39800-16-3
39800-16-3
Chemical Structure
4-Hydroperoxy cyclophosphamide
- CAS No.: 39800-16-3
- Formula:C7H15Cl2N2O4P
- Molecular Weight:293.08
IUPAC Name: 2-(bis(2-chloroethyl)amino)-4-hydroperoxy-1,3,2-oxazaphosphinane 2-oxide
InChIKey: VPAWVRUHMJVRHU-UHFFFAOYSA-N
SMILES: O=P1(OCCC(N1)OO)N(CCCl)CCCl
Biological Activity: 4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Hydroperoxy cyclophosphamide | 99.92% | 4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases. | ||||||||||||||||||||
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4-Hydroperoxy cyclophosphamide (Standard) | ≥98% | 4-Hydroperoxy cyclophosphamide (Standard) is the analytical standard of 4-Hydroperoxy cyclophosphamide (HY-117433). This product is intended for research and analytical applications. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases. | ||||||||||||||||||||
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4-Hydroperoxy Cyclophosphamide-d4 | 95.0% | 4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders. | ||||||||||||||||||||
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Trofosfamide | 99.66% | Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity. | ||||||||||||||||||||
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Trofosfamide-d4 | Trofosfamide-d4 is the deuterium labeled Trofosfamide. Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity. | |||||||||||||||||||||
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Acetaldophosphamide | Acetaldophosphamide is a novel stable aldophosphamide analogue. Acetaldophosphamide has potential for cancer research. | |||||||||||||||||||||
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4-Hydroperoxyifosfamide | 98.0% | 4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB). | ||||||||||||||||||||
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Phosphoramide mustard cyclohexanamine | 98.0% | Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage. | ||||||||||||||||||||
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Carboxyphosphamide-d4 | Carboxyphosphamide-d4 is the deuterium labeled Carboxyphosphamide. | |||||||||||||||||||||
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Glufosfamide | 98.0% | Glufosfamide is a glucose-conjugated alkylating cytotoxic agent and a derivative of Ifosfamide (HY-17419). Glufosfamide induces apoptosis frequency and increase the expression of caspase-9 and caspase-3 in cancer cells. Glufosfamide shows great anti-tumor activity in MiaPaCa-2-RFP mouse model. Glufosfamide can be used for the study of hepatocellular carcinoma, prostate cancer and pancreatic carcinoma. | ||||||||||||||||||||
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3,3'-Piperazine-1,4-diyldipropanoic acid | 3,3'-(Piperazine-1,4-diyl)dipropanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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Carboxyphosphamide | 98.15% | Carboxyphosphamide is an inactive metabolite of the alkylating agent Cyclophosphamide (HY-17420). | ||||||||||||||||||||
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Carboxyphosphamide Benzyl Ester-d4 | Carboxyphosphamide Benzyl Ester-d4 is the deuterium labeled Benzyl 3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoate (HY-W701421). | |||||||||||||||||||||
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References
- [1]. Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15(2):332-43. [Content Brief]
- [2]. Niu HQ, et al. Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway. Int Immunopharmacol. 2018 Aug;61:45-53. [Content Brief]
