mGluR1

mGluR1 Related Products (30):

By Type:	Pan (9) Selective (15)
By Effects:	Inhibitors (3) Agonists (9) Antagonists (13) Activator (1) Modulators (4)

Cat. No.	Product Name	Effect	Purity

HY-70059

LY341495	Antagonist	99.50%
LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC₅₀s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively.

HY-100403

Ro 67-7476	Agonist	99.57%
Ro 67-7476 is a potent positive allosteric modulator of mGluR₁ and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC₅₀ of 60.1 nM.

HY-12598A

DHPG	Agonist	99.65%
DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs.

HY-107515A

LY367385 hydrochloride	Antagonist	98.05%
LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist.

HY-100407

JNJ16259685	Antagonist	98.10%
JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC₅₀ of 19 nM.

HY-100786

DL-AP3	Antagonist	≥98.0%
DL-AP3 is a competitive mGluR1 and mGluR5 antagonist.

HY-15129

O-Phospho-L-serine	Modulator	≥98.0%
O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.

HY-12598

(S)-3,5-DHPG	Agonist	≥99.0%
(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with K_i values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively.

HY-124419

RO0711401	Agonist	99.64%
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC₅₀ of 56 nM.

HY-100382

FPTQ	Antagonist	99.88%
FPTQ is potent mGluR₁ antagonist with IC₅₀ values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.

HY-100402

CFMTI	Antagonist	≥98.0%
CFMTI inhibits L-glutamate-induced intracellular Ca²⁺ mobilization in CHO cells expressing human and rat mGluR1a, with IC₅₀s of 2.6 and 2.3 nM, respectively.

HY-12597

Quisqualic acid	Activator	≥98.0%
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R.

HY-W017230

L-Cysteinesulfinic acid monohydrate	Agonist	99.30%
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

HY-11095

NPS 2390	Antagonist	98.83%
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5.

HY-101845

FITM	Inhibitor	98.19%
FITM is a negative allosteric modulator of mGlu1 receptor with a K_i of 2.5 nM.

HY-100405

FTIDC	Inhibitor
FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC₅₀ of 5.8 nM for human mGluR1a.

HY-100804

L-Cysteinesulfinic acid	Agonist	99.31%
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

HY-136587

Oxomemazine	Antagonist	99.18%
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties.

HY-107515

LY367385	Antagonist	≥99.0%
LY367385 is a highly selective and potent mGluR1a antagonist.

HY-103568

YM-298198 hydrochloride	Antagonist	≥99.0%
YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1).

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