Notch-4
Notch-4 is the least characterized of the four human Notch receptors and is expressed predominantly in endothelial cells, with reported roles in angiogenesis and vascular patterning. As a typical Notch family member it is a type I transmembrane protein whose intracellular domain is released by ADAM and gamma-secretase cleavage after ligand binding, then enters the nucleus to modulate RBPJ-dependent transcription. In mice the orthologous locus int-3 was identified as a common integration site of mouse mammary tumor virus, and ectopic Notch-4 activation is oncogenic in mammary epithelium. Genetic variants near NOTCH4 have also been associated with schizophrenia susceptibility in genome-wide studies.
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Notch-4 Recombinant Proteins (2)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
