptor, Ki: 2.2 nM 5-HT₆ Receptor, EC₅₀: 6.6 nM							Selective Agonist	98.05%
Idalopirdine Hydrochloride	5-HT₆ Receptor, Ki: 0.83 nM							Selective Antagonist	99.83%
Intepirdine	5-HT₆ Receptor, pKi: 9.63							Selective Antagonist	98.92%
SB 271046 Hydrochloride	5-HT₆ Receptor, pKi: 8.92-9.02	5-HT_1D Receptor, pKi: 6.55 5-HT_1A Receptor, pKi: 6.35 5-HT_1B Receptor, pKi: 6.05 5-HT_1F Receptor, pKi: 5.95 5-HT_1E Receptor, pKi: <4.99	5-HT_2A Receptor, pKi: 5.62 5-HT_2B Receptor, pKi: 5.41 Human 5-HT_2C Receptor, pKi: 5.73			5-HT₇ Receptor, pKi: 5.39	5-HT₄ Receptor, pKi: 5.27	Selective Antagonist	98.64%
NPS ALX Compound 4a	5-HT₆ Receptor, IC₅₀: 7.2 nM 5-HT₆ Receptor, Ki: 0.2 nM							Selective Antagonist	≥99.0%
Masupirdine mesylate	5-HT₆ Receptor, Ki: 2.04 nM							Selective Antagonist
PRX-07034 hydrochloride	5-HT₆ Receptor, Ki: 4-8 nM 5-HT₆ Receptor, IC₅₀: 19 nM	5-HT_1A Receptor, Ki: 420 nM 5-HT_1B Receptor, Ki: 260 nM 5-HT_1D Receptor, Ki: 2.8 μM	5-HT_2A Receptor, IC₅₀: 2.5 μM 5-HT_2B Receptor, IC₅₀: 2.5 μM 5-HT_2C Receptor, IC₅₀: 3.7 μM					Selective Antagonist
ST1936 oxalate	5-HT₆ Receptor, Ki: 13 nM		5-HT_2B Receptor, Ki: 245 nM			Human 5-HT₇ Receptor , Ki: 168 nM		Selective Agonist
EMDT oxalate	5-HT₆ Receptor							Selective Agonist
SGS518 oxalate	5-HT₆ Receptor							Selective Antagonist
NPS ALX Compound 4a dihydrochloride	5-HT₆ Receptor, IC₅₀: 7.2 nM 5-HT₆ Receptor, Ki: 0.2 nM							Selective Antagonist
Masupirdine free base	5-HT₆ Receptor, Ki: 2.04 nM							Selective Antagonist
Idalopirdine	5-HT₆ Receptor, Ki: 0.83 nM							Selective Antagonist
5HT6-ligand-1	5-HT₆ Receptor, Ki: 1.43 nM							Selective
Olanzapine	5-HT₆ Receptor, Ki: 5 nM	5-HT₁ Receptor, Ki: 7 nM	5-HT_2A Receptor, Ki: 4 nM 5-HT_2C Receptor, Ki: 11 nM	5-HT₃ Receptor, Ki: 57 nM				Pan Antagonist	99.89%
AVN-492	5-HT₆ Receptor, Ki: 91 pM							Pan Antagonist	99.49%
Methiothepin mesylate	5-HT₆ Receptor, pKd: 8.74	5-HT_1A Receptor, pKd: 7.10 5-HT_1B Receptor, pKd: 7.28 5-HT_1C Receptor, pKd: 7.56 5-HT_1D Receptor, pKd: 6.99	5-HT_2A Receptor, pKi: 8.50 5-HT_2B Receptor, pKi: 8.68 5-HT_2C Receptor, pKi: 8.35		5-HT_5A Receptor, pKd: 7.0 5-HT_5B Receptor, pKd: 7.8	5-HT₇ Receptor, pKd: 8.99		Pan Antagonist	≥98.0%
Iloperidone	Rat 5-HT₆ Receptor, Ki: 42.7 μM	Rat 5-HT_1A Receptor, Ki: 168 nM	Rat 5-HT₂ Receptor, Ki: 3.1 nM Human 5-HT_2A Receptor, Ki: 5.6 nM Human 5-HT_2C Receptor, Ki: 42.8 nM			Rat 5-HT₇ Receptor, Ki: 21.6 nM		Pan Antagonist	99.64%
Asenapine	5-HT₆ Receptor, pKi: 9.6	5-HT_1A Receptor, pKi: 8.6 5-HT_1B Receptor, pKi: 8.4	5-HT_2A Receptor, pKi: 10.2 5-HT_2C Receptor, pKi: 10.5 5-HT_2B Receptor, pKi: 9.8		5-HT₅ Receptor, pKi: 8.8	5-HT₇ Receptor, pKi: 9.9		Pan Antagonist	98.81%
Blonanserin	5-HT₆ Receptor, Ki: 11.7 nM		5-HT_2A Receptor, Ki: 0.812 nM 5-HT_2C Receptor, Ki: 26.4 nM					Pan Antagonist	99.77%
