1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR1 Inhibitors

mGluR1 Inhibitors

mGluR8

mGluR6

mGluR7

mGluR5

mGluR4

mGluR3

mGluR2

mGluR1

mGluR

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform mGluR1 together.

Please try each isoform separately.

mGluR1 Specific Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name mGluR1 mGluR8 mGluR6 mGluR7 mGluR5 mGluR4 mGluR3 mGluR2 mGluR1 Selectivity Purity
JNJ16259685
mGluR1, IC50: 19 nM
              Selective Antagonist 98.85%
FITM
mGlu1, Ki: 2.5 nM
              Selective Inhibitor 98.19%
Ro 67-7476
mGluR1a, EC50: 60.1 nM
              Selective Agonist 99.80%
FPTQ
Human mGluR1, IC50: 6 nM
Mouse mGluR1, IC50: 1.4 nM
              Selective Antagonist 99.91%
CFMTI
Human mGluR1a, IC50: 2.6 nM
Rat mGluR1a, IC50: 2.3 nM
              Selective Antagonist >98.0%
LY367385
mGluR1a, IC50: 8.8 μM
              Selective Antagonist >99.0%
FTIDC
mGluR1a, IC50: 5.8 nM
     
mGlu5, IC50: 6200 nM
      Selective Inhibitor
DFMTI
mGluR1
              Selective Inhibitor 99.32%
LY341495
mGluR1a, IC50: 7.8 μM
mGluR8, IC50: 170 nM
 
mGluR7, IC50: 990 nM
mGluR5a, IC50: 8.2 μM
mGluR4, IC50: 22 μM
mGluR3, IC50: 14 nM
mGluR2, IC50: 21 nM
Pan Antagonist 99.11%
DHPG
mGluR 1
     
mGluR 5
      Pan Agonist >97.0%
L-Cysteinesulfinic acid monohydrate
mGluR1, pEC50: 3.92
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
Pan Agonist
O-Phospho-L-serine
mGluR1
mGluR8
mGluR6
mGluR7
 
mGluR4
 
mGluR2
Pan Modulator >98.0%
LY404039
mGluR1, Ki: 149 nM
           
mGluR2, Ki: 92 nM
Pan Inhibitor >98.0%
L-Cysteinesulfinic acid
mGluR1, pEC50: 3.92
mGluR8, pEC50: 3.94
mGluR6, pEC50: 4.0
 
mGluR5, pEC50: 4.6
mGluR4, pEC50: 2.7
 
mGluR2, pEC50: 3.9
Pan Agonist
Quisqualic acid
mGluR1R, EC50: 45 nM
mGluR1R, Ki: 10 nM
       
mGluR4R, IC50: 593 μM
mGluR4R, Ki: 112 μM
 
mGluR2R, IC50: 108 μM
mGluR2R, Ki: 113 μM
Pan Activator
(S)-3,5-DHPG
mGluR1a, Ki: 0.9 μM
     
mGluR5a, Ki: 3.9 μM
      Pan Agonist
DCG-IV
mGluR1R, IC50: 389 μM
mGluR8, IC50: 32 μM
mGluR6, IC50: 39.6 μM
mGluR7, IC50: 40.1 μM
mGluR5, IC50: 630 μM
mGluR4R, IC50: 22.5 μM
mGluR3R, EC50: 0.09 μM
mGluR2R, EC50: 0.35 μM
Pan Agonist