1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. mGluR
  4. mGluR1 Isoform

mGluR1

 

mGluR1 Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-70059
    LY341495
    Antagonist 99.50%
    LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively.
  • HY-100403
    Ro 67-7476
    Agonist 99.57%
    Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM.
  • HY-12598A
    DHPG
    Agonist 99.65%
    DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs.
  • HY-107515A
    LY367385 hydrochloride
    Antagonist 98.05%
    LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist.
  • HY-100407
    JNJ16259685
    Antagonist 98.10%
    JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
  • HY-100786
    DL-AP3
    Antagonist ≥98.0%
    DL-AP3 is a competitive mGluR1 and mGluR5 antagonist.
  • HY-15129
    O-Phospho-L-serine
    Modulator ≥98.0%
    O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
  • HY-12598
    (S)-3,5-DHPG
    Agonist ≥99.0%
    (S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively.
  • HY-124419
    RO0711401
    Agonist 99.64%
    RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.
  • HY-100382
    FPTQ
    Antagonist 99.88%
    FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively.
  • HY-100402
    CFMTI
    Antagonist ≥98.0%
    CFMTI inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively.
  • HY-12597
    Quisqualic acid
    Activator ≥98.0%
    Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R.
  • HY-W017230
    L-Cysteinesulfinic acid monohydrate
    Agonist 99.30%
    L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
  • HY-11095
    NPS 2390
    Antagonist 98.83%
    NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5.
  • HY-101845
    FITM
    Inhibitor 98.19%
    FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.
  • HY-100405
    FTIDC
    Inhibitor
    FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a.
  • HY-100804
    L-Cysteinesulfinic acid
    Agonist 99.31%
    L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
  • HY-136587
    Oxomemazine
    Antagonist 99.18%
    Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties.
  • HY-107515
    LY367385
    Antagonist ≥99.0%
    LY367385 is a highly selective and potent mGluR1a antagonist.
  • HY-103568
    YM-298198 hydrochloride
    Antagonist ≥99.0%
    YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1).