1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR1 Inhibitors

mGluR1 Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

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Sorry. There is currently no product that acts on isoform mGluR1 together.

Please try each isoform separately.

mGluR1 Specific Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR1 mGluR8 mGluR6 mGluR7 mGluR5 mGluR4 mGluR3 mGluR2 mGluR1 Selectivity Purity
JNJ16259685
mGluR1, IC50: 19 nM
              Selective Antagonist 98.85%
FITM
mGlu1, Ki: 2.5 nM
              Selective Inhibitor 98.19%
Ro 67-7476
mGluR1a, EC50: 60.1 nM
              Selective Agonist 99.80%
FPTQ
Human mGluR1, IC50: 6 nM
Mouse mGluR1, IC50: 1.4 nM
              Selective Antagonist 99.91%
CFMTI
Human mGluR1a, IC50: 2.6 nM
Rat mGluR1a, IC50: 2.3 nM
              Selective Antagonist >98.0%
Oxomemazine
mGluR 1, Ki: 84 nM
           
mGluR2, Ki: 1.65 μM
Selective Antagonist
LY367385
mGluR1a, IC50: 8.8 μM
              Selective Antagonist >99.0%
DFMTI
mGluR1
              Selective Inhibitor 99.32%
LY341495
mGluR1a, IC50: 7.8 μM
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR5a, IC50: 8.2 μM
mGluR4, IC50: 22 μM
mGluR3, IC50: 14 nM
mGluR2, IC50: 21 nM
Pan Antagonist 99.11%
DHPG
mGluR 1
     
mGluR 5
      Pan Agonist >97.0%
L-Cysteinesulfinic acid monohydrate
mGluR1, pEC50: 3.92
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
Pan Agonist
O-Phospho-L-serine
mGluR1
mGluR8
mGluR6
mGluR7
 
mGluR4
 
mGluR2
Pan Modulator >98.0%
L-Cysteinesulfinic acid
mGluR1, pEC50: 3.92
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
Pan Agonist
Quisqualic acid
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
       
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
 
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
Pan Activator
(S)-3,5-DHPG
mGluR1a, Ki: 0.9 μM
     
mGluR5a, Ki: 3.9 μM
      Pan Agonist
DCG-IV
mGluR1R, IC50: 389 μM
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR5, IC50: 630 μM
mGluR4R, IC50: 22.5 μM
mGluR3R, EC50: 0.09 μM
mGluR2R, EC50: 0.35 μM
Pan Agonist
VU-29
rat mGluR1, EC50: 557 nM
     
rat mGluR5, EC50: 9 nM
rat mGluR5, Ki: 224 nM
hmGluR4, EC50: 154 nM
 
rat mGluR2, EC50: 1.5 μM
Pan Agonist
YM-298198 hydrochloride
mGluR 1
              default Antagonist