1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Intepirdine

Intepirdine (Synonyms: SB-742457; GSK-742457; RVT-101)

Cat. No.: HY-14339 Purity: 98.92%
Handling Instructions

Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.

For research use only. We do not sell to patients.

Intepirdine Chemical Structure

Intepirdine Chemical Structure

CAS No. : 607742-69-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
25 mg USD 410 In-stock
Estimated Time of Arrival: December 31
50 mg USD 690 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE Intepirdine

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Description

Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.

IC50 & Target

pKi: 9.63 (5-HT6 Receptor)[1].

In Vitro

Intepirdine (SB742457), a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. Intepirdine (SB742457) is generally safe and well tolerated and may be efficacious in Alzheimer disease.

Clinical Trial
Molecular Weight

353.44

Formula

C₁₉H₁₉N₃O₂S

CAS No.

607742-69-8

SMILES

O=S(C1=CC=CC=C1)(C2=CC(C=CC=C3N4CCNCC4)=C3N=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (141.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8293 mL 14.1467 mL 28.2933 mL
5 mM 0.5659 mL 2.8293 mL 5.6587 mL
10 mM 0.2829 mL 1.4147 mL 2.8293 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.92%

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KeyWords:

Intepirdine | SB-742457 | GSK-742457 | RVT-101 | SB742457 | SB 742457 | GSK742457 | GSK 742457 | RVT101 | RVT 101 | 5-HT Receptor | Serotonin Receptor | 5-hydroxytryptamine Receptor | Inhibitor | inhibitor | inhibit

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Product name:
Intepirdine
Cat. No.:
HY-14339
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