1. Cell Cycle/DNA Damage Apoptosis NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  2. DNA Alkylator/Crosslinker Apoptosis Reactive Oxygen Species Drug Metabolite
  3. 4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d4 

Cat. No.: HY-117433S Purity: ≥95.0%
COA Handling Instructions

4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

For research use only. We do not sell to patients.

4-Hydroperoxy Cyclophosphamide-d<sub>4</sub> Chemical Structure

4-Hydroperoxy Cyclophosphamide-d4 Chemical Structure

CAS No. : 1246816-71-6

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Based on 1 publication(s) in Google Scholar

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Description

4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.11

Formula

C7H11D4Cl2N2O4P

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1

Shipping

Shipping with dry ice.

Storage

-80°C, stored under nitrogen

Purity & Documentation

Purity: ≥95.0%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
4-Hydroperoxy Cyclophosphamide-d4
Cat. No.:
HY-117433S
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