1. GPCR/G Protein
  2. mGluR

mGluR

mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.

mGluR Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-18941
    LY354740 Agonist >98.0%
    LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, used for treatment of anxiety and stress-related disorders.
  • HY-15445
    CTEP Antagonist
    CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
  • HY-15257
    Mavoglurant Antagonist 99.74%
    Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5.
  • HY-50906
    LY404039 Inhibitor >98.0%
    LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor.
  • HY-70059
    LY341495 Antagonist
    LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.
  • HY-14608A
    L-Glutamic acid monosodium salt Activator >98.0%
    L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
  • HY-107982
    VU6005649 Agonist
    VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
  • HY-110254
    AZD 9272 Inhibitor
    AZD 9272 is a brain penetrant mGluR5 antagonist.
  • HY-N0390
    L-Glutamine Agonist >98.0%
    L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.
  • HY-14609
    MPEP Hydrochloride Antagonist >98.0%
    MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
  • HY-B0122
    Topiramate Antagonist >98.0%
    Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.
  • HY-15446
    RG7090 Inhibitor 98.15%
    RG7090 (Basimglurant, RO4917523) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
  • HY-15748
    JNJ-40411813 Agonist 99.69%
    JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
  • HY-14859
    Dipraglurant Antagonist 99.50%
    Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.
  • HY-18654
    ADX88178 Agonist 98.59%
    ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
  • HY-101845
    FITM Inhibitor 98.82%
    FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.
  • HY-100407
    JNJ16259685 Antagonist 98.02%
    JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
  • HY-100366
    Lu AF21934 Modulator 98.76%
    Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.
  • HY-100371
    (RS)-MCPG Antagonist >98.0%
    (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
  • HY-100406
    (S)-MCPG Antagonist 98.10%
    (S)-MCPG is the active isomer of (RS)-MCPG (Cat. No. HY-100371), non-selective group I/group II metabotropic glutamate receptor antagonist.