1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin >99.0%
    Cisplatin is a antineoplastic chemotherapy drug which works by cross-linking with DNA and causing DNA damage in cancer cells.
  • HY-13316
    Mitomycin C 99.45%
    Mitomycin C is an antitumor drug and antibiotic that shows extraordinary ability to inhibit DNA synthesis. Mitomycin C is a DNA cross-linking agent, which induces DNA damaging.
  • HY-17371
    Oxaliplatin 99.86%
    Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and causes cell death. Oxaliplatin time-dependently inhibits human melanoma cell lines C32 and G361 with IC50 values of 0.98 μM and 0.14 μM, respectively.
  • HY-17364
    Temozolomide 99.96%
    Temozolomide (NSC 362856; CCRG 81045) is an oral DNA alkylating agent used to treat some brain cancers.
  • HY-17420
    Cyclophosphamide >98.0%
    Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
  • HY-128612
    Methylnitronitrosoguanidine >98.0%
    Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
  • HY-128880
    (+)-CBI-CDPI1
    (+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI1 is an antibody drug conjugates (ADCs) toxin.
  • HY-128881
    (+)-CBI-CDPI2
    (+)-CBI-CDPI2 is an enhanced functional analog of CC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent. (+)-CBI-CDPI2 is an antibody drug conjugates (ADCs) toxin.
  • HY-13753
    Streptozocin 99.58%
    Streptozocin is a potent DNA-methylating antibiotic. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA.
  • HY-17393
    Carboplatin 99.93%
    Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
  • HY-17575
    Melphalan >98.0%
    Melphalan is an effective DNA alkylating agent, with potent antitumor activity.
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks.
  • HY-B0245
    Busulfan >98.0%
    Busulfan is a potent alkylator with selective immunosuppressive effect on bone marrow.
  • HY-17419
    Ifosfamide >98.0%
    Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
  • HY-17420A
    Cyclophosphamide hydrate >98.0%
    Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
  • HY-B0077
    Bendamustine hydrochloride >98.0%
    Bendamustine hydrochloride is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.
  • HY-13585
    Carmustine 99.85%
    Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
  • HY-13424
    RITA 99.57%
    RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
  • HY-13733
    Procarbazine Hydrochloride
    Procarbazine Hydrochloride is an alkylating agent, with anticancer activity.
  • HY-13669
    Lomustine 99.91%
    Lomustine (CCNU) is a DNA alkylating agent, with antitumor activity.
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