4-Hydroperoxy Cyclophosphamide-d4
Based on 1 Customer Validation
4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1246816-71-6
- Formula: C7H11D4Cl2N2O4P
- Molecular Weight:297.11
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Storage:
-80°C, stored under nitrogen
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246816-71-6
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Unlabeled Cas 39800-16-3
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Appearance Solid
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Molecular Weight 297.11
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Formula C7H11D4Cl2N2O4P
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Color Off-white to light yellow
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SMILES
N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1
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Shipping
Shipping with dry ice.
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Storage
-80°C, stored under nitrogen
Solvent & Solubility
DMSO : 50 mg/mL (168.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3658 mL | 16.8288 mL | 33.6576 mL | 84.1439 mL |
| 5 mM | 0.6732 mL | 3.3658 mL | 6.7315 mL | 16.8288 mL | |
| 10 mM | 0.3366 mL | 1.6829 mL | 3.3658 mL | 8.4144 mL | |
| 15 mM | 0.2244 mL | 1.1219 mL | 2.2438 mL | 5.6096 mL | |
| 20 mM | 0.1683 mL | 0.8414 mL | 1.6829 mL | 4.2072 mL | |
| 25 mM | 0.1346 mL | 0.6732 mL | 1.3463 mL | 3.3658 mL | |
| 30 mM | 0.1122 mL | 0.5610 mL | 1.1219 mL | 2.8048 mL | |
| 40 mM | 0.0841 mL | 0.4207 mL | 0.8414 mL | 2.1036 mL | |
| 50 mM | 0.0673 mL | 0.3366 mL | 0.6732 mL | 1.6829 mL | |
| 60 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4024 mL | |
| 80 mM | 0.0421 mL | 0.2104 mL | 0.4207 mL | 1.0518 mL | |
| 100 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8414 mL |
4-Hydroperoxy Cyclophosphamide-d4 Related Classifications
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