1. Cell Cycle/DNA Damage
    Apoptosis
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. DNA Alkylator/Crosslinker
    Apoptosis
    Reactive Oxygen Species
    Drug Metabolite
  3. 4-Hydroperoxy cyclophosphamide

4-Hydroperoxy cyclophosphamide 

Cat. No.: HY-117433 Purity: ≥98.0%
Handling Instructions

4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.

For research use only. We do not sell to patients.

4-Hydroperoxy cyclophosphamide Chemical Structure

4-Hydroperoxy cyclophosphamide Chemical Structure

CAS No. : 39800-16-3

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5 mg USD 450 Ask For Quote & Lead Time
10 mg USD 750 Ask For Quote & Lead Time

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Other Forms of 4-Hydroperoxy cyclophosphamide:

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Description

4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.

Molecular Weight

293.08

Formula

C₇H₁₅Cl₂N₂O₄P

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (341.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4120 mL 17.0602 mL 34.1204 mL
5 mM 0.6824 mL 3.4120 mL 6.8241 mL
10 mM 0.3412 mL 1.7060 mL 3.4120 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (8.53 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
4-Hydroperoxy cyclophosphamide
Cat. No.:
HY-117433
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