1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker Related Products (27):

Cat. No. Product Name Effect Purity
  • HY-17371
    Oxaliplatin >98.0%
    Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
  • HY-17364
    Temozolomide 98.52%
    Temozolomide is a DNA-methylating agent. Temozolomide is an alkylating cytostatic drug.
  • HY-13753
    Streptozocin 99.58%
    Streptozocin is a potent DNA-methylating agent, with IC50 values of 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells respectively.
  • HY-17420
    Cyclophosphamide >98.0%
    Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
  • HY-17393
    Carboplatin 98.25%
    Carboplatin is an antitumor agent, with DNA-binding activity, interfering with duplication of DNA.
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin is a potent DNA-damaging cytotoxic agent.
  • HY-B0245
    Busulfan >98.0%
    Busulfan is a potent alkylator, with chemotherapeutic activity.
  • HY-17420A
    Cyclophosphamide hydrate >98.0%
    Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
  • HY-14573
    SJG-136 >98.0%
    SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA; with potent antitumor activity.
  • HY-13585
    Carmustine 99.86%
    Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
  • HY-B0077
    Bendamustine hydrochloride >98.0%
    Bendamustine Hcl(SDX105; EP-3101) is a DNA-damaging agent with IC50 of 50 μM.
  • HY-13424
    RITA
    RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
  • HY-17574
    Thio-TEPA 98.54%
    Thio-TEPA is a DNA alkylating agent, with antitumor activity.
  • HY-17419
    Ifosfamide >98.0%
    Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
  • HY-16513
    VAL-083 >98.0%
    VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
  • HY-B0733
    Fotemustine
    Fotemustine is a DNA-alkylating agent, with antitumor activity.
  • HY-13733
    Procarbazine Hydrochloride
    Procarbazine Hydrochloride is an alkylating agent, with anticancer activity.
  • HY-14798
    Palifosfamide
    Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.
  • HY-13669
    Lomustine >98.0%
    Lomustine is a DNA alkylating agent, with antitumor activity.
  • HY-B0181
    Altretamine 99.61%
    Altretamine is an alkylating antineoplastic agent.
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