BRL 54443	5-HT₆ Receptor, Ki: >10,000 nM	5-HT_1E Receptor, Ki: 1.1 nM 5-HT_1F Receptor, Ki: 0.7 nM 5-HT_1A Receptor, Ki: 63 nM 5-HT_1B Receptor, Ki: 126 nM 5-HT_1D Receptor, Ki: 63 nM	5-HT_2A Receptor, Ki: 1259 nM 5-HT_2B Receptor, Ki: 100 nM 5-HT_2C Receptor, Ki: 316 nM			5-HT₇ Receptor, Ki: >10,000 nM		Pan Agonist	99.39%
Nuciferine	5-HT₆ Receptor, EC₅₀: 700 nM	5-HT_1A Receptor, EC₅₀: 3.2 μM	5-HT_2C Receptor, IC₅₀: 131 nM 5-HT_2A Receptor, IC₅₀: 478 nM 5-HT_2B Receptor, IC₅₀: 1 μM			5-HT₇ Receptor, IC₅₀: 150 nM		Pan Modulator	99.66%
RS-127445 hydrochloride	5-HT₆ Receptor, pKi: <6		5-HT_2A Receptor, pKi: 6.3 5-HT_2C Receptor, pKi: 6.4 5-HT_2B Receptor, pKi: 9.5	5-HT₃ Receptor, pKi: <6	5-HT₅ Receptor, pKi: <6			Pan Antagonist	99.68%
GSK163090	Human 5-HT₆ Receptor, pKi: <5.3	5-HT_1A Receptor, pKi: 9.4 5-HT_1B Receptor, pKi: 8.5 5-HT_1D Receptor, pKi: 9.7	5-HT_2A Receptor, pKi: 6 5-HT_2B Receptor, pKi: 6.3 5-HT_2C Receptor, pKi: 5.8			Human 5-HT₇ Receptor , pKi: 6.8		Pan Antagonist	99.95%
SB-399885 hydrochloride	5-HT₆ Receptor							Pan Antagonist	99.54%
SB 243213 dihydrochloride	Human 5-HT₆ Receptor, pKi: 6.5	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₇ Receptor , pKi: 5.64		Pan Antagonist	≥99.0%
SB 243213 hydrochloride	Human 5-HT₆ Receptor, pKi: 6.5	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₇ Receptor , pKi: 5.64		Pan Antagonist
5-HT6/7 antagonist 1	5-HT₆ Receptor		5-HT_2A Receptor			5-HT₇ Receptor		Pan Antagonist
SB 243213	Human 5-HT₆ Receptor, pKi: 6.5	human 5-HT_1A Receptor, pKi: <5.3 human 5-HT_1B Receptor, pKi: 5.5 human 5-HT_1D Receptor, pKi: 6.32 human 5-HT_1E Receptor, pKi: <5.4 human 5-HT_1F Receptor, pKi: 5.35	Human 5-HT_2C Receptor, pKi: 9.37 Human 5-HT_2A Receptor, pKi: 7.01 human 5-HT_2B Receptor, pKi: 7.2			Human 5-HT₇ Receptor , pKi: 5.64		Pan Antagonist	98.62%
Ro 04-6790	Rat 5-HT₆ Receptor, pKi: 7.26 Human 5-HT₆ Receptor, pKi: 7.35							Pan Antagonist
BGC20-761	Human 5-HT₆ Receptor, Ki: 20 nM		Human 5-HT_2A Receptor, Ki: 69 nM					Pan Antagonist
Sarizotan	5-HT₆ Receptor, IC₅₀: 3300 nM (human)	5-HT_1D Receptor, IC₅₀: 500 nM (calf) 5-HT_1A Receptor, IC₅₀: 6.5 nM (rat) 5-HT_1A Receptor, IC₅₀: 0.1 nM (human) 5-HT_1B Receptor, IC₅₀: 600 nM (rat)	5-HT_2A Receptor, IC₅₀: 960 nM (rat, agonist site) 5-HT_2A Receptor, IC₅₀: 587 nM (human, antagonist site) 5-HT_2C Receptor, IC₅₀: 800 nM (pig) 5-HT_2B Receptor, IC₅₀: 108 nM (human)	5-HT₃ Receptor, IC₅₀: 3500 nM (NG 108 cells)	5-HT_5A Receptor, IC₅₀: 313 nM (human)	5-HT₇ Receptor, IC₅₀: 10 nM (human)		Pan Agonist
Iloperidone hydrochloride	Rat 5-HT₆ Receptor, Ki: 42.7 nM	Rat 5-HT_1A Receptor, Ki: 168 nM	Rat 5-HT₂ Receptor, Ki: 3.1 nM Human 5-HT_2A Receptor, Ki: 5.6 nM Human 5-HT_2C Receptor, Ki: 42.8 nM			Rat 5-HT₇ Receptor, Ki: 21.6 nM		Pan Antagonist

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5-HT6 Receptor Inhibitors

5-HT₆ Receptor Inhibitors