2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor
  5. 5-HT6 Receptor Isoform

5-HT6 Receptor

 

5-HT6 Receptor Related Products (49):

Cat. No. Product Name Effect Purity
  • HY-14539
    Clozapine
    		Modulator 99.99%
    Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia.
  • HY-14541
    Olanzapine
    		Antagonist 99.89%
    Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM).
  • HY-N0049
    Nuciferine
    		Modulator 99.46%
    Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
  • HY-A0077
    Perphenazine
    		Antagonist 99.72%
    Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively.
  • HY-107836
    Methiothepin mesylate
    		Antagonist 99.32%
    Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
  • HY-103130
    EMD386088
    		Agonist
    EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist.
  • HY-15419
    RS-127445 hydrochloride
    		Antagonist 99.58%
    RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5.
  • HY-103112B
    SB 243213
    		Antagonist 98.62%
    SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor.
  • HY-10121
    Asenapine
    		Antagonist 99.93%
    Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0).
  • HY-13575
    Blonanserin
    		Antagonist 98.73%
    Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist.
  • HY-14339
    Intepirdine
    		Antagonist 98.92%
    Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.
  • HY-17410
    Iloperidone
    		Antagonist 99.95%
    Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist.
  • HY-14338A
    Idalopirdine Hydrochloride
    		Antagonist 99.83%
    Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM.
  • HY-103099
    SB-399885 hydrochloride
    		Antagonist 99.54%
    SB-399885 hydrochloride is a 5-HT6 receptor antagonist.
  • HY-14336A
    SB 271046 Hydrochloride
    		Antagonist 98.64%
    SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively.
  • HY-14340
    WAY-181187
    		Agonist 98.05%
    WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM.
  • HY-100820
    Sarizotan
    		Agonist 98.74%
    Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist.
  • HY-13221
    BRL 54443
    		Agonist 99.89%
    BRL 54443 is a potent 5-HT1E/1F receptor agonist (Ki values are 1.1 nM and 0.7 nM respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors.
  • HY-14348
    GSK163090
    		Antagonist 99.77%
    GSK163090 is a potent, selective and orally active 5-HT1A/1B/1D receptor antagonist with pKi values of 9.4/8.5/9.7, respectively.
  • HY-14559
    PRX-07034 hydrochloride
    		Antagonist 98.09%
    PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM.