L-Glutamine-15N-1
Based on 4 publication(s) in Google Scholar
L-Glutamine-15N-1 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
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- Pureté: 98.0%
- CAS No.: 59681-32-2
- Formule: C5H10N15NO3
- Masse moléculaire:147.14
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Glutamine-15N-1
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 59681-32-2
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Unlabeled Cas 56-85-9
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Appearance Solid
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Masse moléculaire 147.14
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Formule C5H10N15NO3
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Color White to off-white
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SMILES
[15NH2]C(CC[C@H](N)C(O)=O)=O
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Synonyms
L-Glutamic acid 5-amide-15N-1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Oncogene
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation. [Abstract]2025 May;44(16):1078-1092. PMID: 39865175 -
Cell Rep
mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase. [Abstract]2025 Jan 13;44(1):115179. PMID: 39808525 -
Cell Rep
IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth. [Abstract]2024 Dec 30;44(1):115116. PMID: 39739531 -
Solvant et solubilité
H2O : 25 mg/mL (169.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (84.95 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Zhou T, et al. Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis. Stem Cells Int. 2019;2019:8928934. Published 2019 Sep 12. [Content Brief]
[3]. Luo LL, et al. L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70. CNS Neurosci Ther. 2019;25(9):1030-1041. [Content Brief]
[4]. Shao H, et al. The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. BMC Pharmacol Toxicol. 2020;21(1):71. Published 2020 Oct 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7962 mL | 33.9812 mL | 67.9625 mL | 169.9062 mL |
| 5 mM | 1.3592 mL | 6.7962 mL | 13.5925 mL | 33.9812 mL | |
| 10 mM | 0.6796 mL | 3.3981 mL | 6.7962 mL | 16.9906 mL | |
| 15 mM | 0.4531 mL | 2.2654 mL | 4.5308 mL | 11.3271 mL | |
| 20 mM | 0.3398 mL | 1.6991 mL | 3.3981 mL | 8.4953 mL | |
| 25 mM | 0.2718 mL | 1.3592 mL | 2.7185 mL | 6.7962 mL | |
| 30 mM | 0.2265 mL | 1.1327 mL | 2.2654 mL | 5.6635 mL | |
| 40 mM | 0.1699 mL | 0.8495 mL | 1.6991 mL | 4.2477 mL | |
| 50 mM | 0.1359 mL | 0.6796 mL | 1.3592 mL | 3.3981 mL | |
| 60 mM | 0.1133 mL | 0.5664 mL | 1.1327 mL | 2.8318 mL | |
| 80 mM | 0.0850 mL | 0.4248 mL | 0.8495 mL | 2.1238 mL | |
| 100 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6991 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Glutamine-15N-1 Related Classifications
HY-N0390S9 Related Classifications
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