2. Others Neuronal Signaling GPCR/G Protein Metabolic Enzyme/Protease Apoptosis
  3. Ferroptosis Environmental Pollutants mGluR Endogenous Metabolite
  4. L-Glutamine

L-Glutamine  (Synonyms: L-Glutamic acid 5-amide)

Cat. No.: HY-N0390 Purity: 98.0%
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L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.

For research use only. We do not sell to patients.

CAS No. : 56-85-9

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Customer Review

Based on 27 publication(s) in Google Scholar

Other Forms of L-Glutamine:

L-Glutamine Related Antibodies

Top Publications Citing Use of Products

    L-Glutamine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 6;16(1):72.  [Abstract]

    The mRNA level of Arg1 in BMDM infected with lentivirus carrying shRNA-NC or shRNA-Blimp-1, and treated with Glutamine (20 mM; 48 h).

    L-Glutamine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 6;16(1):72.  [Abstract]

    The survival rates of CLP mice intraperitoneally injected with macrophage-targeted AAV carrying shRNA-NC or shRNA-Blimp-1, and treated with Glutamine (0.75 g/kg; ip).

    L-Glutamine purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 6;16(1):72.  [Abstract]

    Glutamine (0.75 g/kg; ip). Percentage of M2 macrophages in PLF cells.

    L-Glutamine purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May:71:103112.  [Abstract]

    Cells were infected with PDCoV in media containing different concentrations of Glutamine (0, 1, 2, or 4 mM; 18 h).

    L-Glutamine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2019 Jul 9;28(2):512-525.e6.   [Abstract]

    MTT assay of PC9 cells treated with or without ethylestered GSH (100 μM), or L-Glutamine (10 mM) , together with the indicated doses of GEF for 72 h.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].

    IC50 & Target[4]

    mGluR

     

    Human Endogenous Metabolite

     

    In Vitro

    L-Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, and also provides a source of carbons for oxidation in some cells. L-Glutamine is the most abundant extracellular amino acid in vivo (0.7 mM compared to an approximate L-glutamate concentration of 20 μM)[1].
    In BRIN-BD11 cells, culture for 24 h with 10 mM L-Glutamine compared with 1 mM resulted in substantial changes in gene expression with 148 genes upregulated more than 1.8-fold, and 18 downregulated more than 1.8-fold, including many genes involved in cellular signaling, metabolism, gene regulation, and the insulin-secretory response. L-Glutamine increases the activity of the Ca2+ regulated phosphatase calcineurin and the transcription factor Pdx1[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Glutamine Related Antibodies
    Clinical Trial
    Molecular Weight

    146.15

    Formula

    C5H10N2O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](CCC(N)=O)C(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 33.33 mg/mL (228.05 mM; ultrasonic and adjust pH to 1 with HCl)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.8423 mL 34.2114 mL 68.4229 mL
    5 mM 1.3685 mL 6.8423 mL 13.6846 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 7.69 mg/mL (52.62 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.2%

    SDS (393 KB)

    COA (244 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.8423 mL 34.2114 mL 68.4229 mL 171.0571 mL
    5 mM 1.3685 mL 6.8423 mL 13.6846 mL 34.2114 mL
    10 mM 0.6842 mL 3.4211 mL 6.8423 mL 17.1057 mL
    15 mM 0.4562 mL 2.2808 mL 4.5615 mL 11.4038 mL
    20 mM 0.3421 mL 1.7106 mL 3.4211 mL 8.5529 mL
    25 mM 0.2737 mL 1.3685 mL 2.7369 mL 6.8423 mL
    30 mM 0.2281 mL 1.1404 mL 2.2808 mL 5.7019 mL
    40 mM 0.1711 mL 0.8553 mL 1.7106 mL 4.2764 mL
    50 mM 0.1368 mL 0.6842 mL 1.3685 mL 3.4211 mL
    60 mM 0.1140 mL 0.5702 mL 1.1404 mL 2.8510 mL
    80 mM 0.0855 mL 0.4276 mL 0.8553 mL 2.1382 mL
    100 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7106 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Glutamine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Glutamine56-85-9L-Glutamic acid 5-amideFerroptosisEnvironmental PollutantsmGluREndogenous MetaboliteEnvironmental ContaminantsMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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