1. Cell Cycle/DNA Damage
    Apoptosis
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. DNA Alkylator/Crosslinker
    Apoptosis
    Reactive Oxygen Species
    Drug Metabolite
  3. 4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d4 

Cat. No.: HY-117433S
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4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.

For research use only. We do not sell to patients.

4-Hydroperoxy Cyclophosphamide-d4 Chemical Structure

4-Hydroperoxy Cyclophosphamide-d4 Chemical Structure

CAS No. : 1246816-71-6

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Description

4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.11

Formula

C7H11D4Cl2N2O4P

CAS No.
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4-Hydroperoxy Cyclophosphamide-d4
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HY-117433S
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